The DOI matches its Crossref record; 65 of the 68 references it cites were found in a registry or an index.
Red not dead: signaling in and from erythrocytes
Abstract
The oxygen required to meet metabolic needs of all tissues is delivered by the erythrocyte, a small, flexible cell which, in mammals, is devoid of a nucleus and mitochondria. Despite its simple appearance, this 'bag of hemoglobin' has an important role in its own distribution, enabling the delivery of oxygen to precisely meet localized metabolic need. When an erythrocyte enters an area in which tissue oxygen demand exceeds supply, a signaling pathway is activated resulting in the release of adenosine 5'-triphosphate (ATP). This ATP acts in a paracrine fashion to increase vascular caliber resulting in increased oxygen delivery. Defects in this pathway are found in erythrocytes of humans with type 2 diabetes (DM2) and could contribute to the perfusion abnormalities in skeletal muscle associated with this disease.
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“Subsequently, several reports have shown that all mammalian Mo-containing enzymes [XO, aldehyde oxidase (AO), sulfite oxidase, and the mitochondrial amidoxime-reducing component (mARC)] are able to reduce nitrite at different intrinsic rates (Table 4) (575, 880, 990).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [880]
In the citing paper
“Both mARC enzymes can reduce nitrite to NO in a process very sensitive to oxygen-mediated inhibition (Table 4) (880).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [880]
Citations
Cites
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The erythrocyte as a regulator of vascular tone
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Self-citationRelease of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia
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Deformation-induced ATP release from red blood cells requires CFTR activity
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Yegutkin, G. G. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.024 · Cited by 1,155
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Extracellular ATP in the Immune System: More Than Just a “Danger Signal”
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Squeezing for Life – Properties of Red Blood Cell Deformability
Huisjes, R., Bogdanova, A. Y., van Solinge, W. W., Schiffelers, R. M., Kaestner, L., & van Wijk, R. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00656 · Cited by 331
“The oxygenation state of hemoglobin is known to influence various processes of the RBC (Gibson et al., 2000; Stefanovic et al., 2013).”
BackgroundInfluentialRegulation of Coronary Blood Flow
Goodwill, A. G., Dick, G. M., Kiel, A. M., & Tune, J. D. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160016 · Cited by 358
Metadata
- Authors
- Sprague, R. S., Stephenson, A. H., & Ellsworth, M. L.
- Affiliations
- Saint Louis University (US)
- ORCID
- Sprague, Randy S.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 18
- Issue
- 9
- Pages
- 350-355
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W1992160483
- Cited by
- 124
- References
- 68
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 11 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL051298, HL-51298, HL64180, R01HL056249, R01HL064180, HL56249, HL 39226)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- erythrocytes, ATP release, paracrine signaling, oxygen delivery, vascular caliber, type 2 diabetes, skeletal muscle perfusion
- MeSH terms
- Energy Metabolism, Erythrocytes, Humans, Oxygen, Signal Transduction
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