Focus on prolactin as a metabolic hormone

Prolactin: structure, function, and regulation of secretion

Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457

Understanding Adipocyte Differentiation

GREGOIRE, F. M., SMAS, C. M., & SUL, H. S. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.783 · Cited by 2,376

Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice

Bole-Feysot, C., Goffin, V., Edery, M., Binart, N., & Kelly, P. A. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0334 · Cited by 1,938

Extrapituitary Prolactin: Distribution, Regulation, Functions, and Clinical Aspects*

BEN-JONATHAN, N., MERSHON, J. L., ALLEN, D. L., & STEINMETZ, R. W. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-6-639 · Cited by 734

Circulating Interleukin‐6 in Relation to Adiposity, Insulin Action, and Insulin Secretion

Vozarova, B., Weyer, C., Hanson, K., Tataranni, P. A., Bogardus, C., & Pratley, R. E. (2001) · Obesity Research · doi:10.1038/oby.2001.54 · Cited by 639

Hormonal Regulation of Mammary Differentiation and Milk Secretion

Neville, M. C., McFadden, T. B., & Forsyth, I. (2002) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1015770423167 · Cited by 626

The Role of Prolactin in Mammary Carcinoma

Clevenger, C. V., Furth, P. A., Hankinson, S. E., & Schuler, L. A. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0036 · Cited by 545

Sexual Differentiation, Pregnancy, Calorie Restriction, and Aging Affect the Adipocyte-Specific Secretory Protein Adiponectin

Combs, T. P., Berg, A. H., Rajala, M. W., Klebanov, S., Iyengar, P., Jimenez-Chillaron, J. C., Patti, M. E., Klein, S. L., Weinstein, R. S., & Scherer, P. E. (2003) · Diabetes · doi:10.2337/diabetes.52.2.268 · Cited by 544

Adaptation of Islets of Langerhans to Pregnancy: β-Cell Growth, Enhanced Insulin Secretion and the Role of Lactogenic Hormones

Sorenson, R., & Brelje, T. (1997) · Hormone and Metabolic Research · doi:10.1055/s-2007-979040 · Cited by 531

Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice

Bôle‐Feysot, C. (1998) · Endocrine Reviews · doi:10.1210/er.19.3.225 · Cited by 477

The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones

ARNER, P. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00024-9 · Cited by 423

Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance

Freemark, M. (2002) · Endocrinology · doi:10.1210/en.143.4.1378 · Cited by 258

Increased body weight associated with prolactin secreting pituitary adenomas: weight loss with normalization of prolactin levels

Greenman, Y., Tordjman, K., & Stern, N. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00403.x · Cited by 227

Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue

Nilsson, L., Binart, N., Bohlooly-Y, M., Bramnert, M., Egecioglu, E., Kindblom, J., Kelly, P. A., Kopchick, J. J., Ormandy, C. J., Ling, C., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.04.026 · Cited by 191

Dopaminergic tone and obesity: an insight from prolactinomas treated with bromocriptine

Doknic, M., Pekic, S., Zarkovic, M., Medic-Stojanoska, M., Dieguez, C., Casanueva, F., & Popovic, V (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470077 · Cited by 172

Body Weight and Fat Deposition in Prolactin Receptor-Deficient Mice

Freemark, M., Fleenor, D., Driscoll, P., Binart, N., & Kelly, P. A. (2001) · Endocrinology · doi:10.1210/endo.142.2.7979 · Cited by 151

Identification of Functional Prolactin (PRL) Receptor Gene Expression: PRL Inhibits Lipoprotein Lipase Activity in Human White Adipose Tissue

Ling, C., Svensson, L., Odén, B., Weijdegård, B., Edén, B., Edén, S., & Billig, H. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021137 · Cited by 145

Distinctive roles for prolactin and growth hormone in the activation of signal transducer and activator of transcription 5 in pancreatic islets of langerhans

Brelje, T. C., Stout, L. E., Bhagroo, N. V., & Sorenson, R. L. (2004) · Endocrinology · doi:10.1210/en.2004-0201 · Cited by 134

Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms

Schuff, K. G., Hentges, S. T., Kelly, M. A., Binart, N., Kelly, P. A., Iuvone, P. M., Asa, S. L., & Low, M. J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15912 · Cited by 133

The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation

Royster, M., Driscoll, P., Kelly, P. A., & Freemark, M. (1995) · Endocrinology · doi:10.1210/endo.136.9.7649097 · Cited by 128

Glucokinase, hexokinase, glucose transporter 2, and glucose metabolism in islets during pregnancy and prolactin-treated islets in vitro: mechanisms for long term up-regulation of islets

Weinhaus, A. J., Stout, L. E., & Sorenson, R. L. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612496 · Cited by 120

Participation of prolactin receptors and phosphatidylinositol 3-kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to glucose during pregnancy

Amaral, M. E. C., Cunha, D. A., Anhê, G. F., Ueno, M., Carneiro, E. M., Velloso, L. A., Bordin, S., & Boschero, A. C. (2004) · Journal of Endocrinology · doi:10.1677/joe.1.05547 · Cited by 110

Prolactin Release Is Enhanced in Proportion to Excess Visceral Fat in Obese Women

Kok, P., Roelfsema, F., Frölich, M., Meinders, A. E., & Pijl, H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032184 · Cited by 108

Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms

Schuff, K. G., Hentges, S. T., Kelly, M. A., Binart, N., Kelly, P. A., Iuvone, P. M., Asa, S. L., & Low, M. J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215912 · Cited by 108

Development of lipoprotein lipase activity and accumulation of triacylglycerol in differentiating 3T3-L1 adipocytes. Effects of prostaglandin F2alpha, 1-methyl-3-isobutylxanthine, prolactin, and insulin.

Spooner, P. M., Chernick, S. S., GARRISON, M. M., et al. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34203-5 · Cited by 107

Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development.

Freemark, M., Driscoll, P., Maaskant, R. A., Petryk, A., & Kelly, P. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119239 · Cited by 103

Stimulation of food intake and weight gain in mature female rats by bovine prolactin and bovine growth hormone

Byatt, J. C., Staten, N. R., Salsgiver, W. J., et al. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.6.e986 · Cited by 98

The role of growth hormone, prolactin and insulin-like growth factors in the regulation of rat mammary gland and adipose tissue metabolism during lactation

BARBER, M. C., CLEGG, R. A., Finley, E., et al. (1992) · Journal of Endocrinology · doi:10.1677/joe.0.1350195 · Cited by 98

Prolactin Expression and Secretion by Human Breast Glandular and Adipose Tissue Explants

Zinger, M., McFarland-Mancini, M. M., & Ben‐Jonathan, N. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021255 · Cited by 97

Prolactin Enhances CCAAT Enhancer-Binding Protein- (C/EBP ) and Peroxisome Proliferator-Activated Receptor (PPAR ) Messenger RNA Expression and Stimulates Adipogenic Conversion of NIH-3T3 Cells

Nanbu-Wakao, R., Fujitani, Y., Masuho, Y., Muramatu, M.-A., & Wakao, H. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.2.0420 · Cited by 96

Hyperprolactinemia stimulates food intake in the female rat

MOORE, B. J., Gerardo-Gettens, T., Horwitz, B. A., & Stern, J. S. (1986) · Brain Research Bulletin · doi:10.1016/0361-9230(86)90226-1 · Cited by 95

Prolactin (PRL) Receptor Gene Expression in Mouse Adipose Tissue: Increases during Lactation and in PRL-Transgenic Mice1

Ling, C., Hellgren, G., Gebre‐Medhin, M., Dillner, K., Wennbo, H., Carlsson, B., & Billig, H. (2000) · Endocrinology · doi:10.1210/endo.141.10.7691 · Cited by 94

The Regulation of Fatty Acid Synthase by STAT5A

Hogan, J. C., & Stephens, J. M. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1968 · Cited by 94

Prolactin receptors and JAK2 in islets of Langerhans: an immunohistochemical analysis

Sorenson, R. L., & Stout, L. E. (1995) · Endocrinology · doi:10.1210/endo.136.9.7649117 · Cited by 86

Neuroanatomical specificity of prolactin-induced hyperphagia in virgin female rats

Sauvé, D., & Woodside, B. C. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02344-1 · Cited by 83

Prolactin and the regulation of adipose-tissue metabolism during lactation in rats

Flint, D. J., CLEGG, R. A., & Vernon, R. G. (1981) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(81)90096-4 · Cited by 83

LS14: A Novel Human Adipocyte Cell Line that Produces Prolactin

Hugo, E. R., Brandebourg, T. D., Comstock, C. E. S., Gersin, K. S., SUSSMAN, J. S., & Ben‐Jonathan, N. (2005) · Endocrinology · doi:10.1210/en.2005-0989 · Cited by 80

Effects of Growth Hormone and Prolactin on Adipose Tissue Development and Function

Flint, D. J., Binart, N., Kopchick, J. J., & Kelly, P. A. (2003) · Pituitary · doi:10.1023/b:pitu.0000004800.57449.67 · Cited by 79

Testosterone and Prolactin Regulation of Metabolic Genes and Citrate Metabolism of Prostate Epithelial Cells

Costello, L. C., & FRANKLIN, R. B. (2002) · Hormone and Metabolic Research · doi:10.1055/s-2002-33598 · Cited by 74

Prolactin Induction of Insulin Gene Transcription: Roles of Glucose and Signal Transducer and Activator of Transcription 5

Fleenor, D. E., & Freemark, M. (2001) · Endocrinology · doi:10.1210/endo.142.7.8267 · Cited by 72

Prolactin Receptor Gene Expression and Foetal Adipose Tissue

Symonds, M. E., Phillips, Anthony, Owens, J. A., & McMillen (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00275.x · Cited by 69

PRL Signal Transduction in the Epithelial Compartment of Rat Prostate Maintained as Long-Term Organ Cultures in Vitro

Ahonen, T. J., Härkönen, P. L., Rui, H., & Nevalainen, M. T. (2002) · Endocrinology · doi:10.1210/endo.143.1.8576 · Cited by 64

Prolactin induction of insulin gene expression: the roles of glucose and glucose transporter-2

Petryk, A., Fleenor, D. E., Driscoll, P., & Freemark, M. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1640277 · Cited by 64

PRL Receptor-Mediated Effects in Female Mouse Adipocytes: PRL Induces Suppressors of Cytokine Signaling Expression and Suppresses Insulin-Induced Leptin Production in Adipocytes in Vitro

Ling, C., & Billig, H. (2001) · Endocrinology · doi:10.1210/en.142.11.4880 · Cited by 63

Prolactin receptor expression during adipocyte differentiation of bone marrow stroma

McAveney, K. M., Gimble, J. M., & Yu‐Lee, L. (1996) · Endocrinology · doi:10.1210/en.137.12.5723 · Cited by 62

STAT 5 activators can replace the requirement of FBS in the adipogenesis of 3T3-L1 cells

Stewart, W. C., Baugh, J. E., Floyd, Z. E., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.053 · Cited by 60

Roles of the Lactogens and Somatogens in Perinatal and Postnatal Metabolism and Growth: Studies of a Novel Mouse Model Combining Lactogen Resistance and Growth Hormone Deficiency

Fleenor, D. E., Oden, J., Kelly, P. A., Mohan, S., Alliouachene, S., Pende, M., Wentz, S. C., Kerr, J., & Freemark, M. (2004) · Endocrinology · doi:10.1210/en.2004-0744 · Cited by 58

Prolactin-modulated gene expression profiles in pancreatic islets from adult female rats

Bordin, S. A., do Amaral, M. E. C., Anhê, G. F., Delghingaro‐Augusto, V., Cunha, D. A., Nicoletti-Carvalho, J. E., & Boschero, A. C. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.04.001 · Cited by 55

Prolactin, progesterone, and dexamethasone coordinately and adversely regulate glucokinase and cAMP/PDE cascades in MIN6 β-cells

Shao, J., Qiao, L., & Friedman, J. E. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00210.2003 · Cited by 55

Comparative effects of the antipsychotics sulpiride and risperidone in female rats on energy balance, body composition, fat morphology and macronutrient selection

Baptista, T., de Baptista, E. A., Lalonde, J., Plamondon, J., Kin, N. M. K. N. Y., Beaulieu, S., Joober, R., & Richard, D. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.08.001 · Cited by 54

Dopamine and Prolactin in Human Pregnancy*

Jonathan, N. B., & Munsick, R. A. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-5-1019 · Cited by 44

The Comparative Biology of Whey Proteins

Simpson, K. J., & Nicholas, K. R. (2002) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1022856801175 · Cited by 41

Bioactive and immunoreactive prolactin variants in human milk.

Ellis, L. A., & Picciano, M. F. (1995) · Endocrinology · doi:10.1210/endo.136.6.7750496 · Cited by 40

Prolactin potentiates insulin-stimulated leptin expression and release from differentiated brown adipocytes

Viengchareun, S., Bouzinba-Ségard, H., Laigneau, J. P., Zennaro, M., Kelly, P. A., Bado, A., Lombès, M., & Binart, N. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01563 · Cited by 36

Chronic effect of hyperprolactinemia on blood glucose and lipid levels in mice

Matsuda, M., Mori, T., Sassa, S., Sakamoto, S., Park, M. K., & Kawashima, S. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00075-6 · Cited by 33

Prolactin (PRL) Receptor Gene Expression in Mouse Adipose Tissue: Increases during Lactation and in PRL-Transgenic Mice

Ling, C. (2000) · Endocrinology · doi:10.1210/en.141.10.3564 · Cited by 32

Prolactin Enhances CCAAT Enhancer-Binding Protein- (C/EBP ) and Peroxisome Proliferator-Activated Receptor (PPAR ) Messenger RNA Expression and Stimulates Adipogenic Conversion of NIH-3T3 Cells

Nanbu-Wakao, R. (2000) · Molecular Endocrinology · doi:10.1210/me.14.2.307 · Cited by 22

Effects of hypersecretion of growth hormone and prolactin on plasma levels of glucagon and insulin in GH3-cell-tumor-bearing rats, and the influence of bromocriptine treatment

Knudtzon, J., Johansen, P. W., Haug, E., & Gautvik, K. M. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90042-1 · Cited by 12

The secretory function of adipocytes in the physiology of white adipose tissue

Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318

Circulating Prolactin Associates With Diabetes and Impaired Glucose Regulation

Wang, T., Lu, J., Xu, Y., Li, M., Sun, J., Zhang, J., Xu, B., Xu, M., Chen, Y., Bi, Y., et al. (2013) · Diabetes Care · doi:10.2337/dc12-1893 · Cited by 148

Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells

Banerjee, R. R., Cyphert, H. A., Walker, E. M., Chakravarthy, H., Peiris, H., Gu, X., Liu, Y., Conrad, E., Goodrich, L., Stein, R. W., et al. (2016) · Diabetes · doi:10.2337/db15-1527 · Cited by 131

Effect of cabergoline on insulin sensitivity, inflammation, and carotid intima media thickness in patients with prolactinoma

Inancli, S. S., Usluogullari, A., Ustu, Y., Caner, S., Tam, A. A., Ersoy, R., & Cakir, B. (2013) · Endocrine · doi:10.1007/s12020-012-9857-y · Cited by 59

Sex hormone binding globulin, but not testosterone, is associated with the metabolic syndrome in overweight and obese women with polycystic ovary syndrome.

(2013) · PubMed · doi:10.3275/9023 · Cited by 48