CoChat
Sign Up
Cited by 67Acute Myocardial Infarction ResearchCannabis and Cannabinoid ResearchCardiac Health and Mental Health

The DOI matches its Crossref record.

Marijuana use and acute myocardial infarction: A systematic review of published cases in the literature

Patel, Rikinkumar S., Kamil, Saher H., Bachu, Ramya, Adikey, Archana, Ravat, Virendrasinh, Kaur, Mandeep, Tankersley, William E., Goyal, Hemant·2020·Trends in Cardiovascular Medicine
DOI 10.1016/j.tcm.2019.08.003
Open this paper in CoChat — free account

Abstract

Background and objective Marijuana use has gained popularity following legalization in the US. Marijuana can affect the heart through various mechanisms. This study aims to conduct a systematic review of published case reports of individuals with acute myocardial infarction (AMI) following marijuana use. Methods We conducted a systematic review of literature, including case reports, case series, and the letter to the editor on MEDLINE. Forty-six studies were included, with a total number of 62 patients with AMI and marijuana use. Results The mean age was 27.7 (±10.3) years with male predominance. About 3.7 g marijuana was used for an average of 9.7 years by the patients. From the cases reporting the onset of AMI symptoms, the average time was within 5 h after last marijuana use. The angiographic findings were normal in 36.8% of cases. In 42.1% of individuals, the left anterior descending coronary artery was occluded, making it the most common artery involved, followed by the right coronary artery (10.5%). Most cases were managed medically, followed by thrombectomy and stent placement, and percutaneous transluminal coronary angioplasty (PTCA). Complications included cardio-embolic stroke, and seven deaths were reported. Conclusion It is important to consider episodic marijuana use as a significant risk factor of AMI, particularly in individuals with no cardiac risk factors, as delay in management can result in fatal outcomes including increased risk of mortality.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.tcm.2019.08.003

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 72

  1. Jouanjus, 2018, Cardiovascular complications of cannabis use, Trends Cardiovasc Med
  2. Goyal, 2017, Role of cannabis in cardiovascular disorders, J Thorac Dis, 9, 2079, 10.21037/jtd.2017.06.104 · DOI
  3. Patel, 2018, Cannabis use disorder in young adults with acute myocardial infarction: trend inpatient study from 2010 to 2014 in the united states, Cureus, 10, e3241
  4. Mittleman, 2001, Triggering myocardial infarction by marijuana, Circulation, 103, 2805, 10.1161/01.CIR.103.23.2805 · DOI
  5. Aronow, 1974, Effect of marihuana and placebo-marihuana smoking on angina pectoris, N Engl J Med, 291, 65, 10.1056/NEJM197407112910203 · DOI
  6. Mukamal, 2008, An exploratory prospective study of marijuana use and mortality following acute myocardial infarction, Am Heart J, 155, 465, 10.1016/j.ahj.2007.10.049 · DOI
  7. Frost, 2013, Marijuana use and long-term mortality among survivors of acute myocardial infarction, Am Heart J, 165, 170, 10.1016/j.ahj.2012.11.007 · DOI
  8. Caldicott, 2005, Keep off the grass: marijuana use and acute cardiovascular events, Eur J Emerg Med, 12, 236, 10.1097/00063110-200510000-00008 · DOI
  9. McIlroy, 2016, Acute myocardial infarction, associated with the use of a synthetic adamantyl-cannabinoid: a case report, BMC Pharmacol Toxicol, 17, 2, 10.1186/s40360-016-0045-1 · DOI
  10. Yurtdas, 2012, Acute myocardial infarction in a young man; fatal blow of the marijuana: a case report, Korean Circ J, 42, 641, 10.4070/kcj.2012.42.9.641 · DOI
  11. Keskin, 2016, Acute myocardial infarction and ischemic stroke coexistence due to marijuana abuse in an adolescent, Anatol J Cardiol, 16, 542
  12. Tatli, 2007, Cannabis-induced coronary artery thrombosis and acute anterior myocardial infarction in a young man, Int J Cardiol, 120, 420, 10.1016/j.ijcard.2006.08.012 · DOI
  13. McLeod, 2002, Myocardial infarction following the combined recreational use of Viagra and cannabis, Clin Cardiol, 25, 133, 10.1002/clc.4960250310 · DOI
  14. Taher, 2006, Acute myocardial infarction in a young man: a consequence of inherited thrombophilia and marijuana smoking, Thromb Haemost, 95, 1044, 10.1160/TH06-03-0169 · DOI
  15. Hamilton, 2017, Synthetic cannabinoid abuse resulting in ST-Segment elevation myocardial infarction requiring percutaneous coronary intervention, J Emerg Med, 52, 496, 10.1016/j.jemermed.2016.09.023 · DOI
  16. Dahdouh, 2012, Cannabis and coronary thrombosis: what is the role of platelets?, Platelets, 23, 243, 10.3109/09537104.2011.601824 · DOI
  17. Kocabay, 2009, Acute inferior myocardial infarction due to cannabis smoking in a young man, J Cardiovasc Med (Hagerstown), 10, 669, 10.2459/JCM.0b013e32832bcfbe · DOI
  18. Cappelli, 2008, Cannabis: a trigger for acute myocardial infarction? A case report, J Cardiovasc Med (Hagerstown), 9, 725, 10.2459/JCM.0b013e3282f2cd0d · DOI
  19. Hodcroft, 2014, Cannabis-associated myocardial infarction in a young man with normal coronary arteries, J Emerg Med, 47, 277, 10.1016/j.jemermed.2013.11.077 · DOI
  20. Gunawardena, 2014, Myocardial infarction following cannabis induced coronary vasospasm, BMJ Case Rep, 2014, 10.1136/bcr-2014-207020 · DOI
  21. Canga, 2011, Cannabis: a rare trigger of premature myocardial infarction, Anadolu Kardiyol Derg, 11, 272
  22. Mills, 2018, Acute myocardial infarction triggered by use of synthetic cannabis, Proc (Bayl Univ Med Cent), 31, 200
  23. Orsini, 2016, Prolonged cardiac arrest complicating a massive ST-segment elevation myocardial infarction associated with marijuana consumption, J Community Hosp Intern Med Perspect, 6, 31695, 10.3402/jchimp.v6.31695 · DOI
  24. Ul Haq, 2017, “Spice” (Synthetic marijuana) induced acute myocardial infarction: a case series, Case Rep Cardiol, 2017
  25. Shah, 2016, Can your heart handle the spice: a case of acute myocardial infarction and left ventricular apical thrombus, Int J Cardiol, 215, 129, 10.1016/j.ijcard.2016.04.055 · DOI
  26. Velibey, 2015, Acute myocardial infarction due to marijuana smoking in a young man: guilty should not be underestimated, Am J Emerg Med, 33, 1114, 10.1016/j.ajem.2015.01.032 · DOI
  27. McKeever, 2015, K2–not the spice of life; synthetic cannabinoids and ST elevation myocardial infarction: a case report, J Med Toxicol, 11, 129, 10.1007/s13181-014-0424-1 · DOI
  28. Arora, 2012, ST-segment elevation myocardial infarction in a 37-year-old man with normal coronaries–it is not always cocaine!, Am J Emerg Med, 30, 2091, 10.1016/j.ajem.2011.12.033 · DOI
  29. Safaa, 2012, Marijuana-induced recurrent acute coronary syndrome with normal coronary angiograms, Drug Alcohol Rev, 31, 91, 10.1111/j.1465-3362.2011.00327.x · DOI
  30. Casier, 2014, Is recent cannabis use associated with acute coronary syndromes? An illustrative case series, Acta Cardiol, 69, 131, 10.1080/AC.69.2.3017293 · DOI
  31. Wengrofsky, 2018, Recurrent STEMI precipitated by marijuana use: case report and literature review, Am J Med Case Rep, 6, 163, 10.12691/ajmcr-6-8-5 · DOI
  32. Tirkey, 2016, Acute antero-inferior wall ischaemia with acute ischaemic stroke caused by oral ingestion of cannabis in a young male, J Assoc Physicians India, 64, 93
  33. Yilmaz, 2015, Acute anterior myocardial infarction after “Bonzai” use, Anatol J Cardiol, 15, 265, 10.5152/akd.2015.5994 · DOI
  34. Tormey, 2012, Cannabis misinterpretation and misadventure in a coroner's court, Med Sci Law, 52, 229, 10.1258/msl.2011.011087 · DOI
  35. Zaleta, 2016, Chest pain, troponin rise, and ST-elevation in an adolescent boy following the use of the synthetic cannabis product K2, Ann Pediatr Cardiol, 9, 79, 10.4103/0974-2069.171400 · DOI
  36. Jehangir, 2015, Did cannabis precipitate an STEMI in a young woman?, Cardiol Res., 6, 283, 10.14740/cr398w · DOI
  37. Marchetti, 2016, Coronary thrombosis and marijuana smoking: a case report and narrative review of the literature, Drug Test Anal, 8, 56, 10.1002/dta.1898 · DOI
  38. Collins, 1985, Myocardial infarction during marijuana smoking in a young female, Eur Heart J, 6, 637, 10.1093/oxfordjournals.eurheartj.a061913 · DOI
  39. Papp, 2005, Drug-induced myocardial infarction in young patients: report of two cases, Int J Cardiol, 98, 169, 10.1016/j.ijcard.2003.12.019 · DOI
  40. Tse, 2014, Sudden cardiac death complicating acute myocardial infarction following synthetic cannabinoid use, Intern Med J, 44, 934, 10.1111/imj.12521 · DOI
  41. Karabulut, 2010, ST segment elevation myocardial infarction due to slow coronary flow occurring after cannabis consumption, Kardiol Pol, 68, 1266
  42. Koklu, 2015, A new cause of silent myocardial infarction: bonsai, Anatol J Cardiol, 15, 69, 10.5152/akd.2014.5870 · DOI
  43. Inci, 2015, Bonsai-induced Kounis syndrome in a young male patient, Anatol J Cardiol, 15, 952, 10.5152/AnatolJCardiol.2015.6641 · DOI
  44. Lindsay, 2005, Cannabis as a precipitant of cardiovascular emergencies, Int J Cardiol, 104, 230, 10.1016/j.ijcard.2004.10.038 · DOI
  45. Schmid, 2011, Spontaneous coronary artery dissection in a young man—case report, J Cardiothorac Surg, 6, 22, 10.1186/1749-8090-6-22 · DOI
  46. Mir, 2011, Myocardial infarction associated with use of the synthetic cannabinoid K2, Pediatrics, 128, e1622, 10.1542/peds.2010-3823 · DOI
  47. Ayhan, 2014, [Bonsai induced acute myocardial infarction], Turk Kardiyol Dern Ars, 42, 560, 10.5543/tkda.2014.70670 · DOI
  48. Clark, 2015, Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients, J Pediatr, 167, 757, 10.1016/j.jpeds.2015.06.001 · DOI
  49. Renard, 2012, Cannabis-related myocardial infarction and cardioembolic stroke, J Stroke Cerebrovasc Dis, 21, 82, 10.1016/j.jstrokecerebrovasdis.2010.04.002 · DOI
  50. Atik, 2015, Cardiovascular side effects related with use of synthetic cannabinoids “bonzai”: two case reports, Turk Pediatri Ars, 50, 61, 10.5152/tpa.2015.2609 · DOI
  51. Filali, 2013, Spontaneous multivessel coronary artery dissection associated with cannabis use, J Cardiol Cases, 7, e4
  52. Choi, 1989, Cardiovascular effects of adolescent drug abuse, J Adolesc Health Care, 10, 332, 10.1016/0197-0070(89)90068-5 · DOI
  53. Toce, 2018, Myocardial infarct after marijuana inhalation in a 16-year-old adolescent boy, Pediatr Dev Pathol
  54. DeFilippis, 2018, Cocaine and marijuana use among young adults with myocardial infarction, J Am Coll Cardiol, 71, 2540, 10.1016/j.jacc.2018.02.047 · DOI
  55. Fisher, 2005, Cardiovascular complications induced by cannabis smoking: a case report and review of the literature, Emerg Med J, 22, 679, 10.1136/emj.2004.014969 · DOI
  56. Gash, 1978, Effects of smoking marihuana on left ventricular performance and plasma norepinephrine: studies in normal men, Ann Intern Med, 89, 448, 10.7326/0003-4819-89-4-448 · DOI
  57. Kanakis, 1976, The effects of delta-9-tetrahydrocannabinol (cannabis) on cardiac performance with and without beta blockade, Circulation, 53, 703, 10.1161/01.CIR.53.4.703 · DOI
  58. Beaconsfield, 1972, Marihuana smoking. cardiovascular effects in man and possible mechanisms, N Engl J Med, 287, 209, 10.1056/NEJM197208032870501 · DOI
  59. Renault, 1971, Marihuana: standardized smoke administration and dose effect curves on heart rate in humans, Science, 174, 589, 10.1126/science.174.4009.589 · DOI
  60. Weiss, 1972, Cardiovascular effects of delta-9-tetrahydrocannabinol in man, Clin Pharmacol Ther, 13, 671, 10.1002/cpt1972135part1671 · DOI
  61. Alshaarawy, 2016, Cannabis use and blood pressure levels: united states national health and nutrition examination survey, 2005-2012, J Hypertens, 34, 1507, 10.1097/HJH.0000000000000990 · DOI
  62. Sulkowski, 1977, Propranolol effects on acute marihuana intoxication in man, Psychopharmacol (Berl), 52, 47, 10.1007/BF00426599 · DOI
  63. Aronow, 1975, Effect of smoking marihuana and of a high-nicotine cigarette on angina pectoris, Clin Pharmacol Ther, 17, 549, 10.1002/cpt1975175549 · DOI
  64. Shah, 2003, Mechanisms of plaque vulnerability and rupture, J Am Coll Cardiol, 41, 15S, 10.1016/S0735-1097(02)02834-6 · DOI
  65. Deusch, 2004, The procoagulatory effects of delta-9-tetrahydrocannabinol in human platelets, Anesth Analg, 99, 1127, 10.1213/01.ANE.0000131505.03006.74 · DOI
  66. Dewey, 1986, Cannabinoid pharmacology, Pharmacol Rev, 38, 151, 10.1016/S0031-6997(25)06864-4 · DOI
  67. Randall, 2007, Endocannabinoids and the haematological system, Br J Pharmacol, 152, 671, 10.1038/sj.bjp.0707420 · DOI
  68. Aryana, 2007, Marijuana as a trigger of cardiovascular events: speculation or scientific certainty?, Int J Cardiol, 118, 141, 10.1016/j.ijcard.2006.08.001 · DOI
  69. Rezkalla, 2003, Coronary no-flow and ventricular tachycardia associated with habitual marijuana use, Ann Emerg Med, 42, 365, 10.1016/S0196-0644(03)00426-8 · DOI
  70. Wang, 2016, One minute of marijuana secondhand smoke exposure substantially impairs vascular endothelial function, J Am Heart Assoc, 5, 10.1161/JAHA.116.003858 · DOI
  71. Basnet, 2009, Coronary vasospasm in an adolescent resulting from marijuana use, Pediatr Cardiol, 30, 543, 10.1007/s00246-009-9384-7 · DOI
  72. Hoyte, 2012, A characterization of synthetic cannabinoid exposures reported to the national poison data system in 2010, Ann Emerg Med, 60, 435, 10.1016/j.annemergmed.2012.03.007 · DOI

Cited by

Sorted by citations

See all 67

Metadata

Authors
Patel, R. S., Kamil, S. H., Bachu, R., Adikey, A., Ravat, V., Kaur, M., Tankersley, W. E., & Goyal, H.
Affiliations
  • Oklahoma Department of Mental Health and Substance Abuse Services (US)
  • Baptist Health Foundation (US)
  • Carilion Clinic (US)
  • Larkin Community Hospital (US)
  • American University of Antigua (AG)
  • The Wright Center for Graduate Medical Education (US)
Corresponding author
Goyal, Hemant
ORCID
Venue
Trends in Cardiovascular Medicine
Publisher
Elsevier BV
Published
2020-07
Volume
30
Issue
5
Pages
298-307
ISSN
1050-1738 (ISSN-L)
DOI
10.1016/j.tcm.2019.08.003
OpenAlex
W2967967032
Cited by
67
References
0
Citations by year
2026: 3 · 2025: 7 · 2024: 5 · 2023: 12 · 2022: 12 · 2021: 16 · 2020: 11
FWCI
1.81
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Trends in Cardiovascular Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
International Business Machines Corporation
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
cannabis use, acute myocardial infarction, cannabis, coronary artery occlusion, left anterior descending artery, percutaneous coronary intervention, thrombectomy, cardioembolic stroke, mortality, young adults
MeSH terms
Adolescent, Adult, Cannabinoids, Marijuana Abuse, Coronary Artery Disease, Female, Humans, Male, Marijuana Smoking, Middle Aged, Myocardial Infarction, Prognosis, Risk Factors, Risk Assessment, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Marijuana use and acute myocardial infarction: A systematic review of published cases in the literature. https://app.cochat.ai/papers/10.1016/j.tcm.2019.08.003
The paper
Patel, R. S., Kamil, S. H., Bachu, R., Adikey, A., Ravat, V., Kaur, M., Tankersley, W. E., & Goyal, H. (2020). Marijuana use and acute myocardial infarction: A systematic review of published cases in the literature. Trends in Cardiovascular Medicine. https://doi.org/10.1016/j.tcm.2019.08.003