The DOI matches its Crossref record.
Mammalian microRNAs derived from genomic repeats
Abstract
In this article, we show that a subset of conventional mammalian microRNAs is derived from LINE-2 transposable elements and other genome repeats. These repeat-derived microRNAs arise from conventional precursor hairpins and are distinct from the rasiRNAs, which appear to be processed from long double-stranded RNA precursors. The insertion of transposable elements into new genomic sites appears to be one of the driving-forces that create new microRNAs during mammalian evolution. Two of the LINE-2-derived microRNAs exhibit perfect complementarity to a large family of mRNA and EST transcripts that contain portions of MIR and other LINE-2 elements in their 3'-untranslated regions.
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A recent report indicated that a number of mammalian miRNAs, including six human miRNAs, are derived from TEs.
“However, a recent report indicated that a number of mammalian miRNAs, including six human miRNAs, are in fact derived from TEs [21].”
From A Family of Human MicroRNA Genes from Miniature Inverted-Repeat Transposable Elements (2007) · cites this paper as [21]
As reported here and elsewhere, more and more TE-derived miRNAs are being discovered.
“However, as reported here and elsewhere [21], more and more TE-derived miRNAs are being discovered.”
From A Family of Human MicroRNA Genes from Miniature Inverted-Repeat Transposable Elements (2007) · cites this paper as [21]
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A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626
Evolution of microRNA diversity and regulation in animals
Berezikov, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3079 · Cited by 712
Kapusta, A., Kronenberg, Z., Lynch, V. J., Zhuo, X., Ramsay, L., Bourque, G., Yandell, M., & Feschotte, C. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003470 · Cited by 687
Restricting retrotransposons: a review
Goodier, J. L. (2016) · Mobile DNA · doi:10.1186/s13100-016-0070-z · Cited by 436
Epigenetic regulation of transposable elements in plants
Lisch, D. (2009) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092744 · Cited by 469
A Family of Human MicroRNA Genes from Miniature Inverted-Repeat Transposable Elements
Piriyapongsa, J., & Jordan, I. K. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000203 · Cited by 283
Exploring the read-write genome: mobile DNA and mammalian adaptation
Shapiro, J. A. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2016.1226748 · Cited by 30
Metadata
- Authors
- SMALHEISER, N., & TORVIK, V
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 21
- Issue
- 6
- Pages
- 322-326
- ISSN
- 0168-9525
- Cited by
- 251
- References
- 0
- Language
- en
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