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Cited by 321

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression

Pinton, Philippe, Nougayrède, Jean-Philippe, Del Rio, Juan-Carlos, Moreno, Carolina, Marin, Daniela E., Ferrier, Laurent, Bracarense, Ana-Paula, Kolf-Clauw, Martine, Oswald, Isabelle P.·2009·Toxicology and Applied Pharmacology
DOI 10.1016/j.taap.2009.03.003
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Abstract

'The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects. Through consumption of contaminated cereals and cereal products, human and pigs are exposed to this mycotoxin. Using in vitro, ex vivo and in vivo approaches, we investigated the effects of DON on the intestinal epithelium. We demonstrated that, in intestinal epithelial cell lines from porcine (IPEC-1) or human (Caco-2) origin, DON decreases trans-epithelial electrical resistance (TEER) and increases in a time and dose-dependent manner the paracellular permeability to 4 kDa dextran and to pathogenic Escherichia coli across intestinal cell monolayers. In pig explants treated with DON, we also observed an increased permeability of intestinal tissue. These alterations of barrier function were associated with a specific reduction in the expression of claudins, which was also seen in vivo in the jejunum of piglets exposed to DON-contaminated feed. In conclusion, DON alters claudin expression and decreases the barrier function of the intestinal epithelium. Considering that high levels of DON may be present in food or feed, consumption of DON-contaminated food/feed may induce intestinal damage and has consequences for human and animal health.

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Metadata

Authors
Pinton, P., Nougayrède, J.-P., Del Rio, J.-C., Moreno, C., Marin, D. E., Ferrier, L., Bracarense, A.-P., Kolf-Clauw, M., & Oswald, I. P.
Venue
Toxicology and Applied Pharmacology
Publisher
Elsevier BV
Published
2009-05
Volume
237
Issue
1
Pages
41-48
ISSN
0041-008X (ISSN-L)
DOI
10.1016/j.taap.2009.03.003
OpenAlex
W1987265868
Cited by
321
References
37
FWCI
18.14
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression. https://app.cochat.ai/papers/10.1016/j.taap.2009.03.003
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Pinton, P., Nougayrède, J.-P., Del Rio, J.-C., Moreno, C., Marin, D. E., Ferrier, L., Bracarense, A.-P., Kolf-Clauw, M., & Oswald, I. P. (2009). The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression. Toxicology and Applied Pharmacology. https://doi.org/10.1016/j.taap.2009.03.003

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.