The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
What are lipoproteins doing in the brain?
Open accessAbstract
Lipoproteins in plasma transport lipids between tissues, however, only high-density lipoproteins (HDL) appear to traverse the blood-brain barrier (BBB); thus, lipoproteins found in the brain must be produced within the central nervous system. Apolipoproteins E (ApoE) and ApoJ are the most abundant apolipoproteins in the brain, are mostly synthesized by astrocytes, and are found on HDL. In the hippocampus and other brain regions, lipoproteins help to regulate neurobehavioral functions by processes that are lipoprotein receptor-mediated. Moreover, lipoproteins and their receptors also have roles in the regulation of body weight and energy balance, acting through lipoprotein lipase (LPL) and the low-density lipoprotein (LDL) receptor-related protein (LRP). Thus, understanding lipoproteins and their metabolism in the brain provides a new opportunity with potential therapeutic relevance.
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“Most cholesterol in CNS is synthesized in situ, because the transport of lipoprotein-mediated peripheral cholesterol to brain is blocked by BBB [29, 30].”
From MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease (2016) · cites this paper as [30]
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“Homeostatic GVU regulation in APOEch seems to be determined by CLU and APOE gene expression, possibly via cholesterol efflux and lipid regulation on the BBB [125]”
From Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection (2023) · cites this paper as [125]
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Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease
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Lipoprotein lipase: from gene to obesity
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Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning
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Pellegrini, L., Albecka, A., Mallery, D. L., Kellner, M. J., Paul, D., Carter, A. P., James, L. C., & Lancaster, M. A. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.10.001 · Cited by 562
Physiological regulation of lipoprotein lipase
Kersten, S. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.03.013 · Cited by 574
ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion
Huang, Y.-W. A., Zhou, B., Wernig, M., & Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2016.12.044 · Cited by 528
Age-associated Physiological and Pathological Changes at the Blood-Brain Barrier: A Review
Erdő, F., Denes, L., & de Lange, E. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16679420 · Cited by 426
Ahn, S. I., Sei, Y. J., Park, H., Kim, J., Ryu, Y., Choi, J. J., Sung, H., MacDonald, T. J., Levey, A. I., & Kim, Y. (2020) · Nature Communications · doi:10.1038/s41467-019-13896-7 · Cited by 414
Metadata
- Authors
- Wang, H., & Eckel, R. H.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Wang, Hong
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 25
- Issue
- 1
- Pages
- 8-14
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC4062975
- OpenAlex
- W1994756206
- Cited by
- 234
- References
- 68
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 14 · 2023: 24 · 2022: 25 · 2021: 29 · 2020: 27 · 2019: 8 · 2018: 14 · 2017: 15 · 2016: 12 · 2015: 18 · 2014: 11
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089309)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- lipoproteins, brain, high-density lipoprotein, apolipoprotein E, clusterin, blood-brain barrier, astrocytes, lipoprotein receptors, hippocampus, neurobehavior, energy balance, lipoprotein lipase, LDL receptor-related protein, lipoprotein metabolism
- MeSH terms
- Animals, Apolipoproteins E, Blood-Brain Barrier, Brain, Humans, Lipoprotein Lipase, Lipoproteins, Neurons, Receptors, LDL, CD36 Antigens, Membrane Microdomains, Low Density Lipoprotein Receptor-Related Protein-1, Mice
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