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Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework
Open accessAbstract
Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
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Metadata
- Authors
- Calabrese, E. J., Bachmann, K. A., Bailer, A. J., Bolger, P. M., Borak, J., Cai, L., Cedergreen, N., Cherian, M. G., Chiueh, C. C., Clarkson, T. W., Cook, R. R., Diamond, D. M., Doolittle, D. J., Dorato, M. A., Duke, S. O., Feinendegen, L., Gardner, D. E., Hart, R. W., Hastings, K. L., Hayes, A. W., Hoffmann, G. R., Ives, J. A., Jaworowski, Z., Johnson, T. E., Jonas, W. B., Kaminski, N. E., Keller, J. G., Klaunig, J. E., Knudsen, T. B., Kozumbo, W. J., Lettieri, T., Liu, S.-Z., Maisseu, A., Maynard, K. I., Masoro, E. J., McClellan, R. O., Mehendale, H. M., Mothersill, C., Newlin, D. B., Nigg, H. N., Oehme, F. W., Phalen, R. F., Philbert, M. A., Rattan, S. I. S., Riviere, J. E., Rodricks, J., Sapolsky, R. M., Scott, B. R., Seymour, C., Sinclair, D. A., Smith-Sonneborn, J., Snow, E. T., Spear, L., Stevenson, D. E., Thomas, Y., Tubiana, M., Williams, G. M., & Mattson, M. P.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 222
- Issue
- 1
- Pages
- 122-128
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2083899916
- Cited by
- 750
- References
- 0
- FWCI
- 26.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Calabrese, E. J., Bachmann, K. A., Bailer, A. J., Bolger, P. M., Borak, J., Cai, L., Cedergreen, N., Cherian, M. G., Chiueh, C. C., Clarkson, T. W., Cook, R. R., Diamond, D. M., Doolittle, D. J., Dorato, M. A., Duke, S. O., Feinendegen, L., Gardner, D. E., Hart, R. W., Hastings, K. L., . . . Mattson, M. P. (2007). Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework. Toxicology and Applied Pharmacology. https://doi.org/10.1016/j.taap.2007.02.015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
