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Oncomirs—MicroRNAs with a role in cancer

Esquela-Kerscher, Aurora, Slack, Frank J.·2006·Nature Reviews Cancer
DOI 10.1038/nrc1840
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Abstract

MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.

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Metadata

Authors
Esquela-Kerscher, A., & Slack, F. J.
Venue
Nature Reviews Cancer
Publisher
Springer Science and Business Media LLC
Published
2006-04
Volume
6
Issue
4
Pages
259-269
ISSN
  • 1474-175X
  • 1474-1768
DOI
10.1038/nrc1840
Cited by
5,884
References
10
Language
en
Licence
www.springer.com/tdm (tdm)

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