The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Intermediate filaments take the heat as stress proteins
Open accessAbstract
Intermediate filament (IF) proteins and heat shock proteins (HSPs) are large multi-membered families that share several features. These features include protein abundance, significant up-regulation in response to a variety of stresses, function as cytoprotectors, and the phenocopying of several human diseases upon IF protein or HSP mutation. We are now coming to understand that these common elements point to IFs as important cellular stress proteins with some roles akin to those already well-characterized for HSPs. Unique functional roles for IFs include protection from mechanical stress while HSPs are characteristically involved in protein folding and as chaperones. Shared IF and HSP cytoprotective roles include inhibition of apoptosis, organelle homeostasis, and scaffolding. We review here recent data that corroborate the view that IFs function as highly-specialized cytoskeletal stress proteins that promote cellular organization and homeostasis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Podocyte-Selective Deletion of Dicer Induces Proteinuria and Glomerulosclerosis
Shi, S., Yu, L., Chiu, C., Sun, Y., Chen, J., Khitrov, G., Merkenschlager, M., Holzman, L. B., Zhang, W., Mundel, P., et al. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008030312 · Cited by 349
Caron, M., Auclair, M., Donadille, B., Béréziat, V, Guerci, B., Laville, M., Narbonne, H., Bodemer, C., Lascols, O., Capeau, J., et al. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402197 · Cited by 226 · cited 1×
“Furthermore, lipodystrophy-causing lamin A mutations result in the accumulation of farnesylated prelamin A and oxidative stress that trigger premature cellular senescence [97], and it has been shown that lamin levels in cell culture are related to the presence of serum [98].”
BackgroundNishio, K., Inoue, A., Qiao, S., Kondo, H., & Mimura, A. (2001) · Histochemistry and Cell Biology · doi:10.1007/s004180100325 · Cited by 115
Cited by
Ultrastructural Characterization of Zika Virus Replication Factories
Cortese, M., Goellner, S., Acosta, E. G., Neufeldt, C. J., Oleksiuk, O., Lampe, M., Haselmann, U., Funaya, C., Schieber, N., Ronchi, P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.014 · Cited by 359
Gilbert, H. T. J., Mallikarjun, V., Dobre, O., Jackson, M. R., Pedley, R., Gilmore, A. P., Richardson, S. M., & Swift, J. (2019) · Nature Communications · doi:10.1038/s41467-019-11923-1 · Cited by 91
Tracing the evolutionary origin of desmosomes
Green, K. J., Roth-Carter, Q., Niessen, C. M., & Nichols, S. A. (2020) · Current Biology · doi:10.1016/j.cub.2020.03.047 · Cited by 56
Metadata
- Authors
- Toivola, D. M., Strnad, P., Habtezion, A., & Omary, M. B.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 20
- Issue
- 2
- Pages
- 79-91
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W1971095161
- Cited by
- 280
- References
- 3
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Intermediate filaments take the heat as stress proteins. https://app.cochat.ai/papers/10.1016/j.tcb.2009.11.004
- The paper
- Toivola, D. M., Strnad, P., Habtezion, A., & Omary, M. B. (2010). Intermediate filaments take the heat as stress proteins. Trends in Cell Biology. https://doi.org/10.1016/j.tcb.2009.11.004
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
