O-GlcNAc signaling: a metabolic link between diabetes and cancer?

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Items 101–200 of 346

1. Glucose Sensing O-GlcNAcylation Pathway Regulates the Nuclear Bile Acid Receptor Farnesoid X Receptor (FXR)
   Wahiba Berrabah, Pierrette Aumercier, Céline Gheeraert, Hélène Dehondt, Emmanuel Bouchaert, Jérémy Alexandre, Maheul Ploton, Claire Mazuy, Sandrine Caron, Anne Tailleux et al. · 2013 · Hepatology
2. Hexosamine biosynthesis in keratinocytes: roles of GFAT and GNPDA enzymes in the maintenance of UDP-GlcNAc content and hyaluronan synthesis
   Sanna Oikari, Katri M. Makkonen, Ashik Jawahar Deen, Ilari Tyni, Riikka Kärnä, Raija Tammi, Markku Tammi · 2016 · Glycobiology
3. N-Glycan Remodeling on Glucagon Receptor Is an Effector of Nutrient Sensing by the Hexosamine Biosynthesis Pathway
   Anita Johswich, Christine Longuet, Judy Pawling, Anas M. Abdel Rahman, Michael C. Ryczko, Daniel J. Drucker, James W. Dennis · 2014 · Journal of Biological Chemistry
4. Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications
   Cheng Xue Qin, Rochelle Sleaby, Amy J. Davidoff, James R. Bell, Miles J. De Blasio, L.M.D. Delbridge, John C. Chatham, Rebecca Helen Ritchie · 2016 · Pharmacological Research
5. Elevated O-GlcNAcylation enhances pro-inflammatory Th17 function by altering the intracellular lipid microenvironment
   Miranda E. Machacek, Harmony Ivanna Saunders, Zhen Zhang, Ee Phie Tan, Jibiao Li, Tiangang Li, María T. Villar, Antonio Artigues, Todd A. Lydic, Gentry K. Cork et al. · 2019 · Journal of Biological Chemistry
6. Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity
   Virginia L. Johnsen, Darrell D. Belke, Curtis C. Hughey, Dustin S. Hittel, Russell T. Hepple, Lauren G. Koch, Steven L. Britton, Jane Shearer · 2012 · Physiological Genomics
7. The Yeast Forkhead Transcription Factors Fkh1 and Fkh2 Regulate Lifespan and Stress Response Together with the Anaphase-Promoting Complex
   Spike D. L. Postnikoff, Mackenzie E. Malo, Berchman Wong, Troy A. A. Harkness · 2012 · PLoS Genetics
8. Energy Management by Enhanced Glycolysis in G1-phase in Human Colon Cancer Cells In Vitro and In Vivo
   Yan Bao, Kuniaki Mukai, Takako Hishiki, Akiko Kubo, Mitsuyo Ohmura, Yuki Sugiura, Tomomi Matsuura, Yoshiko Nagahata, Noriyo Hayakawa, Takehiro Yamamoto et al. · 2013 · Molecular Cancer Research
9. O-GlcNAcylation is required for B cell homeostasis and antibody responses
   Jung-Lin Wu, Ming-Feng Chiang, Pang‐Hung Hsu, Dong-Yen Tsai, Kuo-Hsuan Hung, Ying-Hsiu Wang, Takashi Angata, Kuo‐I Lin · 2017 · Nature Communications
10. O -GlcNAcylation affects β-catenin and E-cadherin expression, cell motility and tumorigenicity of colorectal cancer
    Shani Ben Harosh-Davidovich, Isam Khalaila · 2018 · Experimental Cell Research
11. Metabolic reprogramming and interventions in angiogenesis
    Yun Liu, Zifang Wu, Yikun Li, Yating Chen, Xuan Zhao, Miaomiao Wu, Yaoyao Xia · 2024 · Journal of Advanced Research
12. Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes
    Paola Moretto, Evgenia G. Karousou, Manuela Viola, Ilaria Caon, Maria Luisa D’Angelo, Giancarlo De Luca, Alberto G. Passi, Davide Vigetti · 2015 · Journal of Diabetes Research
13. The Synthesis and Origin of the Pectic Polysaccharide Rhamnogalacturonan II – Insights from Nucleotide Sugar Formation and Diversity
    Maor Bar‐Peled, Breeanna Rae Urbanowicz, Malcolm A. O’Neill · 2012 · Frontiers in Plant Science
14. Nutrient-driven O-GlcNAc cycling – think globally but act locally
    Katryn R. Harwood, John A. Hanover · 2014 · Journal of Cell Science
15. O-Linked N-Acetylglucosamine (O-GlcNAc) Expression Levels Epigenetically Regulate Colon Cancer Tumorigenesis by Affecting the Cancer Stem Cell Compartment via Modulating Expression of Transcriptional Factor MYBL1
    Hua‐Bei Guo, Bing Zhang, Alison V. Nairn, Tamás Nagy, Kelley W. Moremen, Phillip Buckhaults, Michael Pierce · 2017 · Journal of Biological Chemistry
16. O-GlcNAcylation of SIX1 enhances its stability and promotes Hepatocellular Carcinoma Proliferation
    Yi Chu, Mingzuo Jiang, Nan Wu, Bing Xu, Wenjiao Li, Haiming Liu, Song Su, Yanting Shi, Hao Liu, Xiaoliang Gao et al. · 2020 · Theranostics
17. O-GlcNAcylation of Raptor transduces glucose signals to mTORC1
    Chenchen Xu, Xiaoqing Pan, Dong Wang, Yuanyuan Guan, Wenyu Yang, Xing Chen, Ying Liu · 2023 · Molecular Cell
18. Increased Glycolysis and Higher Lactate Production in Hyperglycemic Myotubes
    Jenny Lund, D. Margriet Ouwens, Marianne Wettergreen, Siril Skaret Bakke, G. Hege Thoresen, Vigdis Aas · 2019 · Cells
19. Tools, tactics and objectives to interrogate cellular roles of O-GlcNAc in disease
    Charlie Fehl, John A. Hanover · 2021 · Nature Chemical Biology
20. O-GlcNAcylation and oxidation of proteins: is signalling in the cardiovascular system becoming sweeter?
    Victor V. Lima, Kathryn M. Spitler, Hyehun Choi, Robert Clinton Webb, Rita C. Tostes · 2012 · Clinical Science
21. N-Linked Glycosylation Supports Cross-Talk between Receptor Tyrosine Kinases and Androgen Receptor
    Harri M. Itkonen, Ian Geoffrey Mills · 2013 · PLoS ONE
22. Stable Isotope-Resolved Metabolomics Shows Metabolic Resistance to Anti-Cancer Selenite in 3D Spheroids versus 2D Cell Cultures
    Teresa W.‐M. Fan, Salim S. El‐Amouri, Jéssica K. A. Macêdo, Qing Jun Wang, Huan Song, Teresa Cassel, Andrew N. Lane · 2018 · Metabolites
23. Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View
    Yong Suk Cho, Jin Jiang · 2021 · Frontiers in Cell and Developmental Biology
24. Increased O-GlcNAcylation of NF-κB Enhances Retinal Ganglion Cell Death in Streptozotocin-induced Diabetic Retinopathy
    Seong-Jae Kim, Woong-Sun Yoo, Mee-Young Choi, In Young Chung, Ji-Myong Yoo, Wan-Sung Choi · 2015 · Current Eye Research
25. Novel roles for GlcNAc in cell signaling
    Shamoon Naseem, Salvatore M. Parrino, Dane M. Buenten, James B. Konopka · 2012 · Communicative & Integrative Biology
26. Characterizing Post-Translational Modifications and Their Effects on Protein Conformation Using NMR Spectroscopy
    Ajith Kumar, Vaishali Narayanan, Ashok Sekhar · 2019 · Biochemistry
27. Defining the Progression of Diabetic Cardiomyopathy in a Mouse Model of Type 1 Diabetes
    Miles J. De Blasio, Nguyen Huynh, Minh Deo, Leslie E. Dubrana, Jesse L. Walsh, Andrew M. Willis, Darnel Prakoso, Helen Kiriazis, Daniel G. Donner, John C. Chatham et al. · 2020 · Frontiers in Physiology
28. O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors
    Elena V. Efimova, Oliver K. Appelbe, Natalia Ricco, Steve S.-Y. Lee, Yue Liu, Donald J. Wolfgeher, Tamica N. Collins, Amy C. Flor, Aishwarya Ramamurthy, Sara E. Warrington et al. · 2019 · Molecular Cancer Research
29. Hyperglycemia and aberrant O-GlcNAcylation: contributions to tumor progression
    Andréia Vasconcelos-dos-Santos, Rafaela Muniz de Queiroz, Bruno da Costa Rodrigues, Adriane Regina Todeschini, Wagner B. Dias · 2018 · Journal of Bioenergetics and Biomembranes
30. Amino Acids Attenuate Insulin Action on Gluconeogenesis and Promote Fatty Acid Biosynthesis via mTORC1 Signaling Pathway in trout Hepatocytes
    Weiwei Dai, Stéphane Panserat, Elisabeth Plagnes‐Juan, Iban Seiliez, Sandrine Cassy · 2015 · Cellular Physiology and Biochemistry
31. E2F1 Transcription Factor Regulates O-linked N-acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Expression
    Senthilkumar Muthusamy, Kyung U. Hong, Sujith Dassanayaka, Tariq Hamid, Steven Paul Jones · 2015 · Journal of Biological Chemistry
32. Exploring LeukocyteO-GlcNAcylation as a Novel Diagnostic Tool for the Earlier Detection of Type 2 Diabetes Mellitus
    Clare Springhorn, Tandi Edith Matsha, Rajiv Timothy Erasmus, M. Faadiel Essop · 2012 · The Journal of Clinical Endocrinology & Metabolism
33. The sweet side of the cell cycle
    Ee Phie Tan, Francesca E. Duncan, Chad M Slawson · 2017 · Biochemical Society Transactions
34. Intracellular Protein O-GlcNAc Modification Integrates Nutrient Status with Transcriptional and Metabolic Regulation
    Alexis K. Nagel, Lauren Elizabeth Ball · 2015 · Advances in cancer research
35. Molecular and biochemical regulation of skeletal muscle metabolism
    Morgan D. Zumbaugh, Sally Johnson, Tim H Shi, David Edwin Gerrard · 2022 · Journal of Animal Science
36. Single-Cell Mass Spectrometry of Subpopulations Selected by Fluorescence Microscopy
    Linwen Zhang, Christopher J. Sevinsky, Brian M. Davis, Ákos Vértes · 2018 · Analytical Chemistry
37. Hyphal growth in Candida albicans does not require induction of hyphal-specific gene expression
    Shamoon Naseem, Esteban Araya, J. Konopka · 2015 · Molecular Biology of the Cell
38. Discovery and Confirmation of O-GlcNAcylated Proteins in Rat Liver Mitochondria by Combination of Mass Spectrometry and Immunological Methods
    Weiqian Cao, Jing Cao, Jiangming Huang, Jun Hu Yao, Guoquan Yan, Haoqi Xu, Pengyuan Yang · 2013 · PLoS ONE
39. mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation
    Joseph Gennaro Moloughney, Nicole M. Vega-Cotto, Sharon Liu, Chadni Patel, Peter Kijun Kim, Chang‐Chih Wu, Danielle Albaciete, Cedric Magaway, Austin B. Chang, Swati Rajput et al. · 2018 · Journal of Biological Chemistry
40. The regulatory roles ofO-GlcNAcylation in mitochondrial homeostasis and metabolic syndrome
    Lin Zhao, Zhihui Feng, Xiaoyong Yang, Jiankang Liu · 2016 · Free Radical Research
41. N -Acetylglucosamine Metabolism Promotes Survival of Candida albicans in the Phagosome
    Elisa M. Vesely, Robert B. Williams, James B. Konopka, Michael C. Lorenz · 2017 · mSphere
42. Rice Bran Derived Bioactive Compounds Modulate Risk Factors of Cardiovascular Disease and Type 2 Diabetes Mellitus: An Updated Review
    Nancy Saji, Nidhish Francis, Lachlan J. Schwarz, CHRISTOPHER L. BLANCHARD, Abishek Bommannan Santhakumar · 2019 · Nutrients
43. O-GlcNAcylation and Its Role in Cancer-Associated Inflammation
    Muzi Ouyang, Changmeng Yu, Xiaolian Deng, Yingyi Zhang, Xudong Zhang, Fangfang Duan · 2022 · Frontiers in Immunology
44. Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation
    Donghyun Kang, Jeeyeon Lee, Geunho Yook, Sehan Jeong, Jungkwon Shin, Mi-Sung Kim, Yi‐Jun Kim, Hyeryeon Jung, Jinsung Ahn, Tae‐Woo Kim et al. · 2025 · Nature Communications
45. Physiological regulation of the heat shock response by glutamine: implications for chronic low-grade inflammatory diseases in age-related conditions
    Jaqueline Santos Moreira Leite, Vínicius Fernandes Cruzat, Maurício da Silva Krause, Paulo Ivo Homem de Bittencourt · 2016 · Nutrire
46. 2-Deoxy- d -glucose increases GFAT1 phosphorylation resulting in endoplasmic reticulum-related apoptosis via disruption of protein N -glycosylation in pancreatic cancer cells
    Kousuke Ishino, Mitsuhiro Kudo, Wei‐Xia Peng, Shoko Kure, Kiyoko Kawahara, Kiyoshi Teduka, Yoko Kawamoto, T Kitamura, Takenori Fujii, Tetsushi Yamamoto et al. · 2018 · Biochemical and Biophysical Research Communications
47. EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association
    Yang Wang, Hengyao Shu, Jia Liu, Xin Jin, Lihua Wang, Yanzhao Qu, Mingjie Xia, Pinghui Peng, Yunpeng Feng, Min Wei · 2022 · Journal of Biological Chemistry
48. E2f1 deletion attenuates infarct-induced ventricular remodeling without affecting O-GlcNAcylation
    Sujith Dassanayaka, Kenneth R. Brittian, Andrea Jurkovic, Lauren A. Higgins, Timothy N. Audam, Bethany W. Long, Linda T. Harrison, Giuseppe Militello, Daniel W. Riggs, Mitali G. Chitre et al. · 2019 · Basic Research in Cardiology
49. Inhibition of the hexosamine biosynthesis pathway potentiates cisplatin cytotoxicity by decreasing BiP expression in non–small‐cell lung cancer cells
    Wenshu Chen, C. Kieu, Bryanna Saxton, Shuguang Leng, Piotr Teodor Filipczak, Mathewos Tessema, Steven A. Belinsky, Yong Lin · 2019 · Molecular Carcinogenesis
50. OGT as potential novel target: Structure, function and inhibitors
    Ning Zhang, Hongli Jiang, Kexin Zhang, Jiaxin Zhu, Zhongzhong Wang, Yiteng Long, Yanjun He, Feng Feng, Wenyuan Liu, Feng Ye et al. · 2022 · Chemico-Biological Interactions
51. O-GlcNAcylation and neuronal energy status: Implications for Alzheimer’s disease
    Tiffany S. Pinho, Diogo Vila Verde, Sónia C. Correia, Susana Cardoso, Paula Isabel Moreira · 2018 · Ageing Research Reviews
52. Global profiling of O-GlcNAcylated and/or phosphorylated proteins in hepatoblastoma
    Hang Song, Ji Ma, Zhixuan Bian, Shuhua Chen, Jiabei Zhu, Jing Wang, Nan Jing Huang, Minzhi Yin, Fenyong Sun, Min Xu et al. · 2019 · Signal Transduction and Targeted Therapy
53. O-GlcNAc modification mediates aquaporin 3 to coordinate endometrial cell glycolysis and affects embryo implantation
    Hongshuo Zhang, Jia Qi, Jingyuan Pei, Man Zhang, Yuhong Shang, Zhen Li, Yufei Wang, Jinqiu Guo, Kai-qi Sun, Jianhui Fan et al. · 2021 · Journal of Advanced Research
54. Global identification of O‐GlcNAc transferase (OGT) interactors by a human proteome microarray and the construction of an OGT interactome
    Rui‐Ping Deng, Xianghuo He, Shu-Juan Guo, Wei‐Feng Liu, Yong Tao, Sheng‐ce Tao · 2014 · PROTEOMICS
55. Serum untargeted metabolomics analysis of the mechanisms of evodiamine on type 2 diabetes mellitus model rats
    Yuejie Yu, Qinyan Lu, Feng Chen, Shangli Wang, Chunxiang Niu, Jiabao Liao, Hongwu Wang, Fengjuan Chen · 2022 · Food & Function
56. O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT
    Guo‐Qing Zhu, Mingping Qian, Liesheng Lu, Yan Chen, Xiao Zhang, Qi Wu, Ya Liu, Zhixuan Bian, Yueyue Yang, Susu Guo et al. · 2019 · Carcinogenesis
57. Undetectable histone O-GlcNAcylation in mammalian cells
    Jessica K. Gagnon, Salima Daou, Natalia Zamorano Cuervo, Nicholas Iannantuono, Ian Hammond-Martel, Nazar Mashtalir, Éric Bonneil, Hugo Würtele, Pierre Thibault, El Bachir Affar · 2015 · Epigenetics
58. O-GlcNAc cycling in the developing, adult and geriatric brain
    Olof Lagerlöf · 2018 · Journal of Bioenergetics and Biomembranes
59. O-GlcNAc modification affects the ATM-mediated DNA damage response
    Yuri Miura, Yoko Sakurai, Tamao Endo · 2012 · Biochimica et Biophysica Acta (BBA) - General Subjects
60. Mass Isotopomer Analysis of Metabolically Labeled Nucleotide Sugars and N- and O-Glycans for Tracing Nucleotide Sugar Metabolisms
    Kazuki Nakajima, Emi Ito, Kazuaki Ohtsubo, Ken Shirato, Rina Takamiya, Shinobu Kitazume, Takashi Angata, Naoyuki Taniguchi · 2013 · Molecular & Cellular Proteomics
61. Brain O-GlcNAcylation: Bridging physiological functions, disease mechanisms, and therapeutic applications
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62. An integrative theory for cancer (Review)
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63. Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis
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64. High-glucose environment induced intracellular O-GlcNAc glycosylation and reduced galectin-7 expression in keratinocytes: Implications on impaired diabetic wound healing
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65. Stress response and adaptation: A new molecular toolkit for the 21st century
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66. Reciprocal Regulation Between O-GlcNAcylation and β-Catenin Facilitates Cell Viability and Inhibits Apoptosis in Liver Cancer
    Sicheng Gao, Yun Miao, Yijie Liu, Xing Liu, Xingliang Fan, Yan Lin, Pingan Qian, Jun Zhou, Yaoyao Dai, Xia Li et al. · 2019 · DNA and Cell Biology
67. Regulation of pancreatic cancer TRAIL resistance by protein O-GlcNAcylation
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68. Control of STIM and Orai function by post-translational modifications
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69. The potential role of O-GlcNAc modification in cancer epigenetics
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70. Overview of key molecular and pharmacological targets for diabetes and associated diseases
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71. O-GlcNAcylation of co-activator-associated arginine methyltransferase 1 regulates its protein substrate specificity
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72. Glycation vs. glycosylation: a tale of two different chemistries and biology in Alzheimer’s disease
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73. O-GlcNAc Transferase Regulates Angiogenesis in Idiopathic Pulmonary Arterial Hypertension
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74. AANL (Agrocybe aegerita lectin 2) is a new facile tool to probe for O-GlcNAcylation
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75. Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway
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76. The role of intracellular protein O-glycosylation in cell adhesion and disease
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77. NF-κB signaling is the major inflammatory pathway for inducing insulin resistance
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78. O-GlcNAcylation at promoters, nutrient sensors, and transcriptional regulation
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79. A Glycotherapeutic Approach to Functionalize Biomaterials‐Based Systems
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80. O-GlcNAc / Akt pathway regulates glucose metabolism and reduces apoptosis in liver of piglets with acute cold stress
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81. Silibinin Ameliorates O-GlcNAcylation and Inflammation in a Mouse Model of Nonalcoholic Steatohepatitis
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82. Elevated glucose levels impair the WNT/β-catenin pathway via the activation of the hexosamine biosynthesis pathway in endometrial cancer
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83. Augmented O‐Glc NA cylation of AMP ‐activated kinase promotes the proliferation of LoVo cells, a colon cancer cell line
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84. Metabolic switching in the hypoglycemic and antitumor effects of metformin on high glucose induced HepG2 cells
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85. Spatiotemporal Proximity Labeling Tools to Track GlcNAc Sugar-Modified Functional Protein Hubs during Cellular Signaling
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86. Increasing O-GlcNAcylation Level on Organ Culture of Soleus Modulates the Calcium Activation Parameters of Muscle Fibers
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87. Functional Implications of O-GlcNAcylation-dependent Phosphorylation at a Proximal Site on Keratin 18
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88. Reciprocal regulation between O-GlcNAcylation and tribbles pseudokinase 2 (TRIB2) maintains transformative phenotypes in liver cancer cells
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89. Hyperglycemia-driven signaling bridges between diabetes and cancer
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90. Expression and Bioinformatics-Based Functional Analysis of UAP1 in Lung Adenocarcinoma
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91. An O-GlcNAc transferase pathogenic variant linked to intellectual disability affects pluripotent stem cell self-renewal
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92. A Putative Polypeptide N-Acetylgalactosaminyltransferase/Williams-Beuren Syndrome Chromosome Region 17 (WBSCR17) Regulates Lamellipodium Formation and Macropinocytosis
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93. Direct Monitoring of Protein O-GlcNAcylation by High-Resolution Native Mass Spectrometry
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94. O ‐GlcNAcylation regulates endoplasmic reticulum exit sites through Sec31A modification in conventional secretory pathway
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95. In vitrobiocompatibility and antimicrobial activity of chitin monomer obtain from hollow fiber membrane
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96. Genetically Encoded Green Fluorescent Biosensors for Monitoring UDP-GlcNAc in Live Cells
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97. Peptide microarray analysis of the cross‐talk between O‐Glc NA cylation and tyrosine phosphorylation
    Jie Shi, Tihomir Tomašič, Suhela Sharif, Arwin J. Brouwer, Marko Anderluh, Rob Ruijtenbeek, Roland J. Pieters · 2017 · FEBS Letters
98. O-linked N-acetylglucosamine transferase enhances secretory clusterin expression via liver X receptors and sterol response element binding protein regulation in cervical cancer
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99. Inhibition of O -GlcNAc transferase (OGT) by peptidic hybrids
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100. High glucose stimulates proliferative capacity of liver cancer cells possibly via O ‐GlcNAcylation‐dependent transcriptional regulation of GJC1
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