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Cited by 238Evolution and Genetic DynamicsGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesChromosomal and Genetic Variations

The faster-X effect: integrating theory and data

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Meisel, Richard P., Connallon, Tim·2013·Trends in Genetics
DOI 10.1016/j.tig.2013.05.009PMC PMC3755111
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Abstract

Population genetics theory predicts that X (or Z) chromosomes could play disproportionate roles in speciation and evolutionary divergence, and recent genome-wide analyses have identified situations in which X or Z-linked divergence exceeds that on the autosomes (the so-called 'faster-X effect'). Here, we summarize the current state of both the theory and data surrounding the study of faster-X evolution. Our survey indicates that the faster-X effect is pervasive across a taxonomically diverse array of evolutionary lineages. These patterns could be informative of the dominance or recessivity of beneficial mutations and the nature of genetic variation acted upon by natural selection. We also identify several aspects of disagreement between these empirical results and the population genetic models used to interpret them. However, there are clearly delineated aspects of the problem for which additional modeling and collection of genomic data will address these discrepancies and provide novel insights into the population genetics of adaptation.

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  • Half of the false negatives may be related to faster X chromosome evolution.

    “Manual investigation of misclassifications showed that false positives mostly represent partial or full gene duplications (actual co-orthologous loci) and that half of the false negatives may be related to faster X chromosome evolution (17) (fig. S5–S6).”

    From Integrating gene annotation with orthology inference at scale (2023) · cites this paper as [17]

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Authors
Meisel, R. P., & Connallon, T.
Affiliations
Cornell University (US)
Corresponding author
Meisel, Richard P.
ORCID
Venue
Trends in Genetics
Publisher
Elsevier BV
Published
2013-09
Volume
29
Issue
9
Pages
537-544
ISSN
0168-9525 (ISSN-L)
DOI
10.1016/j.tig.2013.05.009
PMC
PMC3755111
OpenAlex
W2171269638
Cited by
238
References
2
Citations by year
2026: 17 · 2025: 14 · 2024: 25 · 2023: 15 · 2022: 44 · 2021: 18 · 2020: 11 · 2019: 12 · 2018: 25 · 2017: 11 · 2016: 17 · 2015: 18 · 2014: 10 · 2013: 1
FWCI
1.86
Type
journal article
Language
en
Open access
Licence
Locations
  • Trends in Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (R01GM064590)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords
X chromosome, Z chromosome, sex chromosomes, speciation, evolutionary divergence, autosomes, natural selection, population genetic models
MeSH terms
Adaptation, Physiological, Animals, Pan troglodytes, Drosophila, Genetics, Population, Humans, Models, Genetic, Mutation, Selection, Genetic, Genetic Variation, X Chromosome, Evolution, Molecular, Empirical Research, Genetic Loci, Genetic Association Studies

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