The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Proteolytic networks in cancer
Open accessAbstract
Proteases are important for multiple processes during malignant progression including tumor angiogenesis, invasion and metastasis. Recent evidence reveals that tumor-promoting proteases function as part of an extensive multidirectional network of proteolytic interactions, in contrast to the unidirectional caspase cascade. These networks involve different constituents of the tumor microenvironment, and key proteases — such as cathepsin B, urokinase-type plasminogen activator and several matrix metalloproteinases — occupy central nodes for amplifying proteolytic signals passing through the network. The proteolytic network interacts with other important signaling pathways in tumor biology, involving chemokines, cytokines, and kinases. Viewing these proteolytic interactions as a system of activating and inhibiting reactions provides insight into tumor biology and reveals relevant pharmaceutical targets. This review will examine recent advances in understanding proteases in cancer, and summarize how their network of activity is co-opted to promote tumor progression.
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Cites
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Microenvironmental regulation of metastasis
Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684
Self-citationMMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis
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S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death
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Chemokine-protease interactions in cancer
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Cited by
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940
Tumour acidosis: from the passenger to the driver's seat
Corbet, C., & Feron, O. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.77 · Cited by 988
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response
Olson, O. C., & Joyce, J. A. (2015) · Nature Reviews Cancer · doi:10.1038/nrc4027 · Cited by 699
Self-citationWhat are the respiratory effects of e-cigarettes?
Gotts, J. E., Jordt, S.-E., McConnell, R., & Tarran, R. (2019) · BMJ · doi:10.1136/bmj.l5275 · Cited by 516
Metadata
- Authors
- Mason, S. D., & Joyce, J. A.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 21
- Issue
- 4
- Pages
- 228-237
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W1997104566
- Cited by
- 552
- References
- 7
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
