Energy stress and adaptation strategy of tumor cells in different microenvironments: from primary tumors to distant metastases
Open accessAbstract
Since the Warburg effect was first described in the 1920s, tumor energy metabolism has been a central focus of cancer research, emerging as a potential therapeutic target. The tumor microenvironment-including blood vessels, immune cells, stromal components, and other cell types-profoundly influences tumor cell metabolism. Variations in energy supply, oxygen availability, nutrient composition, and the accumulation of metabolic waste across different microenvironments challenge tumor cell survival and progression. In response, tumor cells adapt through flexible regulation and reprogramming of metabolic pathways. Although recent studies have explored metabolic adaptation mechanisms in various tumor microenvironments, the full spectrum from primary tumors to distant metastases remains unexplored. This review summarizes energy stress and adaptation maneuvers in tumor cells across different stages of tumor progression and offers a new perspective for comprehensive research to explore therapeutic strategies targeting tumor metabolism.
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Metabolic reprogramming enables tumor cells to adapt to diverse microenvironmental stresses and sustain uncontrolled proliferation.
“Metabolic reprogramming is now recognized as a hallmark of cancer, enabling tumor cells to adapt to diverse microenvironmental stresses and sustain uncontrolled proliferation (23).”
From Bioinformatics-based identification of glycolysis-related signatures associated with drug resistance and prognosis in lung adenocarcinoma (2026) · cites this paper as [23]
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Cited by
Sorted by citations
Zheng, Q., Liu, Y., Li, T., Zhang, X., Geng, Y., Chen, Z., Zhou, J., Fan, W., Wang, Y., Zhang, L., et al. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1871582
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- Authors
- Xu, M., Fei, J., Xiao, Z.-X., & Yi, Y.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Yi, Yong
- Venue
- Acta Biochimica et Biophysica Sinica
- Published
- 2025-07-04
- Volume
- 58
- Issue
- 2
- Pages
- 201-215
- ISSN
- 1672-9145 (ISSN-L)
- PMC
- PMC12900748
- OpenAlex
- W4411989503
- Cited by
- 2
- References
- 162
- Citations by year
- 2026: 2
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Acta Biochimica et Biophysica Sinica (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (82073248)
- Natural Science Foundation of Sichuan Province (2023NSFSC1859)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- tumor energy metabolism, Warburg effect, tumor microenvironment, metabolic reprogramming, energy stress, tumor progression, metastasis, primary tumor, tumor cell adaptation, metabolic therapy
- MeSH terms
- Adaptation, Physiological, Animals, Energy Metabolism, Humans, Neoplasm Metastasis, Neoplasms, Stress, Physiological, Tumor Microenvironment
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