The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Maintenance of ancestral complexity and non-metazoan genes in two basal cnidarians
Abstract
Cnidarians are among the simplest extant animals; however EST analyses reveal that they have a remarkably high level of genetic complexity. In this article, we show that the full diversity of metazoan signaling pathways is represented in this phylum, as are antagonists previously known only in chordates. Many of the cnidarian ESTs match genes previously known only in non-animal kingdoms. At least some of these represent ancient genes lost by all bilaterians examined so far, rather than genes gained by recent lateral gene transfer.
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In the citing paper
“Nematostella has a surprisingly complex genome, including all major signalling pathways and most transcription factor families [18,20–24].”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [20]
In the citing paper
“diverged organisms characterized by high levels of gene loss and sequence divergence, whereas at least some cnidarians have retained much of the ancestral genetic complexity of metazoans [108–110].”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [109]
In the citing paper
“Reflecting this ancestral core, cnidarian genes are often more similar to vertebrate genes than vertebrate genes are to those of more diverged animals like Caenorhabditis or Drosophila [50,109].”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [109]
In the citing paper
“the anemone genome harbors two families of Tx1-like non-LTR retrotransposons, Tx1-1_NV and Tx1-2_NV, inserted in 5S rRNA and U2 smRNA, respectively, at target sites identical to those of different Tx1 elements in fish (18), frog and lancelet.”
From Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization (2007) · cites this paper as [18]
Citations
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Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
Putnam, N. H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V. V., et al. (2007) · Science · doi:10.1126/science.1139158 · Cited by 1,555
Self-citationChapman, J. A., Kirkness, E. F., Simakov, O., Hampson, S. E., Mitros, T., Weinmaier, T., Rattei, T., Balasubramanian, P. G., Borman, J., Busam, D., et al. (2010) · Nature · doi:10.1038/nature08830 · Cited by 810
Self-citationThe frailty of adaptive hypotheses for the origins of organismal complexity
Lynch, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702207104 · Cited by 829
Albalat, R., & Cañestro, C. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.39 · Cited by 775
The relationship between non‐protein‐coding DNA and eukaryotic complexity
Taft, R. J., Pheasant, M., & Mattick, J. S. (2007) · BioEssays · doi:10.1002/bies.20544 · Cited by 731
Metadata
- Authors
- Technau, U., Rudd, S., Maxwell, P., Gordon, P. M. K., Saina, M., Grasso, L. C., Hayward, D. C., Sensen, C. W., Saint, R., Holstein, T. W., Ball, E. E., & Miller, D. J.
- Affiliations
- University of Bergen (NO)
- Turku Centre for Biotechnology (FI)
- Australian National University (AU)
- University of Calgary (CA)
- Heidelberg University (DE)
- James Cook University (AU)
- Corresponding author
- Technau, Ulrich
- Miller, David J.
- ORCID
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 21
- Issue
- 12
- Pages
- 633-639
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2076271968
- Cited by
- 337
- References
- 49
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 3 · 2020: 3 · 2019: 10 · 2018: 3 · 2017: 13 · 2016: 17 · 2015: 18 · 2014: 15 · 2013: 11 · 2012: 19
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- ResearchOnline at James Cook University (James Cook University) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- ancestral genes, gene loss, horizontal gene transfer, expressed sequence tags, gene family evolution, bilaterians
- MeSH terms
- Animals, Bacterial Proteins, Genetics, Population, Heat-Shock Proteins, Humans, Phylogeny, Genes, Duplicate, Anthozoa
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