Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake

Moore, Kathryn J.; Freeman, Mason W.

doi:10.1161/01.atv.0000229218.97976.43

Cited by 563Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismPhagocytosis and Immune Regulation

Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake

Moore, Kathryn J., Freeman, Mason W.·2006·Arteriosclerosis Thrombosis and Vascular Biology

DOI 10.1161/01.atv.0000229218.97976.43

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Abstract

Atherosclerotic vascular disease arises as a consequence of the deposition and retention of serum lipoproteins in the artery wall. Macrophages in lesions have been shown to express > or = 6 structurally different scavenger receptors for uptake of modified forms of low-density lipoproteins (LDLs) that promote the cellular accumulation of cholesterol. Because cholesterol-laden macrophage foam cells are the primary component of the fatty streak, the earliest atherosclerotic lesion, lipid uptake by these pathways has long been considered a requisite and initiating event in the pathogenesis of atherosclerosis. Although the removal of proinflammatory modified LDLs from the artery wall via scavenger receptors would seem beneficial, the pathways distal to scavenger receptor uptake that metabolize the modified lipoproteins appear to become overwhelmed, leading to the accumulation of cholesterol-laden macrophages and establishment of a chronic inflammatory setting. These observations have led to the current dogma concerning scavenger receptors, which is that they are proatherogenic molecules. However, recent studies suggest that the effects of scavenger receptors on atherogenesis may be more complex. In addition to modified lipoprotein uptake, these proteins are now known to regulate apoptotic cell clearance, initiate signal transduction, and serve as pattern recognition receptors for pathogens, activities that may contribute both to proinflammatory and anti-inflammatory forces regulating atherogenesis. In this review, we focus on recent advances in our knowledge of scavenger receptor regulation and signal transduction, their roles in sterile inflammation and infection, and the potential impact of these pathways in regulating the balance of lipid accumulation and inflammation in the artery wall.

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Increases in circulating TNF-a, IL-6, IL-2R, and CRP are strong predictors of all-cause mortality risk in longitudinal studies of elderly cohorts.
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Monocyte Fate in Atherosclerosis
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Fetuin-A-Containing Calciprotein Particles Reduce Mineral Stress in the Macrophage
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Mouse Models for Atherosclerosis Research—Which Is My Line?
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The CD36-PPARγ Pathway in Metabolic Disorders
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Platelets Mediate Oxidized Low-Density Lipoprotein–Induced Monocyte Extravasation and Foam Cell Formation
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Naringenin Decreases Progression of Atherosclerosis by Improving Dyslipidemia in High-Fat–Fed Low-Density Lipoprotein Receptor–Null Mice
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Inflammation and the Development of Atherosclerosis
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Apolipoprotein B Is an Innate Barrier against Invasive Staphylococcus aureus Infection
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ABCA1: at the nexus of cholesterol, HDL and atherosclerosis
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Macrophages: An elusive yet emerging therapeutic target of atherosclerosis
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Macrophage Scavenger Receptor Class A
de Winther, M. P. J., van Dijk, K. W., Havekes, L. M., & Hofker, M. H. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.290 · Cited by 248 · see citing works

Authors: Moore, K. J., & Freeman, M. W.
Affiliations: Harvard University (US)
ORCID: Moore, Kathryn J.
Freeman, Mason W.
Venue: Arteriosclerosis Thrombosis and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2006-08
Volume: 26
Issue: 8
Pages: 1702-1711
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000229218.97976.43
OpenAlex: W2093979977
Cited by: 562
References: 94
Citations by year: 2026: 16 · 2025: 20 · 2024: 26 · 2023: 25 · 2022: 32 · 2021: 30 · 2020: 23 · 2019: 27 · 2018: 22 · 2017: 16 · 2016: 26 · 2015: 27 · 2014: 28 · 2013: 36 · 2012: 37
FWCI: 2.60
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: scavenger receptors, atherosclerosis, modified low-density lipoprotein, foam cells, cholesterol accumulation, foam cell formation, lipid uptake, sterile inflammation, pattern recognition receptors, efferocytosis, signal transduction, atherogenesis
MeSH terms: Animals, Humans, Atherosclerosis, Lipid Metabolism, Receptors, Scavenger

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Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake

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