MALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives

Formaldehyde fixation.

Fox, C. H., JOHNSON, F. B., Whiting, J., & Pp, R. (1985) · Journal of Histochemistry & Cytochemistry · doi:10.1177/33.8.3894502 · Cited by 1,098 · see citing works

Imaging mass spectrometry

McDonnell, L. A., & Heeren, R. M. A. (2007) · Mass Spectrometry Reviews · doi:10.1002/mas.20124 · Cited by 1,082 · see citing works

Sublimation as a method of matrix application for mass spectrometric imaging

Hankin, J. A., Barkley, R. M., & Murphy, R. C. (2007) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2007.06.010 · Cited by 598 · see citing works

Direct Molecular Analysis of Whole-Body Animal Tissue Sections by Imaging MALDI Mass Spectrometry

Khatib-Shahidi, S., Andersson, M., Herman, J. L., Gillespie, T. A., & Caprioli, R. M. (2006) · Analytical Chemistry · doi:10.1021/ac060788p · Cited by 500 · see citing works

Identification of proteins directly from tissue: in situ tryptic digestions coupled with imaging mass spectrometry

Groseclose, M. R., Andersson, M., Hardesty, W. M., & Caprioli, R. M. (2007) · Journal of Mass Spectrometry · doi:10.1002/jms.1177 · Cited by 377 · see citing works

Direct analysis of drug candidates in tissue by matrix‐assisted laser desorption/ionization mass spectrometry

Reyzer, M. L., Hsieh, Y., Ng, K., Korfmacher, W. A., & Caprioli, R. M. (2003) · Journal of Mass Spectrometry · doi:10.1002/jms.525 · Cited by 368 · see citing works

Integrating Histology and Imaging Mass Spectrometry

Chaurand, P., Schwartz, S. A., Billheimer, D. D., et al. (2004) · Analytical Chemistry · doi:10.1021/ac0351264 · Cited by 366 · see citing works

Automated Acoustic Matrix Deposition for MALDI Sample Preparation

Aerni, H. R., Cornett, D. S., & Caprioli, R. M. (2005) · Analytical Chemistry · doi:10.1021/ac051534r · Cited by 343 · see citing works

High‐throughput proteomic analysis of formalin‐fixed paraffin‐embedded tissue microarrays using MALDI imaging mass spectrometry

Groseclose, M. R., Massion, P. P., Chaurand, P., et al. (2008) · PROTEOMICS · doi:10.1002/pmic.200800495 · Cited by 318 · see citing works

Direct Analysis and MALDI Imaging of Formalin-Fixed, Paraffin-Embedded Tissue Sections

Lemaire, R., Desmons, A., Tabet, J. C., Day, R. W., Salzet, M., & Fournier, I. (2007) · Journal of Proteome Research · doi:10.1021/pr060549i · Cited by 309 · see citing works

Molecular imaging of proteins in tissues by mass spectrometry

Seeley, E. H., & Caprioli, R. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801374105 · Cited by 302 · see citing works

Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections

Seeley, E. H., Oppenheimer, S. R., Mi, D., et al. (2008) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2008.03.016 · Cited by 299 · see citing works

Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections

Stoeckli, M., Staab, D., & Schweitzer, A. (2006) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2006.10.007 · Cited by 298 · see citing works

Classification of HER2 Receptor Status in Breast Cancer Tissues by MALDI Imaging Mass Spectrometry

Rauser, S., Marquardt, C., Balluff, B., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr901008d · Cited by 277 · see citing works

Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction

Andersson, M., Groseclose, M. R., Deutch, A. Y., & Caprioli, R. M. (2007) · Nature Methods · doi:10.1038/nmeth1145 · Cited by 249 · see citing works

Proteomic-Based Prognosis of Brain Tumor Patients Using Direct-Tissue Matrix-Assisted Laser Desorption Ionization Mass Spectrometry

Schwartz, S. A., Weil, R. J., Thompson, R. C., Shyr, Y., Moore, J. H., Toms, S. A., Johnson, M. D., & Caprioli, R. M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3016 · Cited by 236 · see citing works

Tissue ischemia time affects gene and protein expression patterns within minutes following surgical tumor excision

Spruessel, A., Steimann, G., Jung, M., Lee, S. A., Carr, T., Fentz, A., Spangenberg, J., Zornig, C., Juhl, H. H., & David, K. A. (2004) · BioTechniques · doi:10.2144/04366rr04 · Cited by 231 · see citing works

Solvent-free matrix dry-coating for MALDI imaging of phospholipids

Puolitaival, S. M., Burnum-Johnson, K., Cornett, D. S., & Caprioli, R. M. (2008) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2008.02.013 · Cited by 228 · see citing works

Protein Profiling in Brain Tumors Using Mass Spectrometry

Schwartz, S. A., Weil, R. J., Johnson, M. D., Toms, S. A., & Caprioli, R. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0927-3 · Cited by 206 · see citing works

Imaging Mass Spectrometry of a Specific Fragment of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Kinase 2 Discriminates Cancer from Uninvolved Prostate Tissue

Cazares, L. H., Troyer, D. A., Mendrinos, S. E., Lance, R. A., Nyalwidhe, J. O., Beydoun, H. A., Clements, M. A., Drake, R. R., & Semmes, O. J. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2892 · Cited by 194 · see citing works

A Novel Histology-directed Strategy for MALDI-MS Tissue Profiling That Improves Throughput and Cellular Specificity in Human Breast Cancer

Cornett, D. S., Mobley, J. A., Dias, E. C., et al. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600119-mcp200 · Cited by 191 · see citing works

Identification of Markers of Taxane Sensitivity Using Proteomic and Genomic Analyses of Breast Tumors from Patients Receiving Neoadjuvant Paclitaxel and Radiation

Bauer, J. A., Chakravarthy, A. B., Rosenbluth, J. M., Mi, D., Seeley, E. H., Granja-Ingram, N. D. M., Olivares, M. G., Kelley, M. C., Mayer, I. A., Meszoely, I. M., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1091 · Cited by 186 · see citing works

Heat-induced antigen retrieval: Mechanisms and application to histochemistry

Yamashita, S. (2006) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2006.09.001 · Cited by 177 · see citing works

Identifying prostate carcinoma by MALDI-Imaging

Schwamborn, K., Krieg, R. C., Reska, M., et al. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.20.2.155 · Cited by 168 · see citing works

Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging

Sinha, T. K., Khatib-Shahidi, S., Yankeelov, T. E., Mapara, K., Ehtesham, M., Cornett, D. S., Dawant, B. M., Caprioli, R. M., & Gore, J. C. (2008) · Nature Methods · doi:10.1038/nmeth1147 · Cited by 168 · see citing works

Molecular Analysis of Tumor Margins by MALDI Mass Spectrometry in Renal Carcinoma

Oppenheimer, S. R., Mi, D., Sanders, M. E., & Caprioli, R. M. (2010) · Journal of Proteome Research · doi:10.1021/pr900936z · Cited by 167 · see citing works

Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation

Burnum-Johnson, K., Cornett, D. S., Puolitaival, S. M., Milne, S. B., Myers, D. S., Tranguch, S. L., Brown, H. A., Dey, S. K., & Caprioli, R. M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900100-jlr200 · Cited by 158 · see citing works

Early Changes in Protein Expression Detected by Mass Spectrometry Predict Tumor Response to Molecular Therapeutics

Reyzer, M. L., Caldwell, R. L., Dugger, T. C., Forbes, J. T., Ritter, C. A., Guix, M., Arteaga, C. L., & Caprioli, R. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2231 · Cited by 154 · see citing works

Discrimination of Human Astrocytoma Subtypes by Lipid Analysis Using Desorption Electrospray Ionization Imaging Mass Spectrometry

Eberlin, L. S., Dill, A. L., Golby, A. J., et al. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201001452 · Cited by 140 · see citing works

Elevation of sulfatides in ovarian cancer: An integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry

Liu, Y., Chen, Y., Momin, A. A., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-186 · Cited by 130 · see citing works

Liquid ionic matrixes for MALDI mass spectrometry imaging of lipids

Mériaux, C., Franck, J., Wisztorski, M., Salzet, M., & Fournier, I. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.02.010 · Cited by 117 · see citing works

Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix‐assisted laser desorption/ionisation mass spectrometry

Atkinson, S. J., Loadman, P. M., Sutton, C. W., et al. (2007) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.2952 · Cited by 101 · see citing works

Proteomic Patterns of Preinvasive Bronchial Lesions

Rahman, S. M. J., Shyr, Y., Yildiz, P. B., et al. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200502-274oc · Cited by 91 · see citing works

Gastric Cancer-Specific Protein Profile Identified Using Endoscopic Biopsy Samples via MALDI Mass Spectrometry

Kim, H. K., Reyzer, M. L., Choi, I. J., Kim, C. G., Kim, H. S., Oshima, A., Chertov, O., Colantonio, S., Fisher, R. J., Allen, J. L., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr100302b · Cited by 75 · see citing works

A 25-Signal Proteomic Signature and Outcome for Patients With Resected Non–Small-Cell Lung Cancer

Yanagisawa, K., Tomida, S., Shimada, Y., Yatabe, Y., Mitsudomi, T., & Takahashi, T. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djk197 · Cited by 73 · see citing works

Imaging Mass Spectrometry Reveals Unique Protein Profiles during Embryo Implantation

Burnum-Johnson, K., Tranguch, S. L., Mi, D., Daikoku, T., Dey, S. K., & Caprioli, R. M. (2008) · Endocrinology · doi:10.1210/en.2008-0309 · Cited by 69 · see citing works

Differentiating Proteomic Biomarkers in Breast Cancer by Laser Capture Microdissection and MALDI MS

Sanders, M. E., Dias, E. C., Xu, B. J., Mobley, J. A., Billheimer, D. D., Röder, H., Grigorieva, J., Dowsett, M., Arteaga, C. L., & Caprioli, R. M. (2008) · Journal of Proteome Research · doi:10.1021/pr7008109 · Cited by 64 · see citing works

Proteomic profiling of mucosal and submucosal colonic tissues yields protein signatures that differentiate the inflammatory colitides

M’Koma, A. E., Seeley, E. H., Washington, M. K., Schwartz, D. A., Muldoon, R. L., Herline, A. J., Wise, P. E., & Caprioli, R. M. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21442 · Cited by 64 · see citing works

Mass Spectrometry Imaging

(2010) · Methods in molecular biology · doi:10.1007/978-1-60761-746-4 · Cited by 64 · see citing works

A Mass Spectrometry Primer for Mass Spectrometry Imaging

Rubakhin, S. S., & Sweedler, J. V. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-746-4_2 · Cited by 52 · see citing works

Improving Spot Homogeneity by Using Polymer Substrates in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry of Oligonucleotides

Kim, Y., Hurst, G. B., Doktycz, M. J., & Buchanan, M. V. (2001) · Analytical Chemistry · doi:10.1021/ac001392v · Cited by 51 · see citing works

MALDI MS Imaging of Amyloid

Stoeckli, M., Knochenmuss, R., McCombie, G., Mueller, D. R., Rohner, T. C., Staab, D., & Wiederhold, K. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)12007-8 · Cited by 50 · see citing works

Molecular Assessment of the Tumor Protein Microenvironment Using Imaging Mass Spectrometry

Caldwell, R. L., González, A., Oppenheimer, S. R., et al. (2006) · Cancer Genomics & Proteomics · Cited by 40 · see citing works

Identification of Early Intestinal Neoplasia Protein Biomarkers Using Laser Capture Microdissection and MALDI MS

Xu, B. J., Li, J., Beauchamp, R. D., et al. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800345-mcp200 · Cited by 24 · see citing works

Effect of Combined Oral Contraceptives on Breast Epithelial Proliferation in Young Women

y Narvaiza, D. G., Navarrete, M. A. H., Falzoni, R., et al. (2008) · The Breast Journal · doi:10.1111/j.1524-4741.2008.00621.x · Cited by 21 · see citing works

Demonstration of amyloid protein AA in old museum specimens.

Westermark, P., & Gt, N. (1984) · PubMed · Cited by 20 · see citing works

Relationship between the prolongation of warm ischemia and the maximum available preservation period.

Grundmann, R., Eichmann, J., Keckstein, J., et al. (1977) · PubMed · Cited by 13 · see citing works

Primary cell culture of human adenocarcinomas--practical considerations.

Lerescu, L., Ţucureanu, C., Caraș, I., et al. (2009) · PubMed · Cited by 11 · see citing works

Tissue Microarrays from Frozen Tissues-OCT Technique

Fejzo, M. S., & Slamon, D. J. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-806-5_8 · Cited by 8 · see citing works

Exploring the Potential of Cryodetectors for the Detection of Matrix-Assisted Laser Desorption／Ionization Produced Ions： Application to Profiling and Imaging Mass Spectrometry

PierreChaurand, GertraudHayn, & UrsMatter (2004) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 4 · see citing works

Top Down proteomics: Facts and perspectives

Catherman, A. D., Skinner, O. S., & Kelleher, N. L. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.02.041 · Cited by 507 · see citing works

Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity

Cassat, J. E., & Skaar, E. P. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-011-0294-4 · Cited by 155 · see citing works

Matrix-Assisted Laser Desorption Ionization Imaging Mass Spectrometry of Drug Distribution in Mouse Brain Tissue by High-Resolution Time-of-Flight Mass Spectrometry

Satoh, T., Kubo, A., & Hazama, H. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8579-1_13 · Cited by 3 · see citing works

Metabolite imaging by mass spectrometry: A new discovery tool

Walker, H. J. (2020) · Advances in botanical research · doi:10.1016/bs.abr.2020.09.022 · Cited by 8 · see citing works

The application of mass spectrometry imaging in traditional Chinese medicine: a review

Huang, L., Nie, L., Dai, Z., et al. (2022) · Chinese Medicine · doi:10.1186/s13020-022-00586-8 · Cited by 30 · see citing works

Mass spectrometry imaging: Facts and perspectives from a non-mass spectrometrist point of view

Cameron, L. C. (2012) · Methods · doi:10.1016/j.ymeth.2012.06.007 · Cited by 17 · see citing works

Fundamentals of imaging mass spectrometry

Shrestha, B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818998-6.00014-0