The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
Regulated cell death in myocardial ischemia–reperfusion injury
Abstract
Myocardial ischemia-reperfusion (I/R) injury most commonly occurs in coronary artery disease when prompt reperfusion is used to salvage the ischemic myocardium. Cardiomyocyte death is a significant component of myocardial I/R injury and its mechanism was previously thought to be limited to apoptosis and necrosis. With the discovery of novel types of cell death, ferroptosis, necroptosis, and pyroptosis have been shown to be involved in myocardial I/R. These new forms of regulated cell death cause cardiomyocyte loss and exacerbate I/R injury by affecting reactive oxygen species (ROS) generation, calcium stress, and inflammatory cascades, subsequently mediating adverse remodeling, cardiac dysfunction, and heart failure. Herein, we review the roles of ferroptosis, necroptosis, and pyroptosis in myocardial I/R and discuss their contribution to pathology.
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4 retracted
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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
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Regulation of Ferroptotic Cancer Cell Death by GPX4
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Cited by
Iron Homeostasis and Ferroptosis in Human Diseases: Mechanisms and Therapeutic Prospects
Ru, Q., Li, Y., Chen, L., Wu, Y., Min, J., & Wang, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01969-z · Cited by 724
Li, C., Ma, Z., Wei, X., Wang, Y., Wu, J., Li, X., Sun, X., Ding, Z., Yang, C., & Zou, Y. (2025) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-024-10577-9 · Cited by 13
Self-citationDong, Q., Wang, Z., Wu, Q., & Du, Y. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118765 · Cited by 4
Metadata
- Authors
- Xiang, Q., Yi, X., Zhu, X.-H., Wei, X., & Jiang, D.-S.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 35
- Issue
- 3
- Pages
- 219-234
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W4388776088
- Cited by
- 448
- References
- 115
- FWCI
- 32.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xiang, Q., Yi, X., Zhu, X.-H., Wei, X., & Jiang, D.-S. (2024). Regulated cell death in myocardial ischemia–reperfusion injury. Trends in Endocrinology & Metabolism. https://doi.org/10.1016/j.tem.2023.10.010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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