The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
The Elusive P2X7 Macropore
Open accessAbstract
ATP, which is released under pathological conditions and is considered a damage-associated molecular pattern (DAMP), activates P2X7 receptors (P2X7Rs), trimeric plasma membrane ion channels selective for small cations. P2X7Rs are partners in NOD-like receptor containing a pyrin (NLRP3) inflammasome activation and promoters of tumor cell growth. P2X7R overstimulation triggers the ATP-dependent opening of a nonselective plasma membrane pore, known as a 'macropore', which allows fluxes of large hydrophilic molecules. The pathophysiological functions of P2X7R are thought to be dependent on activation of this conductance pathway, yet its molecular identity is unknown. Recent reports show that P2X7R permeability to organic solutes is an early and intrinsic property of the channel itself. A better understanding of P2X7R-dependent changes in plasma membrane permeability will allow a rationale development of novel anti-inflammatory and anticancer drugs.
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“The P2X7 receptor is a trimeric ionotropic receptor that belongs to the P2X family of purinergic receptors, presenting low affinity for ATP (EC50 around 0.3–1.8 mM) and, under prolonged stimulation, can form pores allowing the passage of large hydrophilic molecules [62–64].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [64]
Citations
Cites
Molecular Physiology of P2X Receptors
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The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )
Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
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The P2X7 Receptor in Infection and Inflammation
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Altered Cytokine Production in Mice Lacking P2X7Receptors
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Pathophysiology and Therapeutic Potential of Purinergic Signaling
Burnstock, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.5 · Cited by 618
Nanobodies and nanobody-based human heavy chain antibodies as antitumor therapeutics
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Ischemia Opens Neuronal Gap Junction Hemichannels
Thompson, R. J., Zhou, N., & MacVicar, B. A. (2006) · Science · doi:10.1126/science.1126241 · Cited by 560
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Extracellular ATP and P2 purinergic signalling in the tumour microenvironment
Virgilio, F. D., Sarti, A. C., Falzoni, S., Marchi, E. D., & Adinolfi, E. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0037-0 · Cited by 748
Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
Muzio, L., Viotti, A., & Martino, G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.742065 · Cited by 581
Zhou, Y., Fei, M., Zhang, G., Liang, W., Lin, W., Wu, Y., Piskol, R., Ridgway, J. B., McNamara, E., Huang, H., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.01.014 · Cited by 406
Biological responses to physicochemical properties of biomaterial surface
Rahmati, M., Silva, E. A., Reseland, J. E., Heyward, C. A., & Haugen, H. J. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00103a · Cited by 409
Update of P2X receptor properties and their pharmacology: IUPHAR Review 30
Illés, P., Müller, C. E., Jacobson, K. A., Grütter, T., Nicke, A., Fountain, S. J., Kennedy, C., Schmalzing, G., Jarvis, M. F., Stojilković, S. S., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15299 · Cited by 327
Self-citation
Metadata
- Authors
- Di Virgilio, F., Schmalzing, G., & Markwardt, F.
- Affiliations
- RWTH Aachen University (DE)
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 28
- Issue
- 5
- Pages
- 392-404
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2787249947
- Cited by
- 279
- References
- 96
- Citations by year
- 2026: 23 · 2025: 22 · 2024: 41 · 2023: 44 · 2022: 31 · 2021: 30 · 2020: 33 · 2019: 37 · 2018: 17
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by-nc-nd)
- Funders
- Italian Association for Cancer Research (13025, 18581)
- Ministry of Health of Italy (RF-2011-02348435)
- University of Ferrara
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- P2X7 receptor, ATP, plasma membrane permeability, NLRP3 inflammasome, damage-associated molecular patterns, ion channel conductance, anti-inflammatory agents, anticancer agents
- MeSH terms
- Alarmins, NLR Family, Pyrin Domain-Containing 3 Protein, Adenosine Triphosphate, Cell Membrane Permeability, Humans, Neoplasms, Signal Transduction, Cell Proliferation, Receptors, Purinergic P2X7, Inflammasomes
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