Bisphenol-A rapidly enhanced passive avoidance memory and phosphorylation of NMDA receptor subunits in hippocampus of young rats
Abstract
Bisphenol-A (BPA), an endocrine disruptor, is found to influence development of brain and behaviors in rodents. The previous study indicated that perinatal exposure to BPA impaired learning-memory and inhibited N-methyl-D-aspartate receptor (NMDAR) subunits expressions in hippocampus during the postnatal development in rats; and in cultured hippocampal neurons, BPA rapidly promotes dynamic changes in dendritic morphology through estrogen receptor-mediated pathway by concomitant phosphorylation of NMDAR subunit NR2B. In the present study, we examined the rapid effect of BPA on passive avoidance memory and NMDAR in the developing hippocampus of Sprague-Dawley rats at the age of postnatal day 18. The results showed that BPA or estradiol benzoate (EB) rapidly extended the latency to step down from the platform 1 h after footshock and increased the phosphorylation levels of NR1, NR2B, and mitogen-activated extracellular signal-regulated kinase (ERK) in hippocampus within 1 h. While 24 h after BPA or EB treatment, the improved memory and the increased phosphorylation levels of NR1, NR2B, ERK disappeared. Furthermore, pre-treatment with an estrogen receptors (ERs) antagonist, ICI182,780, or an ERK-activating kinase inhibitor, U0126, significantly attenuated EB- or BPA-induced phosphorylations of NR1, NR2B, and ERK within 1 h. These data suggest that BPA rapidly enhanced short-term passive avoidance memory in the developing rats. A non-genomic effect via ERs may mediate the modulatio…
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ERK signaling is involved in the chronic effect of BPA on dendritic morphogenesis in hippocampal neurons.
“Our previous studies have demonstrated that ERK signaling is involved not only in the chronic effect of BPA on dendritic morphogenesis in hippocampal neurons but also in the rapid effect of BPA on passive avoidance memory of young rats [12, 23].”
From The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation (2017) · cites this paper as [23]
ERK signaling is involved in the rapid effect of BPA on passive avoidance memory of young rats.
“Our previous studies have demonstrated that ERK signaling is involved not only in the chronic effect of BPA on dendritic morphogenesis in hippocampal neurons but also in the rapid effect of BPA on passive avoidance memory of young rats [12, 23].”
From The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation (2017) · cites this paper as [23]
Cites
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Xu, X.-H., Zhang, J., Wang, Y.-M., Ye, Y.-P., & Luo, Q.-Q. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.02.012 · Cited by 211 · see citing works
Self-citationRapid Estrogen Signaling in the Brain
Raz, L., Khan, M. M., Mahesh, V. B., Vadlamudi, R. K., & Brann, D. W. (2008) · Neurosignals · doi:10.1159/000111559 · Cited by 201 · see citing works
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High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations
Jang, Y. J., Park, H. R., Kim, T. H., Yang, W.-J., Lee, J.-J., Choi, S. Y., Oh, S. B., Lee, E., Park, J.-H., Kim, H.-P., et al. (2012) · Toxicology · doi:10.1016/j.tox.2012.03.007 · Cited by 82 · see citing works
Chen, X., Wang, Y., Xu, F., Wei, X., Zhang, J., Wang, C., Wei, H., Xu, S., Yan, P., Zhou, W., et al. (2017) · Neural Plasticity · doi:10.1155/2017/5196958 · Cited by 24 · see citing works
“Our previous studies have demonstrated that ERK signaling is involved not only in the chronic effect of BPA on dendritic morphogenesis in hippocampal neurons but also in the rapid effect of BPA on passive avoidance memory of young rats [12, 23].”
BackgroundSelf-citation
- Authors
- Xu, X., Li, T., Luo, Q., Hong, X., Xie, L., & Tian, D.
- Affiliations
- Zhejiang Normal University (CN)
- Corresponding author
- Xu, Xiaohong
- ORCID
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 255
- Issue
- 2
- Pages
- 221-228
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2116144731
- Cited by
- 49
- References
- 3
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 7 · 2012: 5
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology and Applied Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30771783, 30872087)
- Zhejiang Province Natural Science Foundation (Z2090955)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- bisphenol A, endocrine disruptors, passive avoidance memory, NMDA receptor subunits, ERK signaling, hippocampus, postnatal development, estradiol benzoate, estrogen receptor, non-genomic estrogen signaling, fulvestrant, U0126
- MeSH terms
- Fulvestrant, Bisphenol A Compounds, Animals, Avoidance Learning, Behavior, Animal, Benzhydryl Compounds, Butadienes, Enzyme Inhibitors, Estradiol, Estrogen Antagonists, Hippocampus, Male, Memory, Nitriles, Phenols, Phosphorylation, Blotting, Western, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Extracellular Signal-Regulated MAP Kinases, Rats, Endocrine Disruptors
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