Evolution of microRNA diversity and regulation in animals
Abstract
In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic expansion in bilaterian animals and their function in providing robustness to transcriptional programmes suggest that miRNAs are instrumental in the evolution of organismal complexity. Advances in understanding miRNA biology, combined with the increasing availability of diverse sequenced genomes, have begun to reveal the molecular mechanisms that underlie the evolution of miRNAs and their targets. Insights are also emerging into how the evolution of miRNA-containing regulatory networks has contributed to organismal complexity.
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Given the expansion of miRNA genes in vertebrates, the molecular mechanism revealed in this study has broader implications in understanding how function of new miRNA genes might evolve in humans.
“In addition, given the expansion of miRNA genes in vertebrates7,8, the molecular mechanism revealed in this present study also has broader implications in understanding how function of new miRNA genes might evolve in humans.”
From Gain-of-function mutation of microRNA-140 in human skeletal dysplasia (2019) · cites this paper as [8]
More than 100 primate-specific and 20 human-specific microRNAs are expressed in the developing brain.
“For example, there are more than 100 primate-specific, and 20 human-specific microRNAs that are expressed in the developing brain (Berezikov, 2011).”
From Genetic Changes Shaping the Human Brain (2015) · cites this paper as Berezikov, 2011
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- Authors
- Berezikov, E.
- Venue
- Nature Reviews Genetics
- Published
- 2011-11-18
- Volume
- 12
- Issue
- 12
- Pages
- 846-860
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2013868665
- Semantic Scholar
- 1d6560ab868a2b61fa995ab7185aedb01dda65c8
- Cited by
- 712
- References
- 14
- Citations by year
- 2026: 7 · 2025: 34 · 2024: 35 · 2023: 21 · 2022: 31 · 2021: 45 · 2020: 46 · 2019: 51 · 2018: 41 · 2017: 61 · 2016: 76 · 2015: 67 · 2014: 76 · 2013: 68 · 2012: 52
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- miRNA evolution, post-transcriptional regulation, organismal complexity, gene regulatory networks, animal genomes
- MeSH terms
- Animals, Base Sequence, Gene Expression Regulation, Phylogeny, Genetic Variation, Evolution, Molecular, MicroRNAs
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