Cited by 234Barrier Structure and Function StudiesCholesterol and Lipid MetabolismLipid metabolism and disorders

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What are lipoproteins doing in the brain?

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Wang, Hong, Eckel, Robert H.·2014·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2013.10.003PMC PMC4062975

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Abstract

Lipoproteins in plasma transport lipids between tissues, however, only high-density lipoproteins (HDL) appear to traverse the blood-brain barrier (BBB); thus, lipoproteins found in the brain must be produced within the central nervous system. Apolipoproteins E (ApoE) and ApoJ are the most abundant apolipoproteins in the brain, are mostly synthesized by astrocytes, and are found on HDL. In the hippocampus and other brain regions, lipoproteins help to regulate neurobehavioral functions by processes that are lipoprotein receptor-mediated. Moreover, lipoproteins and their receptors also have roles in the regulation of body weight and energy balance, acting through lipoprotein lipase (LPL) and the low-density lipoprotein (LDL) receptor-related protein (LRP). Thus, understanding lipoproteins and their metabolism in the brain provides a new opportunity with potential therapeutic relevance.

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“However, lipid metabolism in the central nervous system (CNS) largely differs from the peripheral tissues, because the CNS is separated from the peripheral system by the bloodbrain barrier (BBB) [7].”
BackgroundInfluential

Authors: Wang, H., & Eckel, R. H.
Affiliations: University of Colorado Anschutz (US)
Corresponding author: Wang, Hong
ORCID: Wang, Hong
Eckel, Robert H.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2014-01
Volume: 25
Issue: 1
Pages: 8-14
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2013.10.003
PMC: PMC4062975
OpenAlex: W1994756206
Cited by: 234
References: 68
Citations by year: 2026: 17 · 2025: 19 · 2024: 14 · 2023: 24 · 2022: 25 · 2021: 29 · 2020: 27 · 2019: 8 · 2018: 14 · 2017: 15 · 2016: 12 · 2015: 18 · 2014: 11
FWCI: 1.32
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089309)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: lipoproteins, brain, high-density lipoprotein, apolipoprotein E, clusterin, blood-brain barrier, astrocytes, lipoprotein receptors, hippocampus, neurobehavior, energy balance, lipoprotein lipase, LDL receptor-related protein, lipoprotein metabolism
MeSH terms: Animals, Apolipoproteins E, Blood-Brain Barrier, Brain, Humans, Lipoprotein Lipase, Lipoproteins, Neurons, Receptors, LDL, CD36 Antigens, Membrane Microdomains, Low Density Lipoprotein Receptor-Related Protein-1, Mice

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