The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Genome-wide transcription factor binding: beyond direct target regulation
Open accessAbstract
The binding of transcription factors to specific DNA target sequences is the fundamental basis of gene regulatory networks. Chromatin immunoprecipitation combined with DNA tiling arrays or high-throughput sequencing—ChIP-chip and ChIP-seq—has produced many recent studies that detail the binding sites of various transcription factors. Surprisingly, data from a variety of model organisms and tissues have demonstrated that transcription factors vary greatly in their number of genomic binding sites, and that binding events can significantly exceed the number of known or possible direct gene targets. Thus, our current understanding of transcription factor function must expand to encompass what role, if any, binding might play outside of direct transcriptional target regulation. Here, we discuss the biological significance of genome-wide binding of transcription factors and present models that can account for this phenomenon.
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Cites
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Absence of a simple code: how transcription factors read the genome
Slattery, M., Zhou, T., Yang, L., Dantas Machado, A. C., Gordân, R., & Rohs, R. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.07.002 · Cited by 537
The Mycobacterium tuberculosis regulatory network and hypoxia
Galagan, J. E., Minch, K., Peterson, M., Lyubetskaya, A., Azizi, E., Sweet, L., Gomes, A., Rustad, T., Dolganov, G., Glotova, I., et al. (2013) · Nature · doi:10.1038/nature12337 · Cited by 431
Metadata
- Authors
- MacQuarrie, K. L., Fong, A. P., Morse, R. H., & Tapscott, S. J.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 27
- Issue
- 4
- Pages
- 141-148
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2116194650
- Cited by
- 217
- References
- 9
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
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- MacQuarrie, K. L., Fong, A. P., Morse, R. H., & Tapscott, S. J. (2011). Genome-wide transcription factor binding: beyond direct target regulation. Trends in Genetics. https://doi.org/10.1016/j.tig.2011.01.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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