The P2X7 receptor: A main player in inflammation

Adinolfi, Elena; Giuliani, Anna Lisa; De Marchi, Elena; Pegoraro, Anna; Orioli, Elisa; Di Virgilio, Francesco

doi:10.1016/j.bcp.2017.12.021

Cited by 385Adenosine and Purinergic SignalingImmune Response and InflammationInflammasome and immune disorders

The P2X7 receptor: A main player in inflammation

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Adinolfi, Elena, Giuliani, Anna Lisa, De Marchi, Elena, Pegoraro, Anna, Orioli, Elisa, Di Virgilio, Francesco·2018·Biochemical Pharmacology

DOI 10.1016/j.bcp.2017.12.021

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Abstract

Damage associated molecular patterns (DAMPs) are intracellular molecules released from infected or injured cells to activate inflammatory and reparatory responses. One of the most ancient and conserved DAMPs is extracellular ATP that exerts its phlogistic activity mainly through activation of the P2X7 receptor (P2X7R). The P2X7R is an ATP gated ion channel, expressed by most immune cells, including the monocyte-derived cell lineages, T and B lymphocytes and their precursors. Here we give an overview of recent and established literature on the role of P2X7R in septic and sterile inflammation. P2X7R ability in restraining intracellular bacteria and parasite infection by modulation of the immune response are described, with particular focus on Mycobacteria and Plasmodium. Emerging literature on the role of P2X7 in viral infections such as HIV-1 is also briefly covered. Finally, we describe the numerous intracellular pathways related to inflammation and activated by the P2X7R, including the NLRP3 inflammasome, NF-kB, NFAT, GSK3β and VEGF, and discuss the involvement of P2X7R in chronic diseases. The possible therapeutic applications of P2X7R antagonists are also described.

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Activation of P2X7 receptors induced by viral infection leads to molecular alterations (neuroimmune response activation, ROS formation, and glutamate release), behavioral alterations, and mental disorders.
“their activation induced by viral infection leads to molecular (mainly neuroimmune response activation, reactive oxygen species (ROS) formation, and glutamate release) and behavioral alterations [17, 20] as well as to mental disorders [21].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [20]
Consequently, there is an activation of caspase-1 and maturation of IL-1β and IL-18, resulting in pro-inflammatory cytokine release.
“Consequently, there is an activation of caspase-1 and maturation of IL-1β and IL-18, resulting in pro-inflammatory cytokine release [16, 20, 52, 71, 73].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [20]
The P2X7 receptor participates in viral infections, exerting mostly pro-inflammatory roles, is important for pathogen elimination, but its activation may be detrimental to the host due to induction of exacerbated inflammatory responses.
“The P2X7 receptor, as a central player in inflammation, participates in viral infections. Exerting mostly pro-inflammatory roles [20], the P2X7 receptor is important for pathogen elimination [108], but on the other hand, its activation may be detrimental to the host due to the induction of exacerbated inflammatory responses.”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [20]

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P2X7 receptor‐stimulation causes fever via PGE2 and IL‐1β release
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Effects of P2Y12 receptor antagonists beyond platelet inhibition – comparison of ticagrelor with thienopyridines
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Extracellular ATP May Contribute to Tissue Repair by Rapidly Stimulating Purinergic Receptor X7-Dependent Vascular Endothelial Growth Factor Release from Primary Human Monocytes
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A phase I clinical trial demonstrates that nfP2X7 -targeted antibodies provide a novel, safe and tolerable topical therapy for basal cell carcinoma
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Pyroptosis: Caspase-11 Unlocks the Gates of Death
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Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages
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Discovery and structure–activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor
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Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death
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Emerging Roles of P2X Receptors in Cancer
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Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7
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Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome
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Purinergic Receptor Functionality Is Necessary for Infection of Human Hepatocytes by Hepatitis Delta Virus and Hepatitis B Virus
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Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation
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Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P 2 X 7 receptors
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Exogenous ATP enhances calcium influx in intact thymocytes.
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Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice
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The purinergic receptor P2X7 role in control of Dengue virus-2 infection and cytokine/chemokine production in infected human monocytes
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Involvement of the P2X7 Purinergic Receptor and c-Jun N-Terminal and Extracellular Signal-Regulated Kinases in Cyclooxygenase-2 and Prostaglandin E2 Induction by LL-37
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Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor
Swanson, D. M., Savall, B. M., Coe, K. J., Schoetens, F., Koudriakova, T. B., Skaptason, J., Wall, J. L., Rech, J. C., Deng, X., Angelis, M. D., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00989 · Cited by 38 · see citing works
Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?
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Self-citation
Cathelicidin LL‐37 induces time‐resolved release of LTB 4 and TXA 2 by human macrophages and triggers eicosanoid generation in vivo
Wan, M., Soehnlein, O., Tang, X. Y., van der Does, A. M., Smedler, E., Uhlén, P., Lindbom, L., Agerberth, B., & Haeggström, J. Z. (2014) · The FASEB Journal · doi:10.1096/fj.14-251306 · Cited by 37 · see citing works
The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control
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Novel P2X7 receptor antagonists ease the pain
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Purinergic Signaling Induces Cyclooxygenase-1-Dependent Prostanoid Synthesis in Microglia: Roles in the Outcome of Excitotoxic Brain Injury
Anrather, J., Gallo, E. F., Kawano, T., Orio, M., Abe, T., Gooden, C., Zhou, P., & Iadecola, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025916 · Cited by 36 · see citing works
Tenidap enhances P2Z/P2X7 receptor signalling in macrophages
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P2 receptor networks regulate signaling duration over a wide dynamic range of ATP concentrations
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Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation
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Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human
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Monocytes P2X7 purinergic receptor is modulated by glatiramer acetate in multiple sclerosis
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The Beneficial Effects of P2X7 Antagonism in Rats with Bile Duct Ligation-induced Cirrhosis
Tung, H., Lee, F., Wang, S.-S., Tsai, M.-H., Lee, J.-Y., Huo, T., Huang, H., Chuang, C., Lin, H., & Lee, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124654 · Cited by 32 · see citing works
Fluorimetric assay of the neurotensin-degrading metalloendopeptidase, endopeptidase 24.16
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P2X7 Receptor Inhibition Improves CD34 T-Cell Differentiation in HIV-Infected Immunological Nonresponders on c-ART
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P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages
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Purinergic signaling is required for fluid shear stress-induced NF-κB translocation in osteoblasts
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Purinergic P2X Receptors: Structural and Functional Features Depicted by X-Ray and Molecular Modelling Studies
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Activation of the Inositol Phospholipid Signaling System by Receptors for Extracellular ATP in Human Neutrophils, Monocytes, and Neutrophil/Monocyte Progenitor Cells
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Cobalt Protoporphyrin Upregulates Cyclooxygenase-2 Expression Through a Heme Oxygenase-Independent Mechanism
Lin, H., Tsai, C., Lin, C., Yeh, W., Tsai, C., Chang, P.-C., Wu, L.-H., & Lu, D. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9376-y · Cited by 19 · see citing works
Purinergic signaling in giant cell formation
Lemaire, I. B. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e359 · Cited by 18 · see citing works
Purinergic signaling in giant cell formation
Lemaire, I. B. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/359 · Cited by 15 · see citing works

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Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy
Vezzani, A., Balosso, S., & Ravizza, T. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0217-x · Cited by 907 · see citing works
Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
Hemonnot, A.-L., Hua, J., Ulmann, L., & Hirbec, H. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00233 · Cited by 298 · see citing works
Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity
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Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer’s disease
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Extracellular nucleotides and nucleosides as signalling molecules
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The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment
Marchi, E. D., Orioli, E., Pegoraro, A., Sangaletti, S., Portararo, P., Curti, A., Colombo, M. P., Virgilio, F. D., & Adinolfi, E. (2019) · Oncogene · doi:10.1038/s41388-019-0684-y · Cited by 197 · see citing works
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Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy
Kong, H., Zhao, H., Chen, T., Song, Y., & Cui, Y. T. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04786-w · Cited by 185 · see citing works
P2X7 in Cancer: From Molecular Mechanisms to Therapeutics
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The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies
Zhao, N., Di, B., & Xu, L. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.06.002 · Cited by 156 · see citing works
Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression
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Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works
P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes
Wang, D., Wang, H., Gao, H., Zhang, H., Zhang, H., Wang, Q., & Sun, Z. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00388-1 · Cited by 145 · see citing works
Inflammatory signaling mechanisms in bipolar disorder
Jones, G. H., Vecera, C. M., Pinjari, O. F., & Machado‐Vieira, R. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00742-6 · Cited by 141 · see citing works
The Interplay between Intracellular Iron Homeostasis and Neuroinflammation in Neurodegenerative Diseases
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Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell
Yao, M., Fan, X., Yuan, B., Takagi, N., Liu, S., Han, X., Ren, J., & Liu, J. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2615-4 · Cited by 121 · see citing works
Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study
Cattaneo, A., Ferrari, C., Turner, L., Mariani, N., Enache, D., Hastings, C. N. M., Kose, M., Lombardo, G., McLaughlin, A. P., Nettis, M. A., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00874-7 · Cited by 115 · see citing works
A central role for P2X7 receptors in human microglia
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Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders
Bhattacharya, A., & Jones, D. N. C. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.08.015 · Cited by 105 · see citing works
The Nlrp3 inflammasome as a “rising star” in studies of normal and malignant hematopoiesis
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ATP and adenosine—Two players in the control of seizures and epilepsy development
Beamer, E. H., Kuchukulla, M., Boison, D., & Engel, T. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102105 · Cited by 99 · see citing works
Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway
Chai, Y., Cai, Y., Fu, Y., Wang, Y., Zhang, Y., Zhang, X., Zhu, L., Miao, M., & Yan, T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.812362 · Cited by 100 · see citing works
The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases
Calzaferri, F., Ruiz‐Ruiz, C., de Diego, A. M. G., de Pascual, R., Méndez‐López, I., Cano‐Abad, M. F., Maneu, V., Rı́os, C. D. L., Gandı́a, L., & de Diego, A. M. G. (2020) · Medicinal Research Reviews · doi:10.1002/med.21710 · Cited by 98 · see citing works
P2X7 Receptor: A Potential Therapeutic Target for Depression?
Deussing, J. M., & Arzt, E. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.07.005 · Cited by 97 · see citing works
The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis
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Gene expression studies in Depression development and treatment: an overview of the underlying molecular mechanisms and biological processes to identify biomarkers
Mariani, N., Cattane, N., Pariante, C. M., & Cattaneo, A. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01469-6 · Cited by 91 · see citing works
Molecular Mechanisms Related to Oxidative Stress in Retinitis Pigmentosa
Gallenga, C. E., Lonardi, M., Pacetti, S., Violanti, S. S., Tassinari, P., Virgilio, F. D., Tognon, M. G., & Perri, P. (2021) · Antioxidants · doi:10.3390/antiox10060848 · Cited by 79 · see citing works
AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia
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Regulation of P2X7 receptor expression and function in the brain
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Ectonucleotidases in Acute and Chronic Inflammation
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Control of Metastases via Myeloid CD39 and NK Cell Effector Function
Yan, J., Li, X.-Y., Aguilera, A. R., Xiao, C., Jacoberger-Foissac, C., Nowlan, B., Robson, S. C., Beers, C., Moesta, A. K., Geetha, N., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0749 · Cited by 74 · see citing works
Targeting Inflammasomes to Treat Neurological Diseases
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Role of purines in regulation of metabolic reprogramming
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P2X7 Receptors in Neurodegeneration: Potential Therapeutic Applications From Basic to Clinical Approaches
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Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure
Campagno, K. E., Lu, W., Jassim, A. H., Albalawi, F., Cenaj, A., Tso, H., Clark, S. P., Sripinun, P., Gómez, N. M., & Mitchell, C. H. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02251-7 · Cited by 67 · see citing works
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation
Sun, W., Wang, Q., Zhang, R., & Zhang, N. (2023) · Food & Function · doi:10.1039/d3fo00122a · Cited by 67 · see citing works
Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation
Irazoqui, J. E. (2020) · Trends in Immunology · doi:10.1016/j.it.2019.12.003 · Cited by 63 · see citing works
P2X7 Variants in Oncogenesis
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Structural and Functional Basis for Understanding the Biological Significance of P2X7 Receptor
Martínez-Cuesta, M. Á., Blanch‐Ruiz, M. A., Ortega‐Luna, R., Sánchez‐López, A., & Álvarez, Á. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228454 · Cited by 62 · see citing works
Structural basis for the functional properties of the P2X7 receptor for extracellular ATP
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P2X4 and P2X7 are essential players in basal T cell activity and Ca 2+ signaling milliseconds after T cell activation
Brock, V. J., Wolf, I. M. A., Er-Lukowiak, M., Lory, N. C., Stähler, T., Woelk, L.-M., Mittrücker, H., Müller, C. E., Koch‐Nolte, F., Rissiek, B., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl9770 · Cited by 59 · see citing works
Trikafta Rescues CFTR and Lowers Monocyte P2X7R-induced Inflammasome Activation in Cystic Fibrosis
Gabillard-Lefort, C., Casey, M., Glasgow, A. M. A., Boland, F., Kerr, O., Marron, E., Lyons, A. M., Gunaratnam, C., McElvaney, N. G., & Reeves, E. P. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202106-1426oc · Cited by 57 · see citing works
Role of the P2X7 receptor in tumor-associated inflammation
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The role of NLRP3 inflammasome in inflammation-related skeletal muscle atrophy
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P2X7 receptors drive poly(I:C) induced autism-like behavior in mice
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P2X7 receptor signaling promotes inflammation in renal parenchymal cells suffering from ischemia-reperfusion injury
Qian, Y., Qian, C., Xie, K., Fan, Q., Yan, Y., Lu, R., Wang, L., Zhang, M., Wang, Q., Mou, S., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03384-y · Cited by 56 · see citing works
PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment
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Purine and purinergic receptors in health and disease
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P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases
Mishra, A., Behura, A., Kumar, A., Naik, L., Swain, A., Das, M., Sarangi, S. S., Dokania, P., Dirisala, V. R., Bhutia, S. K., et al. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174235 · Cited by 53 · see citing works
Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer
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Inhibition of P2X7 Purinergic Receptor Ameliorates Fibromyalgia Syndrome by Suppressing NLRP3 Pathway
D’Amico, R., Fusco, R., Siracusa, R., Impellizzeri, D., Peritore, A. F., Gugliandolo, E., Interdonato, L., Sforza, A. M., Crupi, R., Cuzzocrea, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126471 · Cited by 51 · see citing works
Inflamed brain: Targeting immune changes and inflammation for treatment of depression
Sakamoto, S., Zhu, X., Hasegawa, Y., Karma, S., Obayashi, M., Alway, E., & Kamiya, A. (2021) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13286 · Cited by 51 · see citing works
P2X7 receptor in inflammation and pain
Hu, S.-Q., Hu, J., Zou, F.-L., Liu, J., Luo, H., Hu, D.-X., Wu, L., & Zhang, W. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.07.006 · Cited by 50 · see citing works
ATP and adenosine: Role in the immunopathogenesis of rheumatoid arthritis
da Silva, J. L. G., Passos, D. F., Bernardes, V. M., & Leal, D. B. R. (2019) · Immunology Letters · doi:10.1016/j.imlet.2019.08.009 · Cited by 51 · see citing works
Radiotherapy and Cytokine Storm: Risk and Mechanism
Zhang, C., Liang, Z., Ma, S., & Liu, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.670464 · Cited by 50 · see citing works
Gallic Acid Alleviates Visceral Pain and Depression via Inhibition of P2X7 Receptor
Wen, L., Tang, L., Zhang, M., Wang, C., Li, S., Wen, Y., Tu, H., Tian, H., Wei, J., Liang, P., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116159 · Cited by 50 · see citing works
Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis
Zhou, X., Jin, S., Pan, J., Lin, Q., Yang, S., Ambe, P. C., Basharat, Z., Zimmer, V., Wang, W., & Hong, W. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.927193 · Cited by 50 · see citing works
Inhibition of P2X7 Purinergic Receptor Ameliorates Cardiac Fibrosis by Suppressing NLRP3/IL-1β Pathway
Zhou, J., Tian, G., Quan, Y., Li, J., Wang, X., Wu, W., Li, M., & Liu, X. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7956274 · Cited by 50 · see citing works
P2X7R promotes angiogenesis and tumour‐associated macrophage recruitment by regulating the NF‐κB signalling pathway in colorectal cancer cells
Yang, C., Shi, S., Su, Y., Tong, J., & Li, L. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15708 · Cited by 50 · see citing works
Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway
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Authors: Adinolfi, E., Giuliani, A. L., De Marchi, E., Pegoraro, A., Orioli, E., & Di Virgilio, F.
Affiliations: University of Ferrara (IT)
ORCID: Adinolfi, Elena
Giuliani, Anna Lisa
Pegoraro, Anna
Orioli, Elisa
Venue: Biochemical Pharmacology
Publisher: Elsevier BV
Published: 2018-05
Volume: 151
Pages: 234-244
ISSN: 0006-2952 (ISSN-L)
DOI: 10.1016/j.bcp.2017.12.021
OpenAlex: W2779261291
Cited by: 385
References: 181
Citations by year: 2026: 35 · 2025: 40 · 2024: 43 · 2023: 54 · 2022: 61 · 2021: 60 · 2020: 46 · 2019: 26 · 2018: 20
FWCI: 2.65
Type: journal article
Language: en
Open access: green
www.sciencedirect.com
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical Pharmacology (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by-nc-nd)
Funders: Italian Association for Cancer Research (IG 13025, IG 18581)
Ministry of Health of Italy (RF-2011-02348435)
University of Ferrara
AIRC (IG 16812)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: P2X7 receptor, extracellular ATP, damage-associated molecular patterns, sepsis, sterile inflammation, Mycobacterium, Plasmodium, HIV-1, NLRP3 inflammasome, NF-kB, NFAT, GSK3β, vascular endothelial growth factor, chronic disease, P2X7 receptor antagonists, innate immunity
MeSH terms: Animals, Autoimmune Diseases, Chronic Disease, Clinical Trials as Topic, Communicable Diseases, Drug Evaluation, Preclinical, Humans, Inflammation, Neoplasms, Neurodegenerative Diseases, Receptors, Purinergic P2X7, Inflammasomes, Purinergic P2X Receptor Agonists, Purinergic P2X Receptor Antagonists

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The P2X7 receptor: A main player in inflammation

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