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Revisiting the Relationship between Transposable Elements and the Eukaryotic Stress Response
Abstract
A relationship between transposable elements (TEs) and the eukaryotic stress response was suggested in the first publications describing TEs. Since then, it has often been assumed that TEs are activated by stress, and that this activation is often beneficial for the organism. In recent years, the availability of new high-throughput experimental techniques has allowed further interrogation of the relationship between TEs and stress. By reviewing the recent literature, we conclude that although there is evidence for a beneficial effect of TE activation under stress conditions, the relationship between TEs and the eukaryotic stress response is quite complex.
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“and as sensors of cellular stress [11]”
From The case for not masking away repetitive DNA (2018) · cites this paper as [11]
Citations
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Transposable elements and the epigenetic regulation of the genome
Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044
Regulatory evolution of innate immunity through co-option of endogenous retroviruses
Chuong, E. B., Elde, N. C., & Feschotte, C. (2016) · Science · doi:10.1126/science.aad5497 · Cited by 1,008
Van Meter, M., Kashyap, M., Rezazadeh, S., Geneva, A. J., Morello, T. D., Seluanov, A., & Gorbunova, V. (2014) · Nature Communications · doi:10.1038/ncomms6011 · Cited by 456 · cited 1×
“Under stress conditions and also during aging, SIRT6 relocates to DNA damage sites, and as a consequence LINE-1s are no longer kept in a heterochromatic state and are thus transcribed [34], thereby indirectly leading to the activation of LINE-1 elements.”
Background
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Metadata
- Authors
- Horváth, V., Merenciano, M., & González, J.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 33
- Issue
- 11
- Pages
- 832-841
- ISSN
- 0168-9525
- Cited by
- 219
- References
- 3
- Language
- en
- Funders
- European Research Council
- Spanish Ministry of Economy and Competitivity
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