The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Macromolecular Crowding In Vitro , In Vivo , and In Between
Open accessAbstract
Biochemical processes take place in heterogeneous and highly volume occupied or crowded environments that can considerably influence the reactivity and distribution of participating macromolecules. Here we summarize the thermodynamic consequences of excluded volume and longer-ranged nonspecific intermolecular interactions for macromolecular reactions in volume-occupied media. In addition, we summarize and compare the information content of studies of crowding in vitro and in vivo. We emphasize the importance of characterizing the behavior not only of labeled tracer macromolecules, but also the composition and behavior of unlabeled macromolecules in the immediate vicinity of the tracer. Finally, we propose strategies for extending quantitative analyses of crowding in simple model systems to increasingly complex media up to and including intact cells.
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Cites
Some Topics in the Theory of Fluids
Widom, B. (1963) · The Journal of Chemical Physics · doi:10.1063/1.1734110 · Cited by 3,035
On Interaction between Two Bodies Immersed in a Solution of Macromolecules
Asakura, S., & Oosawa, F. (1954) · The Journal of Chemical Physics · doi:10.1063/1.1740347 · Cited by 2,914
Macromolecular crowding: obvious but underappreciated
Ellis, R. J. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01938-7 · Cited by 2,309
Zhou, H.-X., Rivas, G., & Minton, A. P. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125817 · Cited by 2,149
Self-citationInteraction between particles suspended in solutions of macromolecules
Asakura, S., & Oosawa, F. (1958) · Journal of Polymer Science · doi:10.1002/pol.1958.1203312618 · Cited by 2,015
Macromolecular Crowding: Biochemical, Biophysical, and Physiological Consequences
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Self-citationMinton, A. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100005200 · Cited by 1,474
Self-citationZimmerman, S. B., & Trach, S. O. (1991) · Journal of Molecular Biology · doi:10.1016/0022-2836(91)90499-v · Cited by 1,337
Converging concepts of protein folding in vitro and in vivo
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Cited by
All Wired Up: An Exploration of the Electrical Properties of Microtubules and Tubulin
Kalra, A. P., Eakins, B. B., Patel, S. D., Ciniero, G., Rezania, V., Shankar, K., & Tuszynski, J. A. (2020) · ACS Nano · doi:10.1021/acsnano.0c06945 · Cited by 49
(2024) · doi:10.1002/sstr.202400086 · Cited by 4
Metadata
- Authors
- Rivas, G., & Minton, A. P.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 41
- Issue
- 11
- Pages
- 970-981
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2523214233
- Cited by
- 470
- References
- 95
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- green
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