Cited by 367Bacterial Genetics and BiotechnologyDrug Transport and Resistance MechanismsEscherichia coli research studies

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New substrates for TonB-dependent transport: do we only see the ‘tip of the iceberg’?

Schauer, Kristine, Rodionov, Dmitry A., de Reuse, Hilde·2008·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2008.04.012

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Abstract

TonB-dependent transport is a mechanism for active uptake across the outer membrane of Gram-negative bacteria. The system promotes transport of rare nutrients and was thought to be restricted to iron complexes and vitamin B12. Recent experimental evidence of TonB-energized transport of nickel and different carbohydrates, in addition to bioinformatic-based predictions, challenges this notion and reveals that the number and variety of TonB-dependent substrates is underestimated. It is becoming clear that the chemical nature of the substrates, the energetic requirements for transport and the subsequent translocation across the cytoplasmic membrane can differ from those of the well-studied systems for iron complexes and vitamin B12. These findings question the understanding of TonB-dependent uptake and provide insights into the adaptation of bacteria to their environments.

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Authors: Schauer, K., Rodionov, D. A., & de Reuse, H.
Affiliations: Centre National de la Recherche Scientifique (FR)
Russian Academy of Sciences (RU)
ORCID: Schauer, Kristine
Rodionov, Dmitry A.
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2008-07
Volume: 33
Issue: 7
Pages: 330-338
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2008.04.012
OpenAlex: W2130630244
Cited by: 360
References: 70
Citations by year: 2026: 12 · 2025: 20 · 2024: 11 · 2023: 5 · 2022: 25 · 2021: 19 · 2020: 28 · 2019: 20 · 2018: 17 · 2017: 29 · 2016: 28 · 2015: 11 · 2014: 23 · 2013: 30 · 2012: 23
FWCI: 1.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: Deutscher Akademischer Austauschdienst
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Keywords: TonB-dependent transport, Gram-negative bacteria, iron complexes, vitamin B12, nickel uptake, carbohydrate transport, substrate specificity, bacterial adaptation
MeSH terms: Bacterial Proteins, Biological Transport, Membrane Proteins, Models, Biological, Phylogeny, Vitamin B 12

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New substrates for TonB-dependent transport: do we only see the ‘tip of the iceberg’?

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