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Cited by 126

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

ABCA1: at the nexus of cholesterol, HDL and atherosclerosis

ATTIE, A·2007·Trends in Biochemical Sciences
DOI 10.1016/j.tibs.2007.02.001
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Abstract

Cholesterol is an essential component of eukaryotic membranes. To prevent the toxicity associated with cholesterol overload, cells transport excess cholesterol across the plasma membrane in part through the ABCA1 lipid transporter. The discovery that mutations in ABCA1 are associated with high-density lipoprotein (HDL)-deficiency syndromes led to studies that show ABCA1, through its transport of cholesterol and phospholipid to apolipoprotein acceptors in the bloodstream, is crucial for the formation of HDL particles. In the intestine, ABCA1 transports cholesterol from the epithelial cells to the bloodstream, contributing to approximately one-third of HDL production. In the arterial wall, excess cholesterol in macrophages is associated with atherosclerosis; here, ABCA1 is anti-atherogenic because it enables macrophages to rid themselves of excess cholesterol.

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Crossref · 10.1016/j.tibs.2007.02.001

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Metadata

Authors
ATTIE, A.
Venue
Trends in Biochemical Sciences
Publisher
Elsevier BV
Published
2007-04
Volume
32
Issue
4
Pages
172-179
ISSN
0968-0004
DOI
10.1016/j.tibs.2007.02.001
Cited by
126
References
4
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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