Redox regulation of cell migration and adhesion
Open accessAbstract
Reactive oxygen species (ROS), particularly hydrogen peroxide, and the proteins that regulate them play important roles in the migration and adhesion of cells. Stimulation of cell surface receptors with growth factors and chemoattractants generates ROS, which relay signals from the cell surface to key signaling proteins inside the cell. ROS act within cells to promote migration and also in nonmigrating cells to influence the behavior of migrating cells. Hydrogen peroxide has also been suggested to act as a chemoattractant in its own right, drawing immune cells to wounds. We discuss recent progress made towards understanding how organisms use ROS, and to what degree they depend on them, during the related processes of cell migration and adhesion.
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The established model holds that H2O2 generated at the leading edge oxidizes scaffold proteins and promotes cell migration.
“The phenomenon is consistent with the established model that H2O2 generated at the leading edge oxidizes scaffold proteins and promotes cell migration. [39]”
From Multiplex Cellular Microenvironment Detection Based on Surface-Enhanced Raman Scattering Patch (2025) · cites this paper as [39]
In “ROS act within cells to promote their migration,” the paper describes a model in which hydrogen peroxide generated at the leading edge oxidizes proteins and promotes migration. It identifies protein tyrosine phosphatases as possible oxidation targets; scaffold proteins instead help localize and activate the oxidase. The claim incorrectly names scaffold proteins as the targets. (LLM, conf=0.90)
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References 102 · Cited by 263
Research works printed but not linked: 2
- [16]Sundaresan M Requirement for generation of H2O2 for platelet-derived growth factor signal transduction Science 1995 270 296 299 7569979
- [31]Rhee SG Controlled elimination of intracellular H2O2: regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification Antioxid. Redox Signal 2005 7 619 626 15890005
- Authors
- Hurd, T. R., DeGennaro, M., & Lehmann, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Hurd, Thomas Ryan
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 22
- Issue
- 2
- Pages
- 107-115
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC4515034
- OpenAlex
- W2012713600
- Cited by
- 263
- References
- 102
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 25 · 2023: 16 · 2022: 20 · 2021: 15 · 2020: 20 · 2019: 19 · 2018: 12 · 2017: 22 · 2016: 18 · 2015: 16 · 2014: 24 · 2013: 15 · 2012: 5
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Canadian Institutes of Health Research
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD041900, R37HD041900)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- reactive oxygen species, hydrogen peroxide, cell migration, cell adhesion, redox signaling, chemoattractants, growth factor signaling, immune cell recruitment, wound healing
- MeSH terms
- Animals, Cell Adhesion, Cell Movement, Humans, Hydrogen Peroxide, Oxidation-Reduction
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