The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Amino Acid Depletion Therapies: Starving Cancer Cells to Death
Open accessAbstract
Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment response in therapy resistant cancers as well as mitigate treatment-related toxicities by reducing the need for genotoxic agents. To meet their increased demand for biomass accumulation and energy production and to maintain redox homeostasis, tumor cells undergo profound changes in their metabolism. In addition to the diversion of glucose metabolism, this is achieved by upregulation of amino acid metabolism. Interfering with amino acid availability can be selectively lethal to tumor cells and has proven to be a cancer specific Achilles' heel. Here we review the biology behind such cancer specific amino acid dependencies and discuss how these vulnerabilities can be exploited to improve cancer therapies.
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Citations
Cites
From Krebs to clinic: glutamine metabolism to cancer therapy
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Cysteine depletion induces pancreatic tumor ferroptosis in mice
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“T cells upregulate their oxidative metabolism resulting in long-lived and highly activated T cells, whereas tumor cells fail to do so and eventually die [51].”
BackgroundPhosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Locasale, J. W., Grassian, A. R., Melman, T., Lyssiotis, C. A., Mattaini, K. R., Bass, A. J., Heffron, G., Metallo, C. M., Muranen, T., Sharfi, H., et al. (2011) · Nature Genetics · doi:10.1038/ng.890 · Cited by 1,120
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
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Targeting Metabolism for Cancer Therapy
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Glutaminolysis: A Hallmark of Cancer Metabolism
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The eIF2α kinases: their structures and functions
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Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine
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“Increased Gln synthesis is often due to upregulation of Gln synthetase (GS) [15], whereas enhanced glutaminolysis is caused by increased GLS activity and correlates with poor prognosis in glioblastoma, ovarian cancer, breast cancer, medulloblastoma, and lung cancer [16,17].”
Background
Cited by
Altered metabolism in cancer: insights into energy pathways and therapeutic targets
Tufail, M., Jiang, C.-H., & Li, N. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02119-3 · Cited by 534
Xu, M., Fei, J., Xiao, Z.-X., & Yi, Y. (2026) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025106 · Cited by 2
Metadata
- Authors
- Butler, M., van der Meer, L. T., & van Leeuwen, F. N.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 32
- Issue
- 6
- Pages
- 367-381
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W3142100769
- Cited by
- 268
- References
- 100
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Butler, M., van der Meer, L. T., & van Leeuwen, F. N. (2021). Amino Acid Depletion Therapies: Starving Cancer Cells to Death. Trends in Endocrinology & Metabolism. https://doi.org/10.1016/j.tem.2021.03.003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
