The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.
Evading apoptosis in cancer
Open accessAbstract
Carcinogenesis is a mechanistically complex and variable process with a plethora of underlying genetic causes. Cancer development consists of a multitude of steps that occur progressively starting with initial driver mutation(s), to tumorigenesis, and ultimately metastasis. During these transitions, cancer cells accumulate a series of genetic alterations that confer upon the cells an unwarranted survival and proliferative advantage. During the course of development, however, cancer cells also encounter a physiologically ubiquitous cellular program that aims to eliminate damaged or abnormal cells: Apoptosis. Thus, it is essential that cancer cells acquire instruments to circumvent programmed cell death. Here we discuss emerging evidence indicating how cancer cells adopt various strategies to override apoptosis including amplifying the anti-apoptotic machinery, downregulating the pro-apoptotic program, or both.
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2 retracted
Akt Phosphorylation and Stabilization of X-linked Inhibitor of Apoptosis Protein (XIAP)
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Mechanisms of drug resistance in colon cancer and its therapeutic strategies
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Metadata
- Authors
- Fernald, K., & Kurokawa, M.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 23
- Issue
- 12
- Pages
- 620-633
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2006483529
- Cited by
- 579
- References
- 196
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- green
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