The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
The SLC25 Mitochondrial Carrier Family: Structure and Mechanism
Open accessAbstract
Members of the mitochondrial carrier family (SLC25) provide the transport steps for amino acids, carboxylic acids, fatty acids, cofactors, inorganic ions, and nucleotides across the mitochondrial inner membrane and are crucial for many cellular processes. Here, we use new insights into the transport mechanism of the mitochondrial ADP/ATP carrier to examine the structure and function of other mitochondrial carriers. They all have a single substrate-binding site and two gates, which are present on either side of the membrane and involve salt-bridge networks. Transport is likely to occur by a common mechanism, in which the coordinated movement of six structural elements leads to the alternating opening and closing of the matrix or cytoplasmic side of the carriers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
SWISS-MODEL: homology modelling of protein structures and complexes
Waterhouse, A., Bertoni, M., Bienert, S., Studer, G., Tauriello, G., Gumienny, R., Heer, F. T., de Beer, T. A. P., Rempfer, C., Bordoli, L., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky427 · Cited by 13,067
Simple Allosteric Model for Membrane Pumps
JARDETZKY, O. (1966) · Nature · doi:10.1038/211969a0 · Cited by 1,291
Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
Pebay-Peyroula, E., Dahout-Gonzalez, C., Kahn, R., Trézéguet, V., Lauquin, G. J.-M., & Brandolin, G. (2003) · Nature · doi:10.1038/nature02056 · Cited by 998
Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria
Fedorenko, A., Lishko, P. V., & Kirichok, Y. (2012) · Cell · doi:10.1016/j.cell.2012.09.010 · Cited by 968
The ADP and ATP transport in mitochondria and its carrier
Klingenberg, M. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.04.011 · Cited by 612
Shared Molecular Mechanisms of Membrane Transporters
Drew, D., & Boudker, O. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014520 · Cited by 506
Citrin and aralar1 are Ca2+-stimulated aspartate/glutamate transporters in mitochondria
Palmieri, L., Pardo, B., Lasorsa, F. M., del Arco, A., Kobayashi, K., Iijima, M., Runswick, M. J., Walker, J. E., Saheki, T., Satrústegui, J., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.18.5060 · Cited by 505
Adenine Nucleotide Translocation of Mitochondria: 1. Specificity and Control
Pfaff, E., & Klingenberg, M. (1968) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1968.tb00420.x · Cited by 424
The oxidation of citrate, isocitrate and cis-aconitate by isolated mitochondria
Chappell, J. (1964) · Biochemical Journal · doi:10.1042/bj0900225 · Cited by 394
Aquila, H., Link, T. A., & Klingenberg, M. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03941.x · Cited by 366
Cited by
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
Girardi, E., Agrimi, G., Goldmann, U., Fiume, G., Lindinger, S., Sedlyarov, V., Srndic, I., Gürtl, B., Agerer, B., Kartnig, F., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19871-x · Cited by 123
Carraro, M., Carrer, A., Urbani, A., & Bernardi, P. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.05.014 · Cited by 71
Mitochondrial phosphoproteomes are functionally specialized across tissues
Hansen, F. M., Kremer, L. S., Karayel, O., Bludau, I., Larsson, N.-G., Kühl, I., & Mann, M. (2024) · Life Science Alliance · doi:10.26508/lsa.202302147 · Cited by 29
Bertucci, T., Bowles, K. R., Lotz, S., Bheda, S., Qi, L., Farjood, F., Whitton, K., Goderie, S. K., Borden, S., Rossi, A., et al. (2023) · doi:10.1101/2023.07.11.548571 · Cited by 22
Mavridou, V., King, M. S., Bazzone, A., Springett, R., & Kunji, E. R. S. (2024) · Science Advances · doi:10.1126/sciadv.adp7725 · Cited by 20
Self-citation
Metadata
- Authors
- Ruprecht, J. J., & Kunji, E. R. S.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 45
- Issue
- 3
- Pages
- 244-258
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2990776892
- Cited by
- 394
- References
- 66
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The SLC25 Mitochondrial Carrier Family: Structure and Mechanism. https://app.cochat.ai/papers/10.1016/j.tibs.2019.11.001
- The paper
- Ruprecht, J. J., & Kunji, E. R. S. (2020). The SLC25 Mitochondrial Carrier Family: Structure and Mechanism. Trends in Biochemical Sciences. https://doi.org/10.1016/j.tibs.2019.11.001
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
