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The APOBEC Protein Family: United by Structure, Divergent in Function

Salter, Jason D., Bennett, Ryan P., Smith, Harold C.·2016·Trends in Biochemical Sciences

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  • APOBEC proteins play an important role in immune responses against DNA and RNA viral pathogens.

    “Since APOBEC proteins play an important role in immune responses against DNA and RNA viral pathogens (Refs.19–22 and references therein), we also investigated the possible effects of the three APOBECs on SARS-CoV-2 replication and progeny production in our experimental system (Fig. 5A).”
  • The APOBEC proteins are a family of cytosine deaminases that can deaminate cytosine to uracil (C-to-U) in single-stranded nucleic acids and function in innate and adaptive immune responses to viral pathogens.

    “The APOBEC proteins are a family of cytosine deaminases that can deaminate cytosine to uracil (C-to-U) in single-stranded nucleic acids and function in a variety of biological processes, including innate and adaptive immune responses to viral pathogens (Refs.19–22 and references therein).”
  • The pro-viral effect of A3A contrasts with the known anti-viral effect of APOBECs.

    “These pro-viral effect of A3A contrast to the known anti-viral effect of APOBECs19–22.”

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Metadata

Authors
Salter, J. D., Bennett, R. P., & Smith, H. C.
Venue
Trends in Biochemical Sciences
Publisher
Elsevier BV
Published
2016-07
Volume
41
Issue
7
Pages
578-594
ISSN
0968-0004
Cited by
408
References
1
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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