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Production of self-assembling biomaterials for tissue engineering

Open access
Kyle, Stuart, Aggeli, Amalia, Ingham, Eileen, McPherson, Michael J.·2009·Trends in Biotechnology

Abstract

Self-assembling peptide-based biomaterials are being developed for use as 3D tissue engineering scaffolds and for therapeutic drug-release applications. Chemical synthesis provides custom-made peptides in small quantities, but production approaches based upon transgenic organisms might be more cost-effective for large-scale peptide production. Long lead times for developing appropriate animal clones or plant lines and potential negative public opinion are obstacles to these routes. Microbes, particularly safe organisms used in the food industry, offer a more rapid route to the large-scale production of recombinant self-assembling biomaterials. In this review, recent advances and challenges in the recombinant production of collagen, elastin and de novo designed self-assembling peptides are discussed.

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Metadata

Authors
Kyle, S., Aggeli, A., Ingham, E., & McPherson, M. J.
Venue
Trends in Biotechnology
Publisher
Elsevier BV
Published
2009-07
Volume
27
Issue
7
Pages
423-433
ISSN
0167-7799 (ISSN-L)
OpenAlex
W2008625423
Cited by
226
References
0
FWCI
0.79
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Production of self-assembling biomaterials for tissue engineering. https://app.cochat.ai/papers/10.1016/j.tibtech.2009.04.002
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Kyle, S., Aggeli, A., Ingham, E., & McPherson, M. J. (2009). Production of self-assembling biomaterials for tissue engineering. Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2009.04.002

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.