miRNA Targeting: Growing beyond the Seed
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Additional pairing between nucleotides in the 3' half of the miRNA and the target mRNA also contributes to miRNA-mediated gene targeting.
“Additional pairing between nucleotides in the 3′ half of the miRNA and the target mRNA also contribute to miRNA‐mediated gene targeting (reviewed in Chipman & Pasquinelli, 2019).”
From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Chipman & Pasquinelli, 2019
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works
Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits
Xue, Y., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2012.11.045 · Cited by 562 · see citing works
Pairing beyond the Seed Supports MicroRNA Targeting Specificity
Broughton, J. P., Lovci, M. T., Huang, J. L., Yeo, G. W., & Pasquinelli, A. E. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.004 · Cited by 487 · see citing works
Interplay between miRNAs and human diseases
Paul, P., Chakraborty, A., Sarkar, D., Langthasa, M., Rahman, M., Bari, M., Singha, R. S., Malakar, A. K., & Chakraborty, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25854 · Cited by 420 · cited 1× · see citing works
“Given this omnipresent role in gene regulation, it is not surprising that misregulation of individual miRNAs can have dire consequences, contributing to a variety of diseases and afflictions in humans [6].”
Moore, M. J., Scheel, T. K. H., Luna, J. M., Park, C. Y., Fak, J. J., Nishiuchi, E., Rice, C. M., & Darnell, R. B. (2015) · Nature Communications · doi:10.1038/ncomms9864 · Cited by 326 · see citing works
Flagged first, then by citations
Research works printed but not linked: 37
- [3]Kozomara A (2018) miRBase: from microRNA sequences to function. Nucleic Acids Res. DOI: 10.1093/nar/gky1141 PMC6323917 30423142 · DOI · Paper page
- [4]Bartel DP (2018) Metazoan MicroRNAs. Cell 173, 20– 51 29570994 PMC6091663
- [5]Liu H (2018) Small but powerful: function of microRNAs in plant development. Plant Cell Rep. 37, 515– 528 29318384
- [7]Gebert LFR and MacRae IJ (2018) Regulation of microRNA function in animals. Nat. Rev. Mol. Cell Biol DOI: 10.1038/s41580-018-0045-7 PMC6546304 30108335 · DOI · Paper page
- [8]Elkayam E (2012) The structure of human argonaute-2 in complex with miR-20a. Cell 150, 100– 110 22682761 PMC3464090
- [9]Nakanishi K (2012) Structure of yeast Argonaute with guide RNA. Nature 486, 368– 374 22722195 PMC3853139
- [10]Schirle NT and MacRae IJ (2012) The Crystal Structure of Human Argonaute2. Science 336, 1037– 1040 22539551 PMC3521581
- [11]Chandradoss SD (2015) A Dynamic Search Process Underlies MicroRNA Targeting. Cell 162, 96– 107 26140593 PMC4768356
- [12]Jo MH (2015) Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs. Mol. Cell 59, 117– 124 26140367
- [13]Salomon WE (2015) Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides. Cell 162, 84– 95 26140592 PMC4503223
- [14]Schirle NT (2014) Structural basis for microRNA targeting. Science 346, 608– 13 25359968 PMC4313529
- [15]Yan Y (2018) The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides. Nucleic Acids Res. 46, 8181– 8196 30239883 PMC6144789
- [16]Helwak A (2013) Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding. Cell 153, 654– 665 23622248 PMC3650559
- [17]Grosswendt S (2014) Unambiguous Identification of miRNA: Target site interactions by different types of ligation reactions. Mol. Cell 54, 1042– 1054 24857550 PMC4181535
- [20]Reinhart BJ (2000) The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403, 901– 906 10706289
- [21]Slack FJ (2000) The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor. Molecular 5, 659– 669 10882102
- [22]Brancati G and Großhans H (2018) An interplay of miRNA abundance and target site architecture determines miRNA activity and specificity. Nucleic Acids Res. 46, 3259– 3269 29897601 PMC5909448
- [23]Chi SW (2009) Argonaute HITS-CLIP decodes microRNA – mRNA interaction maps. Nature 460, 479– 486 19536157 PMC2733940
- [24]Hafner M (2010) Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP. Cell 141, 129– 141 20371350 PMC2861495
- [25]Zisoulis DG (2010) Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Nat. Struct. Mol. Biol 17, 173– 179 20062054 PMC2834287
- [27]Duursma AM (2008) miR-148 targets human DNMT3b protein coding region. RNA 14, 872– 7 18367714 PMC2327368
- [28]Tay Y (2008) MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 455, 1124– 1128 18806776
- [29]Hausser J (2013) Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation. Genome Res. 23, 604– 615 23335364 PMC3613578
- [30]Gu S (2009) Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs. Nat. Struct. Mol. Biol 16, 144– 150 19182800 PMC2713750
- [31]Zhang K (2018) A novel class of microRNA-recognition elements that function only within open reading frames. Nat. Struct. Mol. Biol DOI: 10.1038/s41594-018-0136-3 PMC6219929 30297778 · DOI
- [32]Cai Z (2015) Oncogenic miR-17/20a forms a positive feed-forward loop with the p53 kinase DAPK3 to promote tumorigenesis. J. Biol. Chem 290, 19967– 19975 26117336 PMC4528155
- [33]Ameres SL (2010) Target RNA-directed trimming and tailing of small silencing RNAs. Science 328, 1534– 9 20558712 PMC2902985
- [34]Cazalla D (2010) Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA. Science 328, 1563– 6 20558719 PMC3075239
- [35]Fuchs Wightman F (2018) Target RNAs strike back on microRNAs. Front. Genet 9, 435 30333855 PMC6175985
- [36]Baccarini A (2011) Kinetic analysis reveals the fate of a MicroRNA following target regulation in mammalian cells. Curr. Biol 21, 369– 376 21353554 PMC3088433
- [37]Libri V (2012) Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target. Proc. Natl. Acad. Sci 109, 279– 284 22184245 PMC3252920
- [38]Marcinowski L (2012) Degradation of cellular mir-27 by a novel, highly abundant viral transcript is important for efficient virus replication in vivo. PLoS Pathog. 8, e1002510 22346748 PMC3276556
- [39]Lee S (2013) Selective degradation of host MicroRNAs by an intergenic HCMV noncoding RNA accelerates virus production. Cell Host Microbe 13, 678– 690 23768492
- [40]Bitetti A (2018) MicroRNA degradation by a conserved target RNA regulates animal behavior. Nat. Struct. Mol. Biol 25, 244– 251 29483647
- [41]Kleaveland B (2018) A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Cell 174, 350– 362.e17 29887379 PMC6559361
- [42]Ghini F (2018) Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation. Nat. Commun 9, 3119 30087332 PMC6081425
- [43]Ulitsky I (2011) Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution. Cell 147, 1537– 50 22196729 PMC3376356
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microRNA strand selection: Unwinding the rules
Medley, J. C., Panzade, G., & Zinovyeva, A. Y. (2021) · WIREs RNA · doi:10.1002/wrna.1627 · Cited by 225 · see citing works
Xu, Z., Sziraki, A., Lee, J., Zhou, W., & Cao, J. (2024) · Nature Biotechnology · doi:10.1038/s41587-023-01948-9 · Cited by 52 · see citing works
MicroRNAs As Novel Biomarkers and Potential Therapeutic Options for Inflammatory Cardiomyopathy
Aleshcheva, G., Baumeier, C., Harms, D., Bock, C.-T., Escher, F., & Schultheiss, H.-P. (2023) · ESC Heart Failure · doi:10.1002/ehf2.14523 · Cited by 17 · see citing works
- Authors
- Chipman, L. B., & Pasquinelli, A. E.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 35
- Issue
- 3
- Pages
- 215-222
- ISSN
- 0168-9525
- PMC
- PMC7083087
- Cited by
- 248
- References
- 6
- Language
- en
- Funders
- National Institute of General Medicine (T32 GM007240, R35 GM127012)
- National Science Foundation Graduate Research Fellowship (DGE-1650112)
- National Institute on Aging (R01 AG056562)
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