The DOI matches its Crossref record; 65 of the 68 references it cites were found in a registry or an index.
Red not dead: signaling in and from erythrocytes
Abstract
The oxygen required to meet metabolic needs of all tissues is delivered by the erythrocyte, a small, flexible cell which, in mammals, is devoid of a nucleus and mitochondria. Despite its simple appearance, this 'bag of hemoglobin' has an important role in its own distribution, enabling the delivery of oxygen to precisely meet localized metabolic need. When an erythrocyte enters an area in which tissue oxygen demand exceeds supply, a signaling pathway is activated resulting in the release of adenosine 5'-triphosphate (ATP). This ATP acts in a paracrine fashion to increase vascular caliber resulting in increased oxygen delivery. Defects in this pathway are found in erythrocytes of humans with type 2 diabetes (DM2) and could contribute to the perfusion abnormalities in skeletal muscle associated with this disease.
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“Subsequently, several reports have shown that all mammalian Mo-containing enzymes [XO, aldehyde oxidase (AO), sulfite oxidase, and the mitochondrial amidoxime-reducing component (mARC)] are able to reduce nitrite at different intrinsic rates (Table 4) (575, 880, 990).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [880]
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“Both mARC enzymes can reduce nitrite to NO in a process very sensitive to oxygen-mediated inhibition (Table 4) (880).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [880]
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Is there a direct role for erythrocytes in the immune response?
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Gironi, B., Kahveci, Z., McGill, B., Lechner, B., Pagliara, S., Metz, J., Morresi, A., Palombo, F., Sassi, P., & Petrov, P. G. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.05.037 · Cited by 115
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“Since CFTR activity is regulated by cAMP-dependent PKA, it has been also hypothesized that shear stress- and hypoxia-induced ATP release involves activation of the cAMP signaling pathway (Sprague et al., 2007).”
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BackgroundRevisiting the question of nucleated versus enucleated erythrocytes in birds and mammals
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“Moreover, when tissue oxygen is demanded, ATP released from the erythrocyte is utilized to increase vascular caliber so that oxygen delivery is facilitated [8,9].”
BackgroundFranke, R., Krüger, A., Scharnweber, T., Wenzel, F., & Jung, F. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150916134 · Cited by 13
“Band 3 is described to constitute a center organized into complexes for gas transport [41–44], anion exchanger, for glycolysis [43,45,46], for the control of cell volume [47] and of erythrocyte life span (senescence) [48], where most probably further complexes exist to cope with mechanical deformation [49], and haemos…”
BackgroundExploring the microvascular impact of red blood cell transfusion in intensive care unit patients
Hariri, G., Bourcier, S., Marjanovic, Z., Joffre, J., Lemarie, J., Lavillegrand, J., Charue, D., Duflot, T., Bigé, N., Baudel, J.-L., et al. (2019) · Critical Care · doi:10.1186/s13054-019-2572-9 · Cited by 13
Patch-Clamp Analysis of Membrane Transport in Erythrocytes
Bouyer, G., Thomas, S. L. Y., & Ege, S. (2012) · InTech eBooks · doi:10.5772/37279 · Cited by 10
“Indeed, description of these different channel types in RBCs, using patch clamp techniques, has raised many questions: how do they interfere with the regulation of intracellular homeostasis, cell differentiation or death? But their presence also fits with a new vision of red cells, being much more than an empty bag of…”
BackgroundCooperation of erythrocytes with leukocytes in immune response of a teleost Oplegnathus fasciatus
Jeong, J.-M., An, C. M., Kim, M., & Park, C. (2016) · Genes & Genomics · doi:10.1007/s13258-016-0437-z · Cited by 10
“Erythrocytes transport oxygen and carbon dioxide, which play significant roles in prevention of oxidative stress and control of blood flow to the skeletal muscles (Richards et al. 1998; Sprague et al. 2007; Tsantes et al. 2006).”
BackgroundMarginedas-Freixa, I., Alvarez, C. L., Moras, M., Hattab, C., Bouyer, G., Chêne, A., Lefevre, S. D., Kim, C. L. V., Bihel, F. J. ‐., Schwarzbaum, P. J., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103098 · Cited by 11
“ATP release from RBCs contributed to the control of the blood flow and tissue-oxygenation [32].”
BackgroundZhan, X., Zhong, X. Y., Choi, J. H., Su, L., Wang, J., Nair‐Gill, E., Anderton, P. D., Li, X., Tang, M., Russell, J. L., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020001762 · Cited by 9
“Erythrocytes can release ATP into plasma via a nonlytic pathway or via intravascular hemolysis under specific circumstances.(44,45) Although intracellular levels of ATP could reach millimolar concentrations, the extracellular ATP concentration in plasma is maintained at 2 or 3 magnitudes of order lower by ectonucleoti…”
BackgroundTownsend, A. D., Sprague, R. S., & Martin, R. S. (2019) · Electroanalysis · doi:10.1002/elan.201900157 · Cited by 9
Self-citationAlcicek, F. C., Mohaissen, T., Bułat, K., Dybaś, J., Szczęsny-Małysiak, E., Kaczmarska, M. J., Franczyk‐Żarów, M., Kostogrys, R. B., & Marzec, K. M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.839323 · Cited by 7
Sueyoshi, K., Sumi, Y., Inoue, Y., Kuroda, Y., Ishii, K., Nakayama, H., Iwabuchi, K., Kurishita, Y., Shigemitsu, H., Hamachi, I., et al. (2016) · Annals of Intensive Care · doi:10.1186/s13613-016-0175-z · Cited by 6
The Role of Platelets in Sickle Cell Disease
Brzóska, T., Kato, G. J., & Sundd, P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813456-6.00031-x · Cited by 6
Sprague, R. S., & Ellsworth, M. L. (2012) · Microcirculation · doi:10.1111/j.1549-8719.2012.00158.x · Cited by 6
Self-citationIntravascular hemolysis: the sacrifice of few…
Thomas, S. L. Y. (2014) · Blood · doi:10.1182/blood-2014-08-595447 · Cited by 6
Man, Y., Wu, D. H., An, R., Wei, P., Monchamp, K., Goreke, U., Sekyonda, Z., Wulftange, W. J., Federici, C., Bode, A., et al. (2023) · Sensors & Diagnostics · doi:10.1039/d2sd00095d · Cited by 5
Kay, L., Tokarska-Schlattner, M., Quenot-Carrias, B., Goudet, B., Bugert, P., Arnold, H., Scheuerbrandt, G., & Schlattner, U. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.03.008 · Cited by 5
Buerk, D. G., Liu, Y., Zaccheo, K. A., Barbee, K. A., & Jaron, D. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01053 · Cited by 6
“They suggest that a significant amount of NO might be transferred to the vasculature from this pool, avoiding quenching by Hb. Alternately, there is evidence that the RBC releases ATP during hypoxia, which can in turn stimulate NO production by eNOS (Sprague et al., 2007; Cao et al., 2009).”
BackgroundBirulina, Y. G., Петрова, И. В., Rozenbaum, Y. A., Shefer, E. A., Smagliy, L. V., Носарев, А. В., & Gusakova, S. V. (2019) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-019-04561-6 · Cited by 5
ATP release from erythrocytes: A role of adenosine1
Misiti, F., Carelli‐Alinovi, C., & Rodio, A. (2022) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-221379 · Cited by 5
“Previously, it was reported that in pathological erythrocytes, low basal cAMP levels correlate with a reduced ability to release ATP from erythrocytes under hypoxic conditions [37].”
Mysteries in the Local Control of Blood Flow
Chilian, W. M., Yin, L., & Ohanyan, V. A. (2012) · Circulation Research · doi:10.1161/circresaha.112.273060 · Cited by 5
Chmielewski, P. P., Strzelec, B., Chmielowiec, J., Chmielowiec, K., & Borysławski, K. (2017) · Anthropological Review · doi:10.1515/anre-2017-0012 · Cited by 4
“…acting as acid-base buffer, producing nitric oxide, S-nitrosothiol, and certain enzymes, promoting normal blood flow through releasing substances that relax and dilate blood vessels, etc. (Richards et al. 1998; Fonseca et al. 2003; Sprague et al. 2007; Morera and MacKenzie 2011; Jelkmann 2012).”
BackgroundTikhonova, L. A., Maevsky, E. I., Montoliú, C., & Kosenko, E. A. (2025) · Biomolecules · doi:10.3390/biom15040588 · Cited by 3
“The steady-state level of ATP depends not only on the rate of its formation but also on the activation of endogenous ATP-dependent reactions and on the release of ATP following exposure to β -adrenergic stimulation, reduced erythrocyte deformability and oxygen tension, or acidosis [110].”
Hypoxia induces robust ATP release from erythrocytes in ApoE-LDLR double-deficient mice
Alcicek, F. C., Dybaś, J., Bułat, K., Mohaissen, T., Szczęsny-Małysiak, E., Franczyk‐Żarów, M., & Marzec, K. M. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1497346 · Cited by 3
“…that investigated hypoxia-induced ATP release from RBCs (Ellsworth et al., 1995; Dietrich et al., 2000; Olearczyk et al., 2004b; Sprague et al., 2009; Sprague et al., 2010) and uncovered the responsible components in its signal-transduction pathway (Sprague et al., 2007; Sridharan et al., 2010).”
Evolution of potential biomarkers of acute muscle injury after physical exercise
Chielle, E. O., Granella, L. W., Maziero, J. S., Vidigal, T. M. A., Mallmann, B. L. K., & Karal, J. (2019) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902019000117594 · Cited by 3
Anhidrasa carbónica, nuevas perspectivas
Monroy, L. E., & Vargas, M. P. S. (2010) · NCT Neumología y Cirugía de Tórax · Cited by 3
The red blood cell: An underestimated actor in alterations of the microcirculation*
Piagnerelli, M. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e318196fd86 · Cited by 3
Inoue, M. (2025) · The Receptors · doi:10.1007/978-3-031-81991-9_7 · Cited by 2
Balzan, S., Carpi, A., Evangelista, M., Nicolini, G., Pollastri, A., Bottoni, A., & Iervasi, G. (2011) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2011.03.002 · Cited by 2
“and, consequently, to a reduced hemoglobin oxygen content [1].”
BackgroundFurst, B. (2013) · Springer eBooks · doi:10.1007/978-1-4471-5277-4_21 · Cited by 1
Metadata
- Authors
- Sprague, R. S., Stephenson, A. H., & Ellsworth, M. L.
- Affiliations
- Saint Louis University (US)
- ORCID
- Sprague, Randy S.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 18
- Issue
- 9
- Pages
- 350-355
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W1992160483
- Cited by
- 124
- References
- 68
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 11 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 8
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL051298, HL-51298, HL64180, R01HL056249, R01HL064180, HL56249, HL 39226)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- erythrocytes, ATP release, paracrine signaling, oxygen delivery, vascular caliber, type 2 diabetes, skeletal muscle perfusion
- MeSH terms
- Energy Metabolism, Erythrocytes, Humans, Oxygen, Signal Transduction
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