Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease

Pathobiology of ischaemic stroke: an integrated view

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A Neurotrophic Model for Stress-Related Mood Disorders

Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works

Pathways towards and Away from Alzheimer’s Disease

Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works

Trk Receptors: Roles in Neuronal Signal Transduction

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Major depressive disorder

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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

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From charcot to lou gehrig: deciphering selective motor neuron death in als

Cleveland, D. W., & Rothstein, J. D. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097565 · Cited by 1,389 · see citing works

Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B. R., Goffredo, D., Conti, L., MacDonald, M. E., Friedlander, R. M., Silani, V., Hayden, M. R., et al. (2001) · Science · doi:10.1126/science.1059581 · Cited by 1,319 · see citing works

Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus

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Ageing and neuronal vulnerability

Mattson, M. P., & Magnus, T. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1886 · Cited by 1,075 · see citing works

The cell biology of synaptic plasticity: AMPA receptor trafficking

Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978 · see citing works

Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice

Lee, J., Duan, W., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01085.x · Cited by 975 · see citing works

BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

Mattson, M. P., Maudsley, S., & Martin, B. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.001 · Cited by 942 · see citing works

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

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BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

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Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non‐NMDA glutamate receptors.

Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H., & Lindholm, D. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07564.x · Cited by 897 · see citing works

Edema and brain trauma

Unterberg, A. W., Stover, J., Kress, B., & Kiening, K. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.046 · Cited by 881 · see citing works

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

Mattson, M. P., Cheng, B., Culwell, A. R., Esch, F. S., Lieberburg, I. M., & Rydel, R. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90315-i · Cited by 795 · see citing works

Interaction between BDNF and Serotonin: Role in Mood Disorders

Martinowich, K., & Lu, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301571 · Cited by 793 · see citing works

Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment

Warner‐Schmidt, J. L., & Duman, R. S. (2006) · Hippocampus · doi:10.1002/hipo.20156 · Cited by 787 · see citing works

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework

Calabrese, E. J., Bachmann, K. A., Bailer, A. J., Bolger, P. M., Borak, J. B., Cai, L., Nina Cedergreen, G., Cherian, M. G., Chiueh, C. C., Clarkson, T. W., et al. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.02.015 · Cited by 751 · see citing works

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

Young, D., Lawlor, P. A., Leone, P., Dragunow, M., & During, M. J. (1999) · Nature Medicine · doi:10.1038/7449 · Cited by 731 · see citing works

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

Cheng, B., Christakos, S., & Mattson, M. P. (1994) · Neuron · doi:10.1016/0896-6273(94)90159-7 · Cited by 669 · see citing works

Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment

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Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca 2+ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

Mattson, M. P., Lovell, M. A., Furukawa, K., & Markesbery, W. R. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041740.x · Cited by 615 · see citing works

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons

Stranahan, A. M., Arumugam, T. V., Cutler, R. G., Lee, K. M., Egan, J. M., & Mattson, M. P. (2008) · Nature Neuroscience · doi:10.1038/nn2055 · Cited by 610 · see citing works

Roles for NF-κB in nerve cell survival, plasticity, and disease

Mattson, M. P., & Meffert, M. K. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401837 · Cited by 597 · see citing works

Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons.

Zafra, F., Ċastrén, E., Thoenen, H., & Lindholm, D. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10037 · Cited by 580 · see citing works

Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons

Mattson, M. P., Dou, P., & Kater, S. B. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-02087.1988 · Cited by 557 · see citing works

Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs

Patterson, S. L., Grover, L. M., Schwartzkroin, P. A., & Bothwell, M. (1992) · Neuron · doi:10.1016/0896-6273(92)90067-n · Cited by 555 · see citing works

Reduced BDNF mRNA Expression in the Parkinson's Disease Substantia Nigra

Howells, D. W., Porritt, M. J., Wong, J. Y. F., Batchelor, P. E., Kalnins, R., Hughes, A. J., & Donnan, G. A. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7483 · Cited by 513 · see citing works

E PIDEMIOLOGY OF N EURODEGENERATION

Mayeux, R. P. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.043002.094919 · Cited by 511 · see citing works

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

Guo, Q., Fu, W., Sopher, B. L., Miller, M. W., Ware, C. B., Martin, G. M., & Mattson, M. P. (1999) · Nature Medicine · doi:10.1038/4789 · Cited by 489 · see citing works

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

Mattson, M. P., Murrain, M., Guthrie, P., & Kater, S. B. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-11-03728.1989 · Cited by 484 · see citing works

Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders

Mattson, M. P. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:2:65 · Cited by 475 · see citing works

Overview on the structure, composition, function, development, and plasticity of hippocampal dendritic spines

Sorra, K. E., & Harris, K. M. (2000) · Hippocampus · doi:10.1002/1098-1063(2000)10:5 · Cited by 456 · see citing works

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

Lee, J., Seroogy, K. B., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00747.x · Cited by 455 · see citing works

A controlled trial of recombinant methionyl human BDNF in ALS

The BDNF Study Group (Phase III) (1999) · Neurology · doi:10.1212/wnl.52.7.1427 · Cited by 453 · see citing works

Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor

Li, Y., Jia, Y., Cui, K., Li, N., Zheng, Z.-Y., Wang, Y., & Yuan, X. (2005) · Nature · doi:10.1038/nature03477 · Cited by 451 · see citing works

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

Duan, W., Guo, Z., Jiang, H., Ware, M., Li, X.-J., & Mattson, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536856100 · Cited by 428 · see citing works

Traumatic Brain Injury‐Induced Excitotoxicity Assessed in a Controlled Cortical Impact Model

Palmer, A. M., Marion, D. W., Botscheller, M. L., Swedlow, P. E., Styren, S. D., & DeKosky, S. T. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb07437.x · Cited by 412 · see citing works

Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium

Knable, M. B., Barci, B. M., Webster, M. J., Meador‐Woodruff, J. H., & Torrey, Ε. F. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001471 · Cited by 407 · see citing works

A double‐blind placebo‐controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis

ALS CNTF Treatment Study Group (1996) · Neurology · doi:10.1212/wnl.46.5.1244 · Cited by 405 · see citing works

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

Cheng, B., & Mattson, M. P. (1994) · Brain Research · doi:10.1016/0006-8993(94)91857-0 · Cited by 395 · see citing works

Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease

Mogi, M., Togari, A., Kondo, T., Mizuno, Y., Komure, O., Kuno, S., Ichinose, H., & Nagatsu, T. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00463-2 · Cited by 394 · see citing works

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

Maswood, N., Young, J. M., Tilmont, E. M., Zhang, Z.-M., Gash, D., Gerhardt, G., Grondin, R., Roth, G., Mattison, J., Lane, M., et al. (2004) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0405831102 · Cited by 371 · see citing works

Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism

Spires‐Jones, T. L., Grote, H., Varshney, N. K., Cordery, P. M., van Dellen, A., Blakemore, C. B., & Hannan, A. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1658-03.2004 · Cited by 367 · see citing works

Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus

Oliff, H. S., Berchtold, N. C., Isackson, P., & Cotman, C. W. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00222-8 · Cited by 361 · see citing works

Brain-Derived Neurotrophic Factor Regulates the Onset and Severity of Motor Dysfunction Associated with Enkephalinergic Neuronal Degeneration in Huntington's Disease

Canals, J. M., Pineda, J. R., Torres-Peraza, J. F., Bosch, M., Martín‐Ibáñez, R., Muñoz, M. T., Mengod, G., Ernfors, P., & Alberch, J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1197-04.2004 · Cited by 345 · see citing works

Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases

Mattson, M. P., Pedersen, W. A., Duan, W., Culmsee, C., & Camandola, S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07824.x · Cited by 343 · see citing works

Evidence for Synaptic Apoptosis

Mattson, M. P., Keller, J. N., & Begley, J. G. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6863 · Cited by 340 · see citing works

Brain-derived neurotrophic factor in Huntington disease

Ferrer, I., Goutan, E., Marı́n, C., Rey, M. J., & Ribalta, T. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02237-x · Cited by 333 · see citing works

Long-term depression: multiple forms and implications for brain function

Massey, P. V., & Bashir, Z. I. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.02.005 · Cited by 325 · see citing works

Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation

Behrens, P. F. (2002) · Brain · doi:10.1093/brain/awf180 · Cited by 322 · see citing works

Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain

Cheng, A., Wang, S., Cai, J., Rao, M. S., & Mattson, M. P. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00120-9 · Cited by 310 · see citing works

Endogenous Neuroprotection Factors and Traumatic Brain Injury: Mechanisms of Action and Implications for Therapy

Mattson, M. P., & Scheff, S. W. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.3 · Cited by 308 · see citing works

Molecular Mechanism of Neuronal Plasticity: Induction and Maintenance of Long-Term Potentiation in the Hippocampus

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Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95

Sun, Y., Savanenin, A., Reddy, P. H., & Liu, Y. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103501200 · Cited by 297 · see citing works

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons.

Mattson, M. (1990) · Neuron · doi:10.1016/0896-6273(90)90447-n · Cited by 292 · see citing works

Beyond Monoamines: Glutamatergic Function in Mood Disorders

Kugaya, A., & Sanacora, G. (2005) · CNS Spectrums · doi:10.1017/s1092852900010403 · Cited by 291 · see citing works

Localized striatal delivery of GDNF as a treatment for Parkinson disease

Kirik, D., Georgievska, B., & Björklund, A. (2004) · Nature Neuroscience · doi:10.1038/nn1175 · Cited by 289 · see citing works

Role of BDNF in bipolar and unipolar disorder: Clinical and theoretical implications

Post, R. M. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.09.009 · Cited by 286 · see citing works

Brain-Derived Neurotrophic Factor Enhances Long-Term Potentiation in Rat Visual Cortex

Akaneya, Y., Tsumoto, T., Kinoshita, S., & Hatanaka, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06707.1997 · Cited by 284 · see citing works

Excitotoxicity and nitric oxide in parkinson's disease pathogenesis

Beal, M. F. (1998) · Annals of Neurology · doi:10.1002/ana.410440716 · Cited by 283 · see citing works

Effect of Brain-Derived Neurotrophic Factor Treatment and Forced Arm Use on Functional Motor Recovery After Small Cortical Ischemia

Schäbitz, W.-R., Berger, C., Kollmar, R., Seitz, M., Tanay, E., Kiessling, M., Schwab, S., & Sommer, C. (2004) · Stroke · doi:10.1161/01.str.0000119754.85848.0d · Cited by 283 · see citing works

Increased Expression of TGF-β1 in Brain Tissue After Ischemic Stroke in Humans

Krupiński, J., Kumar, P., Kumar, S., & Kałuza, J. (1996) · Stroke · doi:10.1161/01.str.27.5.852 · Cited by 282 · see citing works

Adult Hippocampal Neurogenesis, Synaptic Plasticity and Memory: Facts and Hypotheses

Bruel‐Jungerman, E., Rampon, C., & Laroche, S. (2007) · Reviews in the Neurosciences · doi:10.1515/revneuro.2007.18.2.93 · Cited by 281 · see citing works

Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson’s disease

Levivier, M., Przedborski, S., Bencsics, C., & Kang, U. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07810.1995 · Cited by 274 · see citing works

The Actin-Severing Protein Gelsolin Modulates Calcium Channel and NMDA Receptor Activities and Vulnerability to Excitotoxicity in Hippocampal Neurons

Furukawa, K., Fu, W., Li, Y., Witke, W., Kwiatkowski, D. J., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08178.1997 · Cited by 269 · see citing works

ALS-Linked Cu/Zn–SOD Mutation Increases Vulnerability of Motor Neurons to Excitotoxicity by a Mechanism Involving Increased Oxidative Stress and Perturbed Calcium Homeostasis

Kruman, I. I., Pedersen, W. A., Springer, J. E., & Mattson, M. P. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7190 · Cited by 268 · see citing works

A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin

Mattson, M. P., Maudsley, S. R., & Martin, B. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.08.001 · Cited by 266 · see citing works

Antidepressant and anxiolytic‐like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

Cryan, J. F., Kelly, P. H., Neijt, H. C., Sansig, G., Flor, P. J., & van der Putten, H. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02667.x · Cited by 266 · see citing works

Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose

Mattson, M. P., Zhang, Y., & Bose, S. C. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1066 · Cited by 265 · see citing works

Nuclear Ca2+ and the cAMP Response Element-Binding Protein Family Mediate a Late Phase of Activity-Dependent Neuroprotection

Papadia, S., Stevenson, P., Hardingham, N. R., Bading, H., & Hardingham, G. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5019-04.2005 · Cited by 262 · see citing works

The Molecular Basis of Memantine Action in Alzheimers Disease and Other Neurologic Disorders: Low-affinity, Uncompetitive Antagonism

Lipton, S. A. (2005) · Current Alzheimer Research · doi:10.2174/1567205053585846 · Cited by 256 · see citing works

IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage

Cheng, B., & Mattson, M. P. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-04-01558.1992 · Cited by 254 · see citing works

Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies.

Hazell, A. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.026 · Cited by 254 · see citing works

NMDA and AMPA receptors: old channels, new tricks

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Calcium as sculptor and destroyer of neural circuitry

Mattson, M. P. (1992) · Experimental Gerontology · doi:10.1016/0531-5565(92)90027-w · Cited by 250 · see citing works

Insulin-Like Growth Factor-I Is a Differentiation Factor for Postmitotic CNS Stem Cell-Derived Neuronal Precursors: Distinct Actions from Those of Brain-Derived Neurotrophic Factor

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Long-term potentiation: outstanding questions and attempted synthesis

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The role of cytokines and growth factors in seizures and their sequelae

Jankowsky, J. L., & Patterson, P. H. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00022-8 · Cited by 239 · see citing works

A role for AMPA receptors in mood disorders

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Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs

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Expression Profiling of Huntington's Disease Models Suggests That Brain-Derived Neurotrophic Factor Depletion Plays a Major Role in Striatal Degeneration

Strand, A. D., Baquet, Z. C., Aragaki, A. K., Holmans, P., Yang, L., Cléren, C., Beal, M. F., Jones, L., Kooperberg, C. L., Olson, J. M., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2461-07.2007 · Cited by 210 · see citing works

The NMDA Receptor as a Therapeutic Target in Major Depressive Disorder

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Activity-dependent Release of Brain-derived Neurotrophic Factor Underlies the Neuroprotective Effect of N-Methyl-d-aspartate

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Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

Mattson, M. P., Kumar, K. N., Wang, H., Cheng, B., & Michaelis, E. K. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-11-04575.1993 · Cited by 195 · see citing works

Reversal of Behavioral and Metabolic Abnormalities, and Insulin Resistance Syndrome, by Dietary Restriction in Mice Deficient in Brain-Derived Neurotrophic Factor

Duan, W., Guo, Z., Jiang, H., Ware, M., & Mattson, M. P. (2003) · Endocrinology · doi:10.1210/en.2002-0113 · Cited by 194 · see citing works

NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection

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Neurotrophin-Dependent Modulation of Glutamatergic Synaptic Transmission in the Mammalian CNS

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Endogenous α-Synuclein Is Induced by Valproic Acid through Histone Deacetylase Inhibition and Participates in Neuroprotection against Glutamate-Induced Excitotoxicity

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Brain‐derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

Duan, W., Guo, Z., & Mattson, M. P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00071.x · Cited by 187 · see citing works

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