All Wired Up: An Exploration of the Electrical Properties of Microtubules and Tubulin
Abstract
Microtubules are hollow, cylindrical polymers of the protein α, β tubulin, that interact mechanochemically with a variety of macromolecules. Due to their mechanically robust nature, microtubules have gained attention as tracks for precisely directed transport of nanomaterials within lab-on-a-chip devices. Primarily due to the unusually negative tail-like C-termini of tubulin, recent work demonstrates that these biopolymers are also involved in a broad spectrum of intracellular electrical signaling. Microtubules and their electrostatic properties are discussed in this Review, followed by an evaluation of how these biopolymers respond mechanically to electrical stimuli, through microtubule migration, electrorotation and C-termini conformation changes. Literature focusing on how microtubules act as nanowires capable of intracellular ionic transport, charge storage, and ionic signal amplification is reviewed, illustrating how these biopolymers attenuate ionic movement in response to electrical stimuli. The Review ends with a discussion on the important questions, challenges, and future opportunities for intracellular microtubule-based electrical signaling.
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Biochemically tuned electronic energy migration would allow microtubule architectures to be used as targets for photobiomodulation and to transduce photonic energy in biohybrid devices.
“Biochemically tuned electronic energy migration would allow microtubule architectures to be used as targets for photobiomodulation9,63 and to transduce photonic energy in biohybrid devices.64”
From Electronic energy migration in microtubules (2023) · cites this paper as [9]
Cites
Memristor—The Missing Circuit Element
Chua, L. (1971) · IEEE Transactions on Circuit Theory · doi:10.1109/tct.1971.1083337 · Cited by 10,268 · see citing works
Electrostatics of nanosystems: Application to microtubules and the ribosome
Baker, N., Sept, D., Joseph, S., Holst, M., & McCammon, J. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181342398 · Cited by 7,125 · see citing works
Microtubules as a target for anticancer drugs
Jordan, M. A., & Wilson, L. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1317 · Cited by 4,534 · see citing works
Nanoscale Memristor Device as Synapse in Neuromorphic Systems
Jo, S. H., Chang, T., Ebong, I., Bhadviya, B. B., Mazumder, P., & Lu, W. (2010) · Nano Letters · doi:10.1021/nl904092h · Cited by 4,174 · see citing works
Promotion of microtubule assembly in vitro by taxol
SCHIFF, P. B., FANT, J., & HORWITZ, S. B. (1979) · Nature · doi:10.1038/277665a0 · Cited by 3,600 · see citing works
PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations
Dolinsky, T. J., Nielsen, J. E., McCammon, J. A., & Baker, N. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh381 · Cited by 3,485 · see citing works
Dynamic instability of microtubule growth
Mitchison, T., & Kirschner, M. (1984) · Nature · doi:10.1038/312237a0 · Cited by 3,337 · see citing works
Pearlman, D. A., Case, D. A., Caldwell, J. W., Ross, W. S., Cheatham, T. E., DeBolt, S., Ferguson, D. M., Seibel, G., & Kollman, P. A. (1995) · Computer Physics Communications · doi:10.1016/0010-4655(95)00041-d · Cited by 3,129 · see citing works
Limiting Laws and Counterion Condensation in Polyelectrolyte Solutions I. Colligative Properties
Manning, G. S. (1969) · The Journal of Chemical Physics · doi:10.1063/1.1672157 · Cited by 3,088 · see citing works
Mechanics of Motor Proteins and the Cytoskeleton
Howard, & Clark (2002) · Applied Mechanics Reviews · doi:10.1115/1.1451234 · Cited by 2,909 · see citing works
The Molecular Motor Toolbox for Intracellular Transport
Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982 · see citing works
‘Memristive’ switches enable ‘stateful’ logic operations via material implication
Borghetti, J., Snider, G. S., Kuekes, P. J., Yang, J. J., Stewart, D. R., & Williams, R. S. (2010) · Nature · doi:10.1038/nature08940 · Cited by 1,929 · see citing works
Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape
Gittes, F., Mickey, B., Nettleton, J., & Howard, J. (1993) · Journal of Cell Biology · doi:10.1083/jcb.120.4.923 · Cited by 1,788 · see citing works
The Way Things Move: Looking Under the Hood of Molecular Motor Proteins
Vale, R. D., & Milligan, R. A. (2000) · Science · doi:10.1126/science.288.5463.88 · Cited by 1,503 · see citing works
Dielectric constants of heterogeneous mixtures
Looyenga, H. (1965) · Physica · doi:10.1016/0031-8914(65)90045-5 · Cited by 1,267 · see citing works
Microtubule Formation in vitro in Solutions Containing Low Calcium Concentrations
Weisenberg, R. C. (1972) · Science · doi:10.1126/science.177.4054.1104 · Cited by 1,216 · see citing works
Colchicine-binding protein of mammalian brain and its relation to microtubules
Weisenberg, R. C., Broisy, G. G., & Taylor, E. W. (1968) · Biochemistry · doi:10.1021/bi00852a043 · Cited by 1,164 · see citing works
Brain tumour cells interconnect to a functional and resistant network
Osswald, M., Jung, E., Sahm, F., Solecki, G. M., Venkataramani, V., Blaes, J., Heuer, S., Horstmann, H., Wiestler, B., Syed, M., et al. (2015) · Nature · doi:10.1038/nature16071 · Cited by 1,140 · see citing works
Hirokawa, N., Niwa, S., & Tanaka, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.039 · Cited by 1,138 · see citing works
Water Determines the Structure and Dynamics of Proteins
Bellissent‐Funel, M., Hassanali, A. A., Havenith, M., Henchman, R. H., Pohl, P., Sterpone, F., van der Spoel, D., Xu, Y., & Garcı́a, A. E. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00664 · Cited by 951 · see citing works
Ionic channels of excitable membranes
(1985) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(85)90467-0 · Cited by 897 · see citing works
Ellis, R. J., & Minton, A. P. (2003) · Nature · doi:10.1038/425027a · Cited by 894 · see citing works
Self-organization of microtubules and motors
Ndlec, F. J., Surrey, T., Maggs, A. C., & Leibler, S. (1997) · Nature · doi:10.1038/38532 · Cited by 885 · see citing works
Disruption of cancer cell replication by alternating electric fields
Kirson, E. D., Gurvich, Z., Schneiderman, R., Dekel, E., Itzhaki, A., Wasserman, Y., Schatzberger, R., & Palti, Y. (2004) · Cancer research · doi:10.1158/0008-5472.can-04-0083 · Cited by 827 · see citing works
Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubules
Gaskin, F., Cantor, C. R., & Shelanski, M. L. (1974) · Journal of Molecular Biology · doi:10.1016/0022-2836(74)90048-5 · Cited by 821 · see citing works
Microtubule assembly nucleated by isolated centrosomes
Mitchison, T. J., & Kirschner, M. W. (1984) · Nature · doi:10.1038/312232a0 · Cited by 777 · see citing works
An extended dynamical hydration shell around proteins
Ebbinghaus, S., Kim, S. J., Heyden, M., Yu, X., Heugen, U., Gruebele, M., Leitner, D. M., & Havenith, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709207104 · Cited by 706 · see citing works
Axonal transport: cargo-specific mechanisms of motility and regulation
Maday, S., Twelvetrees, A. E., Moughamian, A. J., & Holzbaur, E. L. F. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.019 · Cited by 683 · see citing works
Slaving: Solvent fluctuations dominate protein dynamics and functions
Fenimore, P. W., Frauenfelder, H., McMahon, B. H., & Parak, F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212637899 · Cited by 677 · see citing works
Building the Neuronal Microtubule Cytoskeleton
Kapitein, L. C., & Hoogenraad, C. C. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.046 · Cited by 654 · see citing works
Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
Parri, H. R., Gould, T. M., & Crunelli, V. (2001) · Nature Neuroscience · doi:10.1038/90507 · Cited by 625 · see citing works
An EB1-binding motif acts as a microtubule tip localization signal
Honnappa, S., Gouveia, S. M., Weisbrich, A., Damberger, F. F., Bhavesh, N. S., Jawhari, H., Grigoriev, I., van Rijssel, F. J. A., Buey, R. M., Lawera, A., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.065 · Cited by 611 · see citing works
Excellent Visible-Light Photocatalysis of Fluorinated Polymeric Carbon Nitride Solids
Wang, Y., Di, Y., Antonietti, M., Li, H., Chen, X., & Wang, X. (2010) · Chemistry of Materials · doi:10.1021/cm1019102 · Cited by 596 · see citing works
Assembly dynamics of microtubules at molecular resolution
Kerssemakers, J., Munteanu, E., Laan, L., Noetzel, T., Janson, M., & Dogterom, M. (2006) · Nature · doi:10.1038/nature04928 · Cited by 586 · see citing works
Measurement of the Force-Velocity Relation for Growing Microtubules
Dogterom, M., & Yurke, B. (1997) · Science · doi:10.1126/science.278.5339.856 · Cited by 579 · see citing works
Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study.
Mandelkow�, E., Mandelkow�, E., & Milligan, R. A. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.114.5.977 · Cited by 574 · see citing works
THE MECHANISM OF ACTION OF COLCHICINE
Borisy, G. G., & Taylor, E. W. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.2.535 · Cited by 549 · see citing works
Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells
Wang, X., & Gerdes, H.-H. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2014.211 · Cited by 530 · see citing works
Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)
Theillet, F., Binolfi, A., Frembgen-Kesner, T., Hingorani, K. S., Sarkar, M., Kyne, C., Li, C., Crowley, P. B., Gierasch, L. M., Pielak, G. J., et al. (2014) · Chemical Reviews · doi:10.1021/cr400695p · Cited by 504 · see citing works
Önfelt, B., Nedvetzki, S., Benninger, R. K. P., Purbhoo, M. A., Sowinski, S., Hume, A. N., Seabra, M. C., Neil, M. A. A., French, P. M. W., & Davis, D. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8476 · Cited by 492 · see citing works
Macromolecular Crowding In Vitro , In Vivo , and In Between
Rivas, G., & Minton, A. P. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.08.013 · Cited by 467 · see citing works
The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends
Helenius, J., Brouhard, G., Kalaidzidis, Y., Diez, S., & Howard, J. (2006) · Nature · doi:10.1038/nature04736 · Cited by 454 · see citing works
Borisy, G. G., Marcum, J. M., Olmsted, J. B., Murphy, D. B., & Johnson, K. A. (1975) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1975.tb19196.x · Cited by 424 · see citing works
Near-atomic model of microtubule-tau interactions
Kellogg, E. H., Hejab, N. M. A., Poepsel, S., Downing, K. H., DiMaio, F., & Nogales, E. (2018) · Science · doi:10.1126/science.aat1780 · Cited by 416 · see citing works
Hyman, A. A., Salser, S. J., Drechsel, D. N., Unwin, N., & Mitchison, T. J. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.10.1155 · Cited by 399 · see citing works
Establishing and regulating the composition of cilia for signal transduction
Nachury, M. V., & Mick, D. U. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0116-4 · Cited by 397 · see citing works
Structure of tubulin at 6.5 Å and location of the taxol-binding site
Nogales, E., Wolf, S. G., KHAN, I. A., Ludueña, R. F., & Downing, K. H. (1995) · Nature · doi:10.1038/375424a0 · Cited by 390 · see citing works
How do anti-mitotic drugs kill cancer cells?
Gascoigne, K. E., & Taylor, S. S. (2009) · Journal of Cell Science · doi:10.1242/jcs.039719 · Cited by 375 · see citing works
Real-time observations of microtubule dynamic instability in living cells.
Cassimeris, L., Pryer, N., & Salmon, E. D. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.6.2223 · Cited by 368 · see citing works
Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules.
Trinczek, B., Biernat, J., Baumann, K., Mandelkow, E. M., & Mandelkow, E. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.12.1887 · Cited by 340 · see citing works
Controlling the Direction of Kinesin-Driven Microtubule Movements along Microlithographic Tracks
HIRATSUKA, Y., Tada, T., Oiwa, K., Kanayama, T., & Uyeda, T. Q. P. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)75809-2 · Cited by 336 · see citing works
Light-Controlled Molecular Shuttles Made from Motor Proteins Carrying Cargo on Engineered Surfaces
Hess, H., Clemmens, J., Qin, D., Howard, J., & Viola Vogel, B. (2001) · Nano Letters · doi:10.1021/nl015521e · Cited by 334 · see citing works
Hagen, J. A., Li, W.-J., Steckl, A. J., et al. (2006) · Applied Physics Letters · doi:10.1063/1.2197973 · Cited by 334 · see citing works
Giladi, M., Schneiderman, R. S., Voloshin, T., Porat, Y., Munster, M., Blat, R., Sherbo, S., Bomzon, Z., Urman, N., Itzhaki, A., et al. (2015) · Scientific Reports · doi:10.1038/srep18046 · Cited by 327 · see citing works
ISOLATION OF A PROTEIN SUBUNIT FROM MICROTUBULES
Shelanski, M. L., & Taylor, E. W. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.2.549 · Cited by 323 · see citing works
Fluorescence Imaging with One Nanometer Accuracy: Application to Molecular Motors
Yıldız, A., & Selvin, P. R. (2005) · Accounts of Chemical Research · doi:10.1021/ar040136s · Cited by 322 · see citing works
Intercellular transfer mediated by tunneling nanotubes
Gerdes, H., & Carvalho, R. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.03.005 · Cited by 318 · see citing works
Characterization of microtubule assembly in porcine brain extracts by viscometry
Olmsted, J. B., & Borisy, G. G. (1973) · Biochemistry · doi:10.1021/bi00745a037 · Cited by 317 · see citing works
A Fluorescent Sensor with High Selectivity and Sensitivity for Potassium in Water
He, H., Mortellaro, M. A., Leiner, M. J. P., Fraatz, R. J., & Tusa, J. K. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0284761 · Cited by 315 · see citing works
Mitotic Spindle Assembly and Chromosome Segregation
Kline-Smith, S. L., & Walczak, C. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.012 · Cited by 295 · see citing works
Ionic and nucleotide requirements for microtubule polymerization in vitro
Olmsted, J. B., & Borisy, G. G. (1975) · Biochemistry · doi:10.1021/bi00684a032 · Cited by 293 · see citing works
Margolis, R. L., & Wilson, L. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3466 · Cited by 286 · see citing works
Coordinating Neuronal Actin–Microtubule Dynamics
Coles, C. H., & Bradke, F. (2015) · Current Biology · doi:10.1016/j.cub.2015.06.020 · Cited by 284 · see citing works
Complete amino acid sequence of alpha-tubulin from porcine brain.
Ponstingl, H., Krauhs, E., Little, M., & Kempf, T. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.5.2757 · Cited by 272 · see citing works
Hawkins, T. L., Mirigian, M., Yasar, M. S., & Ross, J. L. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.005 · Cited by 271 · see citing works
Involvement of the carboxyl-terminal domain of tubulin in the regulation of its assembly.
Serrano, L., de la Torre, J., Maccioni, R. B., & Ávila, J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.5989 · Cited by 258 · see citing works
Microtubule Dynamics Reconstituted In Vitro and Imaged by Single-Molecule Fluorescence Microscopy
Gell, C., Bormuth, V., Brouhard, G. J., Cohen, D. N., Diez, S., Friel, C. T., Helenius, J. H., Nitzsche, B., Petzold, H., Ribbe, J., et al. (2010) · Methods in cell biology · doi:10.1016/s0091-679x(10)95013-9 · Cited by 255 · see citing works
The interaction of actin filaments with microtubules and microtubule-associated proteins.
Griffith, L. M., & Pollard, T. D. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34254-6 · Cited by 252 · see citing works
Protein self-diffusion in crowded solutions
Roosen‐Runge, F., Hennig, M., Zhang, F., Jacobs, R. M. J., Sztucki, M., Schober, H., Seydel, T., & Schreiber, F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107287108 · Cited by 247 · see citing works
Molecular Sorting by Electrical Steering of Microtubules in Kinesin-Coated Channels
van den Heuvel, M. G. L., de Graaff, M. P., & Dekker, C. (2006) · Science · doi:10.1126/science.1124258 · Cited by 244 · see citing works
How does taxol stabilize microtubules?
Arnal, I., & Wade, R. H. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00180-1 · Cited by 235 · see citing works
Polarization optical studies of the mitotic spindle
Inou�, S. (1953) · Chromosoma · doi:10.1007/bf01271498 · Cited by 235 · see citing works
A smart dust biosensor powered by kinesin motors
Fischer, T., Agarwal, A., & Hess, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2008.393 · Cited by 234 · see citing works
Erratum: Structure of the αβ tubulin dimer by electron crystallography
Nogales, E., Wolf, S. G., & Downing, K. H. (1998) · Nature · doi:10.1038/30288 · Cited by 227 · see citing works
Molecular shuttles based on motor proteins: active transport in synthetic environments
Hess, H., & Viola Vogel, B. (2001) · Reviews in Molecular Biotechnology · doi:10.1016/s1389-0352(01)00029-0 · Cited by 227 · see citing works
Microtubule-associated proteins control the kinetics of microtubule nucleation
Wieczorek, M., Bechstedt, S., Chaaban, S., & Brouhard, G. J. (2015) · Nature Cell Biology · doi:10.1038/ncb3188 · Cited by 225 · see citing works
Kirson, E. D., Schneiderman, R. S., Dbalý, V., Tovaryš, F., Vymazal, J., Itzhaki, A., Mordechovich, D., Gurvich, Z., Shmueli, E., Goldsher, D., et al. (2009) · BMC Medical Physics · doi:10.1186/1756-6649-9-1 · Cited by 224 · see citing works
Tubulin subunit carboxyl termini determine polymerization efficiency.
Sackett, D. L., Bhattacharyya, B., & Wolff, J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89688-0 · Cited by 219 · see citing works
Rapid Microtubule Self-Assembly Kinetics
Gardner, M. K., Charlebois, B. D., Jánosi, I. M., Howard, J., Hunt, A. J., & Odde, D. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.053 · Cited by 214 · see citing works
EB1 Accelerates Two Conformational Transitions Important for Microtubule Maturation and Dynamics
Maurer, S. P., Cade, N. I., Bohner, G., et al. (2014) · Current Biology · doi:10.1016/j.cub.2013.12.042 · Cited by 210 · see citing works
Tunneling nanotubes, an emerging intercellular communication route in development
Gerdes, H., Rustom, A., & Wang, X. (2012) · Mechanisms of Development · doi:10.1016/j.mod.2012.11.006 · Cited by 209 · see citing works
Dimethyl sulfoxide-induced self-assembly of tubulin lacking associated proteins.
Himes, R. H., Burton, P. R., & Gaito, J. M. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40053-6 · Cited by 208 · see citing works
Physical Interpretation of the Warburg Impedance
Taylor, S. R., & Gileadi, E. (1995) · CORROSION · doi:10.5006/1.3293628 · Cited by 207 · see citing works
Resolving bundled microtubules using anti-tubulin nanobodies
Mikhaylova, M., Cloin, B. M. C., Finan, K., van den Berg, R., Teeuw, J., Kijanka, M. M., Sokołowski, M., Katrukha, E. A., Maidorn, M., Opazo, F., et al. (2015) · Nature Communications · doi:10.1038/ncomms8933 · Cited by 206 · see citing works
Zhai, Y., Kronebusch, P. J., Simon, P. M., & Borisy, G. G. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.1.201 · Cited by 198 · see citing works
Shelden, E. A., & Wadsworth, P. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.4.935 · Cited by 195 · see citing works
Growth, fluctuation and switching at microtubule plus ends
Howard, J., & Hyman, A. A. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2713 · Cited by 195 · see citing works
Tumor treating fields: A new frontier in cancer therapy
Davies, A. M., Weinberg, U., & Palti, Y. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12112 · Cited by 193 · see citing works
Measuring enzyme activities under standardized in vivo ‐like conditions for systems biology
van Eunen, K., Bouwman, J., Daran-Lapujade, P. A. S., Postmus, J., Canelas, A. B., Mensonides, F. I. C., Orij, R., Tüzün, I., van den Brink, J., Smits, G. J., et al. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07524.x · Cited by 178 · see citing works
Higher-order assembly of microtubules by counterions: From hexagonal bundles to living necklaces
Needleman, D. J., Ojeda-López, M. A., Raviv, U., Miller, H. P., Wilson, L., & Safinya, C. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406076101 · Cited by 175 · see citing works
Stretching and Transporting DNA Molecules Using Motor Proteins
Diez, S., Reuther, C., Dinu, C. Z., Seidel, R., Mertig, M., Pompe, W., & Howard, J. (2003) · Nano Letters · doi:10.1021/nl034504h · Cited by 173 · see citing works
The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin
Nawrotek, A., Knossow, M., & Gigant, B. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.07.029 · Cited by 167 · see citing works
Rossini, E., Bochevarov, A. D., & Knapp, E. W. (2018) · ACS Omega · doi:10.1021/acsomega.7b01895 · Cited by 164 · see citing works
Ionic wave propagation along actin filaments
Tuszyński, J. A., Portet, S., Dixon, J. M., Luxford, C., & Cantiello, H. F. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74255-1 · Cited by 163 · see citing works
van Echteld, I., Wechalekar, M. D., Schlesinger, N., Buchbinder, R., & Aletaha, D. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006190.pub2 · Cited by 162 · see citing works
Bachand, G. D., Rivera, S. B., Boal, A. K., et al. (2004) · Nano Letters · doi:10.1021/nl049811h · Cited by 162 · see citing works
Induction of a sheet polymer of tubulin by Zn2+
Larsson, H., Wallin, M., & Edström, Å. (1976) · Experimental Cell Research · doi:10.1016/0014-4827(76)90332-3 · Cited by 161 · see citing works
Dielectric measurement of individual microtubules using the electroorientation method
Minoura, I., & Muto, E. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.071324 · Cited by 156 · see citing works
Parallel computation with molecular-motor-propelled agents in nanofabricated networks
Nicolau, D. V., Lard, M., Korten, T., van Delft, F. C. M. J. M., Persson, M., Bengtsson, E., Månsson, A., Diez, S., Linke, H., & Nicolau, D. V. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510825113 · Cited by 152 · see citing works
A comprehensive macrophage-T-lymphocyte theory of schizophrenia
Smith, R. S. (1992) · Medical Hypotheses · doi:10.1016/0306-9877(92)90117-u · Cited by 151 · see citing works
The role of microtubule movement in bidirectional organelle transport
Kulić, I. M., Brown, A. E., Kim, H., Kural, C., Blehm, B. H., Selvin, P. R., Nelson, P., & Gelfand, V. I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800031105 · Cited by 151 · see citing works
Synthetic Systems Powered by Biological Molecular Motors
Saper, G., & Hess, H. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00249 · Cited by 151 · see citing works
How calcium causes microtubule depolymerization
O’Brien, E. T., Salmon, E. D., & Erickson, H. (1997) · Cell Motility and the Cytoskeleton · doi:10.1002/(sici)1097-0169(1997)36:2 · Cited by 148 · see citing works
Analysis of the migration behaviour of single microtubules in electric fields
Stracke, R., Böhm, K. J., Wollweber, L., Tuszynski, J. A., & Unger, E. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00251-6 · Cited by 147 · see citing works
Self-citationSilver Nanoparticle and Nanowire Formation by Microtubule Templates
Behrens, S. S., Wu, J. L., Habicht, W., et al. (2004) · Chemistry of Materials · doi:10.1021/cm049462s · Cited by 144 · see citing works
Microtubule architecture: inspiration for novel carbon nanotube-based biomimetic materials
Pampaloni, F., & Florin, E. (2008) · Trends in biotechnology · doi:10.1016/j.tibtech.2008.03.002 · Cited by 140 · see citing works
A biopolymer transistor: Electrical amplification by microtubules
Priel, A., Ramos, A. J., Tuszynski, J. A., & Cantiello, H. F. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.078915 · Cited by 138 · see citing works
Electric field generated by axial longitudinal vibration modes of microtubule
Cifra, M., Pokorný, J., Havelka, D., & Kučera, O. (2010) · Biosystems · doi:10.1016/j.biosystems.2010.02.007 · Cited by 137 · see citing works
The effects of methyl mercury binding to microtubules
Vogel, D. G., Margolis, R. L., & Mottet, N. K. (1985) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(85)90392-8 · Cited by 133 · see citing works
Lin, E. C., & Cantiello, H. F. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81188-3 · Cited by 132 · see citing works
Excitation of vibrations in microtubules in living cells
Pokorný, J. (2004) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2003.09.028 · Cited by 128 · see citing works
Zinc ion-induced assembly of tubulin.
Gaskin, F., & Kress, Y. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39936-2 · Cited by 126 · see citing works
Wenger, C., Miranda, P. C., Salvador, R., Thielscher, A., Bomzon, Z., Giladi, M., Mrugala, M. M., & Korshoej, A. R. (2018) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2017.2765282 · Cited by 126 · see citing works
Wang, F., He, L., Dai, W., Xu, Y., Wu, D., Lin, C., Wu, S.-M., Cheng, P., Zhang, Y., Shen, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050638 · Cited by 125 · see citing works
Tuszyński, J. A., Brown, J. A., Crawford, E., Carpenter, E. J., Nip, M. L. A., Dixon, J. M., & Satarić, M. V. (2005) · Mathematical and Computer Modelling · doi:10.1016/j.mcm.2005.05.002 · Cited by 124 · see citing works
Microtubule assembly and disassembly at alkaline pH
Regula, C. S., Pfeiffer, J. R., & Berlin, R. D. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.89.1.45 · Cited by 124 · see citing works
Microscale Transport and Sorting by Kinesin Molecular Motors
Jia, L., Moorjani, S. G., Jackson, T. N., & Hancock, W. O. (2004) · Biomedical Microdevices · doi:10.1023/b:bmmd.0000013368.89455.8d · Cited by 122 · see citing works
Action of drugs on microtubules
Wilson, L. (1975) · Life Sciences · doi:10.1016/0024-3205(75)90476-2 · Cited by 122 · see citing works
Wenger, C., Salvador, R., Basser, P. J., & Miranda, P. C. (2015) · Physics in Medicine and Biology · doi:10.1088/0031-9155/60/18/7339 · Cited by 121 · see citing works
Smilgies, D., & Folta‐Stogniew, E. J. (2015) · Journal of Applied Crystallography · doi:10.1107/s1600576715015551 · Cited by 119 · see citing works
Lin, C., Kao, M., Kurabayashi, K., & Meyhöfer, E. (2008) · Nano Letters · doi:10.1021/nl072742x · Cited by 116 · see citing works
Structural insight into TPX2-stimulated microtubule assembly
Zhang, R., Roostalu, J., Surrey, T., & Nogales, E. (2017) · eLife · doi:10.7554/elife.30959 · Cited by 113 · see citing works
Tubulin bound to colchicine forms polymers different from microtubules.
Andreu, J. M., & Timasheff, S. N. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.22.6753 · Cited by 111 · see citing works
Sahu, S., Ghosh, S. K., Fujita, D., & Bandyopadhyay, A. (2014) · Scientific Reports · doi:10.1038/srep07303 · Cited by 109 · see citing works
Selective adhesion of functional microtubules to patterned silane surfaces
Turner, D. C., Chang, C., Fang, K., Brandow, S. L., & Murphy, D. B. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80151-7 · Cited by 107 · see citing works
Anisotropic Elastic Network Modeling of Entire Microtubules
Deriu, M. A., Soncini, M., Orsi, M., et al. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.06.070 · Cited by 106 · see citing works
Ion Counting from Explicit-Solvent Simulations and 3D-RISM
Giambaşu, G. M., Luchko, T., Herschlag, D., et al. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.01.021 · Cited by 105 · see citing works
Decoupling Ionic and Electronic Currents in Melanin
Sheliakina, M., Mostert, A. B., & Meredith, P. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201805514 · Cited by 105 · see citing works
Stages of tubulin assembly and disassembly studied by time-resolved synchrotron X-ray scattering
Bordas, J., Mandelkow, E., & Mandelkow�, E. (1983) · Journal of Molecular Biology · doi:10.1016/0022-2836(83)90089-x · Cited by 104 · see citing works
Mechanical Properties of a Complete Microtubule Revealed through Molecular Dynamics Simulation
Wells, D. B., & Aksimentiev, A. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.04.038 · Cited by 103 · see citing works
Active Generation and Propagation of Ca2+ Signals within Tunneling Membrane Nanotubes
Smith, I. F., Shuai, J., & Parker, I. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.03.007 · Cited by 102 · see citing works
Nonlinear ionic pulses along microtubules
Sekulic, D. L., Satarić, B. M., Tuszyński, J. A., & Satarić, M. V. (2011) · The European Physical Journal E · doi:10.1140/epje/i2011-11049-0 · Cited by 100 · see citing works
High Rectifying Efficiencies of Microtubule Motility on Kinesin-Coated Gold Nanostructures
van den Heuvel, M. G. L., Butcher, C. T., Smeets, R. M. M., Diez, S., & Dekker, C. (2005) · Nano Letters · doi:10.1021/nl0506554 · Cited by 97 · see citing works
Dimethyl sulfoxide: history, chemistry, and clinical utility in dermatology.
Capriotti, K., & Capriotti, J. A. (2012) · PubMed · Cited by 96 · see citing works
Parallel arrays of microtubles formed in electric and magnetic fields
Vassilev, P. M., Dronzine, R. T., Vassileva, M. P., & Georgiev, G. A. (1982) · Bioscience Reports · doi:10.1007/bf01122171 · Cited by 93 · see citing works
Three-dimensional metallization of microtubules
Kirsch, R., Mertig, M., Pompe, W., et al. (1997) · Thin Solid Films · doi:10.1016/s0040-6090(97)00131-4 · Cited by 92 · see citing works
Relaxation processes due to the electrode-electrolyte interface in ionic solutions
Sanabria, H., & Miller, J. H. (2006) · Physical Review E · doi:10.1103/physreve.74.051505 · Cited by 92 · see citing works
A Piconewton Forcemeter Assembled from Microtubules and Kinesins
Hess, H., Howard, J., & Vogel, V. (2002) · Nano Letters · doi:10.1021/nl025724i · Cited by 91 · see citing works
Mershin, A., Kolomenski, A., Schuessler, H. A., & Nanopoulos, D. V. (2004) · Biosystems · doi:10.1016/j.biosystems.2004.04.003 · Cited by 90 · see citing works
Unidirectional Transport of Kinesin-Coated Beads on Microtubules Oriented in a Microfluidic Device
Yokokawa, R., Takeuchi, S., Kon, T., et al. (2004) · Nano Letters · doi:10.1021/nl048851i · Cited by 89 · see citing works
Interpreting the Conductance Blockades of DNA Translocations through Solid-State Nanopores
Carlsen, A. T., Zahid, O. K., Růžička, J., et al. (2014) · ACS Nano · doi:10.1021/nn501694n · Cited by 89 · see citing works
Krouglova, T., Vercammen, J., & Engelborghs, Y. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.040717 · Cited by 88 · see citing works
Melanin-based electronics: From proton conductors to photovoltaics and beyond
Vahidzadeh, E., Kalra, A. P., & Shankar, K. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.09.026 · Cited by 86 · see citing works
Self-citationMillimeter Scale Alignment of Magnetic Nanoparticle Functionalized Microtubules in Magnetic Fields
Platt, M., Muthukrishnan, G., Hancock, W. O., & Williams, M. E. (2005) · Journal of the American Chemical Society · doi:10.1021/ja055815s · Cited by 84 · see citing works
Tuszynski, J. A., Carpenter, E. J., Huzil, J. T., Malinski, W., Luchko, T., & Luduena, R. F. (2006) · The International Journal of Developmental Biology · doi:10.1387/ijdb.052063jt · Cited by 83 · see citing works
Salim, A. S. (1992) · PubMed · Cited by 82 · see citing works
Burton, P., & Himes, R. (1978) · The Journal of Cell Biology · doi:10.1083/jcb.77.1.120 · Cited by 81 · see citing works
Active Alignment of Microtubules with Electric Fields
Kim, T., Kao, M., Hasselbrink, E. F., & Meyhöfer, E. (2006) · Nano Letters · doi:10.1021/nl061474k · Cited by 80 · see citing works
Wilson, L., Miller, H. P., Farrell, K., Snyder, K. B., Thompson, W. C., & Purich, D. L. (1985) · Biochemistry · doi:10.1021/bi00340a045 · Cited by 79 · see citing works
Directing Transport of CoFe 2 O 4 ‐Functionalized Microtubules with Magnetic Fields
Hutchins, B. M., Platt, M., Hancock, W. O., & Williams, M. E. (2006) · Small · doi:10.1002/smll.200600410 · Cited by 79 · see citing works
A nonlinear model of ionic wave propagation along microtubules
Satarić, M. V., Ilić, D. I., Ralević, N., & Tuszynski, J. A. (2009) · European Biophysics Journal · doi:10.1007/s00249-009-0421-5 · Cited by 78 · see citing works
Tubulin polymerization in dimethyl sulfoxide.
Robinson, J., & Engelborghs, Y. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83785-7 · Cited by 76 · see citing works
Zhai, Y., & Borisy, G. G. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.4.881 · Cited by 76 · see citing works
Dielectric Properties of Binary Solvent Mixtures of Dimethyl Sulfoxide with Water
Yang, L., Yang, X., Huang, K., Jia, G.-Z., & Shang, H. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10031261 · Cited by 76 · see citing works
Lima, L. F., Vieira, A. L., Mukai, H., et al. (2017) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2017.06.069 · Cited by 72 · see citing works
The Frequency Dependent Permittivity and AC Conductivity of Random Electrical Networks
Panteny, S., Stevens, R., & Bowen, C. (2005) · Ferroelectrics · doi:10.1080/00150190590965884 · Cited by 71 · see citing works
An Ultrasensitive Fluorescent Paper-Based CO2 Sensor
Wang, H., Vagin, S. I., Rieger, B., et al. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c03405 · Cited by 70 · see citing works
Tubulin Dimers Oligomerize before Their Incorporation into Microtubules
Mozziconacci, J., Sandblad, L., Wachsmuth, M., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003821 · Cited by 69 · see citing works
Solitonic Ionic Currents Along Microtubules
Satarić, M. V., Sekulic, D. L., & Živanov, M. B. (2010) · Journal of Computational and Theoretical Nanoscience · doi:10.1166/jctn.2010.1609 · Cited by 67 · see citing works
Microtubule Inner Proteins: A Meshwork of Luminal Proteins Stabilizing the Doublet Microtubule
Ichikawa, M., & Bui, K. H. (2018) · BioEssays · doi:10.1002/bies.201700209 · Cited by 67 · see citing works
Design and characterization of protein-quercetin bioactive nanoparticles
Fang, R., Jing, H., Chai, Z., et al. (2011) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-9-19 · Cited by 64 · see citing works
Thompson, G. L., Roth, C. C., Dalzell, D. R., Kuipers, M. A., & Ibey, B. L. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.5.055005 · Cited by 63 · see citing works
Microtubule alignment and manipulation using AC electrokinetics
Uppalapati, M., Huang, Y., Jackson, T. N., & Hancock, W. O. (2008) · Small · doi:10.1002/smll.200701088 · Cited by 62 · see citing works
Electrophoresis of individual microtubules in microchannels
van den Heuvel, M. G. L., de Graaff, M. P., Lemay, S. G., & Dekker, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608316104 · Cited by 62 · see citing works
Possible role of electrodynamic interactions in long-distance biomolecular recognition
Preto, J., Pettini, M., & Tuszyński, J. A. (2015) · Physical Review E · doi:10.1103/physreve.91.052710 · Cited by 62 · see citing works
Bundles of Brain Microtubules Generate Electrical Oscillations
Cantero, M. D. R., Etchegoyen, C. V., Perez, P. L., Scarinci, N., & Cantiello, H. F. (2018) · Scientific Reports · doi:10.1038/s41598-018-30453-2 · Cited by 62 · see citing works
Conformational Analysis of the Carboxy-Terminal Tails of Human β-Tubulin Isotypes
Luchko, T., Huzil, J. T., Stepanova, M., & Tuszyński, J. A. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.115113 · Cited by 61 · see citing works
The effects of dimethyl sulfoxide on the kinetics of tubulin assembly
Algaier, J., & Himes, R. H. (1988) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(88)90078-7 · Cited by 59 · see citing works
Transitions in microtubule C-termini conformations as a possible dendritic signaling phenomenon
Priel, A., Tuszynski, J. A., & Woolf, N. J. (2005) · European Biophysics Journal · doi:10.1007/s00249-005-0003-0 · Cited by 57 · see citing works
Merzlyak, P. G., Capistrano, M.-F. P., Valeva, A., et al. (2005) · Biophysical Journal · doi:10.1529/biophysj.105.066472 · Cited by 57 · see citing works
Proteins are paradigms of stochastic complexity
Fenimore, P. W., Frauenfelder, H., McMahon, B. H., et al. (2005) · Physica A Statistical Mechanics and its Applications · doi:10.1016/j.physa.2004.12.004 · Cited by 56 · see citing works
In vitro microtubule assembly regulation by divalent cations and nucleotides
Gaskin, F. (1981) · Biochemistry · doi:10.1021/bi00508a043 · Cited by 55 · see citing works
Microtubules soften due to cross-sectional flattening
Memet, E., Hilitski, F., MORRIS, M. A., Schwenger, W. J., Dogic, Z., & Mahadevan, L. (2018) · eLife · doi:10.7554/elife.34695 · Cited by 54 · see citing works
Microtubules as Sub-Cellular Memristors
Tuszynski, J., Friesen, D. E., Freedman, H., Sbitnev, V. I., Kim, H., Santelices, I., Kalra, A., Patel, S. D., Shankar, K., & Chua, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-58820-y · Cited by 54 · see citing works
Self-citationElectrical Docking of Microtubules for Kinesin-Driven Motility in Nanostructures
van den Heuvel, M. G. L., Butcher, C. T., Lemay, S. G., Diez, S., & Dekker, C. (2005) · Nano Letters · doi:10.1021/nl048291n · Cited by 53 · see citing works
Carboxy-terminal amino acid sequence of α-tubulin from porcine brain
Ponstingl, H., Little, M., Krauhs, E., et al. (1979) · Nature · doi:10.1038/282423a0 · Cited by 51 · see citing works
Electromagnetic Field of Microtubules: Effects on Transfer of Mass Particles and Electrons
Pokorný, J., Hašek, J., & Jelínek, F. (2005) · Journal of Biological Physics · doi:10.1007/s10867-005-1286-1 · Cited by 51 · see citing works
Duellberg, C., Fourniol, F. J., Maurer, S. P., Roostalu, J., & Surrey, T. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.10.003 · Cited by 50 · see citing works
Microtubule Gliding and Cross-Linked Microtubule Networks on Micropillar Interfaces
Roos, W. H., Ulmer, J., Gräter, S., Surrey, T., & Spatz, J. P. (2005) · Nano Letters · doi:10.1021/nl051865j · Cited by 50 · see citing works
Movement and Alignment of Microtubules in Electric Fields and Electric-Dipole-Moment Estimates
Böhm, K. J., Mavromatos, N. E., Michette, A. G., Stracke, R., & Unger, E. (2005) · Electromagnetic Biology and Medicine · doi:10.1080/15368370500380010 · Cited by 50 · see citing works
Biological wires, communication systems, and implications for disease
Friesen, D. E., Craddock, T. J. A., Kalra, A. P., & Tuszynski, J. A. (2015) · Biosystems · doi:10.1016/j.biosystems.2014.10.006 · Cited by 48 · see citing works
Model of ionic currents through microtubule nanopores and the lumen
Freedman, H., Rezania, V., Priel, A., Carpenter, E. J., Noskov, S. Y., & Tuszyński, J. A. (2010) · Physical Review E · doi:10.1103/physreve.81.051912 · Cited by 46 · see citing works
Self-citationFujimoto, K., Kitamura, M., Yokokawa, M., Kanno, I., Kotera, H., & Yokokawa, R. (2012) · ACS Nano · doi:10.1021/nn3045038 · Cited by 46 · see citing works
Junker, N. O., Vaghefikia, F., Albarghash, A., Höfig, H., Kempe, D., Walter, J., Otten, J., Pohl, M., Katranidis, A., Wiegand, S., et al. (2019) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.9b01239 · Cited by 46 · see citing works
Single-Nanopore Investigations with Ion Conductance Microscopy
Chen, C., Zhou, Y., & Baker, L. A. (2011) · ACS Nano · doi:10.1021/nn203205s · Cited by 45 · see citing works
Molecular dynamics modeling of tubulin C‐terminal tail interactions with the microtubule surface
Freedman, H., Luchko, T., Ludueña, R. F., & Tuszyński, J. A. (2011) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.23155 · Cited by 45 · see citing works
A nonlinear cable-like model of amplified ionic wave propagation along microtubules
Priel, A., & Tuszyński, J. A. (2008) · EPL (Europhysics Letters) · doi:10.1209/0295-5075/83/68004 · Cited by 45 · see citing works
Self-citationMultilayered Semiconductor Membranes for Nanopore Ionic Conductance Modulation
Gracheva, M. E., Melnikov, D. V., & Leburton, J. (2008) · ACS Nano · doi:10.1021/nn8004679 · Cited by 44 · see citing works
A Phytochrome-Derived Photoswitch for Intracellular Transport
Adrian, M., Nijenhuis, W., Hoogstraaten, R. I., et al. (2017) · ACS Synthetic Biology · doi:10.1021/acssynbio.6b00333 · Cited by 44 · see citing works
Small Crowders Slow Down Kinesin-1 Stepping by Hindering Motor Domain Diffusion
Sozański, K., Ruhnow, F., Wiśniewska, A., Tabaka, M., Diez, S., & Hołyst, R. (2015) · Physical Review Letters · doi:10.1103/physrevlett.115.218102 · Cited by 43 · see citing works
Chafai, D. E., Sulimenko, V., Havelka, D., Kubínová, L., Dráber, P., & Cifra, M. (2019) · Advanced Materials · doi:10.1002/adma.201903636 · Cited by 43 · see citing works
Detrich, H. W., & Overton, S. A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67475-7 · Cited by 41 · see citing works
Macromolecular Crowding Pushes Catalyzed Microtubule Growth to Near the Theoretical Limit
Wieczorek, M., Chaaban, S., & Brouhard, G. J. (2013) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-013-0292-9 · Cited by 41 · see citing works
Nanomechanical Model of Microtubule Translocation in the Presence of Electric Fields
Kim, T., Kao, M., Hasselbrink, E. F., & Meyhöfer, E. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.112755 · Cited by 41 · see citing works
The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments
Churchill, C. D. M., Kłobukowski, M., & Tuszyński, J. A. (2014) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12475 · Cited by 40 · see citing works
Santelices, I. B., Friesen, D. E., Bell, C., Hough, C. M., Xiao, J., Kalra, A. P., Kar, P., Freedman, H., Rezania, V., Lewis, J. D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09323-w · Cited by 40 · see citing works
Self-citationControl of molecular shuttles by designing electrical and mechanical properties of microtubules
Isozaki, N., Shintaku, H., Kotera, H., Hawkins, T. L., Ross, J. L., & Yokokawa, R. (2017) · Science Robotics · doi:10.1126/scirobotics.aan4882 · Cited by 39 · see citing works
Nanoblade Delivery and Incorporation of Quantum Dot Conjugates into Tubulin Networks in Live Cells
Xu, J., TeSlaa, T. A., Wu, T., et al. (2012) · Nano Letters · doi:10.1021/nl302821g · Cited by 38 · see citing works
Intermembrane linkage mediated by tubulin
Vassilev, P., Kanazirska, M. P., & Tien, H. T. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)90642-4 · Cited by 38 · see citing works
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Electronic energy migration in microtubules
Kalra, A. P., Benny, A., Travis, S. M., Zizzi, E. A., Morales-Sanchez, A., Oblinsky, D. G., Craddock, T. J. A., Hameroff, S. R., MacIver, M. B., Tuszyński, J. A., et al. (2023) · ACS Central Science · doi:10.1021/acscentsci.2c01114 · Cited by 80 · see citing works
Self-citation
- Authors
- Kalra, A. P., Eakins, B. B., Patel, S. D., Ciniero, G., Rezania, V., Shankar, K., & Tuszynski, J. A.
- Affiliations
- University of Alberta (CA)
- Politecnico di Torino (IT)
- MacEwan University (CA)
- Department of Physics, University of Alberta, 11335 Saskatchewan Dr NW, Edmonton, Alberta T6G 2M9, Canada
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-11-20
- Volume
- 14
- Issue
- 12
- Pages
- 16301-16320
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W3098919661
- Cited by
- 49
- References
- 266
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 8 · 2023: 9 · 2022: 9 · 2021: 5
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novocure
- Government of Canada
- Alberta Innovates
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Electrostatics and Colloid Interactions
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- microtubules, tubulin, electrical properties, electrorotation, C-terminal conformation, nanowires, ion transport, charge storage, electrostatic properties, nanomaterial transport
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