The DOI matches its Crossref record; 208 of the 220 references it cites were found in a registry or an index.
Organic anion transporter (Slc22a) family members as mediators of toxicity
Abstract
Exposure of the body to toxic organic anions is unavoidable and occurs from both intentional and unintentional sources. Many hormones, neurotransmitters, and waste products of cellular metabolism, or their metabolites, are organic anions. The same is true for a wide variety of medications, herbicides, pesticides, plant and animal toxins, and industrial chemicals and solvents. Rapid and efficient elimination of these substances is often the body's best defense for limiting both systemic exposure and the duration of their pharmacological or toxicological effects. For organic anions, active transepithelial transport across the renal proximal tubule followed by elimination via the urine is a major pathway in this detoxification process. Accordingly, a large number of organic anion transport proteins belonging to several different gene families have been identified and found to be expressed in the proximal nephron. The function of these transporters, in combination with the high volume of renal blood flow, predisposes the kidney to increased toxic susceptibility. Understanding how the kidney mediates the transport of organic anions is integral to achieving desired therapeutic outcomes in response to drug interactions and chemical exposures, to understanding the progression of some disease states, and to predicting the influence of genetic variation upon these processes. This review will focus on the organic anion transporter (OAT) family and discuss the known members, their mechanisms of action, subcellular localization, and current evidence implicating their function as a determinant of the toxicity of certain endogenous and xenobiotic agents.
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“These gene counts represent significant expansions of the SLC22 family, which consists of only 5 genes in humans and mice”
From The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome (2006) · cites this paper as Sweet, 2005
In the citing paper
“Both SLC22 and ABC efflux proteins (see above) export metals directly or as glutathione (GSH) conjugates (Leslie et al., 2001;Sweet, 2005), and the urchin genome contains multiple genes in the subfamilies known to be involved in resistance to heavy metal toxicity.”
From The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome (2006) · cites this paper as Sweet, 2005
Citations
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Cited by
Sorted by citations
Sarkadi, B., Homolya, L., Szakács, G., & Váradi, A. (2006) · Physiological Reviews · doi:10.1152/physrev.00037.2005 · Cited by 726
Szakács, G., Váradi, A., Özvegy‐Laczka, C., & Sarkadi, B. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2007.12.010 · Cited by 565
Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
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“However, we note in particular that selective tissue-concentrating mechanisms may also be a cause of toxicit”
BackgroundRamaiahgari, S., den Braver, M. W., Herpers, B., Terpstra, V., Commandeur, J. N. M., van de Water, B., & Price, L. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1215-9 · Cited by 373
“The expression levels of OAT2 and OAT7, which represent major transporters of various clinically relevant drug classes (Kobayashi et al. 2005; sweet 2005), were highly increased in spheroids compared to 2D culture.”
BackgroundCaraco, Y., Blotnick, S., & Muszkat, M. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100316 · Cited by 359
Metadata
- Authors
- Sweet, D. H.
- Affiliations
- Medical University of South Carolina (US)
- Corresponding author
- Sweet, Douglas H.
- ORCID
- Sweet, Douglas H.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 204
- Issue
- 3
- Pages
- 198-215
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2124824529
- Cited by
- 150
- References
- 220
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 8 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 9 · 2013: 6 · 2012: 12
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology and Applied Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- organic anion transporters, proximal tubule, drug toxicity, xenobiotic transport, drug interactions, subcellular localization
- MeSH terms
- Animals, Pharmaceutical Preparations, Humans, Kidney, Toxins, Biological, Organic Anion Transporters, Drug-Related Side Effects and Adverse Reactions
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