The DOI matches its Crossref record; 69 of the 70 references it cites were found in a registry or an index.
New substrates for TonB-dependent transport: do we only see the ‘tip of the iceberg’?
Abstract
TonB-dependent transport is a mechanism for active uptake across the outer membrane of Gram-negative bacteria. The system promotes transport of rare nutrients and was thought to be restricted to iron complexes and vitamin B12. Recent experimental evidence of TonB-energized transport of nickel and different carbohydrates, in addition to bioinformatic-based predictions, challenges this notion and reveals that the number and variety of TonB-dependent substrates is underestimated. It is becoming clear that the chemical nature of the substrates, the energetic requirements for transport and the subsequent translocation across the cytoplasmic membrane can differ from those of the well-studied systems for iron complexes and vitamin B12. These findings question the understanding of TonB-dependent uptake and provide insights into the adaptation of bacteria to their environments.
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“OM ferric siderophore receptors are TonB-dependent members of the porin superfamily.Hence, they are called TonB-dependent transporters (14) or ligand-gated porins [LGP (15)], in the latter case because ligand binding activates their TonB-depend ent transport process.”
From Siderophore-mediated iron acquisition by Klebsiella pneumoniae (2024) · cites this paper as [14]
Citations
Cites
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
Siderophore-Based Iron Acquisition and Pathogen Control
Miethke, M., & Marahiel, M. A. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00012-07 · Cited by 1,774
Algae acquire vitamin B12 through a symbiotic relationship with bacteria
Croft, M. T., Lawrence, A. D., Raux-Deery, E., Warren, M. J., & Smith, A. G. (2005) · Nature · doi:10.1038/nature04056 · Cited by 1,536
A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis
Xu, J., Bjursell, M. K., Himrod, J., Deng, S., Carmichael, L. K., Chiang, H. C., Hooper, L. V., & Gordon, J. I. (2003) · Science · doi:10.1126/science.1080029 · Cited by 1,353
Bacterial Iron Sources: From Siderophores to Hemophores
Wandersman, C., & Delepelaire, P. (2004) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123811 · Cited by 1,095
Cascalès, E., Buchanan, S. K., Duché, D., Kleanthous, C., Lloubès, R., Postle, K., Riley, M. A., Slatin, S. L., & Cavard, D. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-06 · Cited by 1,066
Enterobactin: an archetype for microbial iron transport.
Raymond, K. N., Dertz, E. A., & Kim, S. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630018100 · Cited by 933
Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria
Crosa, J. H., & Walsh, C. T. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.223-249.2002 · Cited by 797
[24] Inferring phylogenies from protein sequences by parsimony, distance, and likelihood methods
Felsenstein, J. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)66026-1 · Cited by 605
Structural biology of bacterial iron uptake
Krewulak, K. D., & Vogel, H. J. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.026 · Cited by 579
Cited by
Sorted by citations
Microbial degradation of complex carbohydrates in the gut
Flint, H. J., Scott, K. P., Duncan, S. H., Louis, P., & Forano, E. (2012) · Gut Microbes · doi:10.4161/gmic.19897 · Cited by 2,331
Teeling, H., Fuchs, B. M., Becher, D., Klockow, C., Gardebrecht, A., Bennke, C. M., Kassabgy, M., Huang, S., Mann, A. J., Waldmann, J., et al. (2012) · Science · doi:10.1126/science.1218344 · Cited by 1,405
TonB-dependent transporters: regulation, structure, and function
Noinaj, N., Guillier, M., Barnard, & Buchanan, S. K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134247 · Cited by 989
Community proteogenomics reveals insights into the physiology of phyllosphere bacteria
Delmotte, N., Knief, C., Chaffron, S., Innerebner, G., Roschitzki, B., Schlapbach, R., von Mering, C., & Vorholt, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905240106 · Cited by 911
Complex Glycan Catabolism by the Human Gut Microbiota: The Bacteroidetes Sus-like Paradigm
Martens, E. C., Koropatkin, N. M., Smith, T. J., & Gordon, J. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.022848 · Cited by 657
Metadata
- Authors
- Schauer, K., Rodionov, D. A., & de Reuse, H.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Russian Academy of Sciences (RU)
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 33
- Issue
- 7
- Pages
- 330-338
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2130630244
- Cited by
- 360
- References
- 70
- Citations by year
- 2026: 12 · 2025: 20 · 2024: 11 · 2023: 5 · 2022: 25 · 2021: 19 · 2020: 28 · 2019: 20 · 2018: 17 · 2017: 29 · 2016: 28 · 2015: 11 · 2014: 23 · 2013: 30 · 2012: 23
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutscher Akademischer Austauschdienst
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Keywords
- TonB-dependent transport, Gram-negative bacteria, iron complexes, vitamin B12, nickel uptake, carbohydrate transport, substrate specificity, bacterial adaptation
- MeSH terms
- Bacterial Proteins, Biological Transport, Membrane Proteins, Models, Biological, Phylogeny, Vitamin B 12
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