Interplay between miRNAs and human diseases

Hallmarks of Cancer: The Next Generation

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Untitled work

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MicroRNAs: Target Recognition and Regulatory Functions

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

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Circulating microRNAs as stable blood-based markers for cancer detection

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Real-time quantification of microRNAs by stem-loop RT-PCR

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miRBase: microRNA sequences, targets and gene nomenclature

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Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

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Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

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MicroRNA Gene Expression Deregulation in Human Breast Cancer

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Unique microRNA molecular profiles in lung cancer diagnosis and prognosis

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsPreprint

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The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation

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Nuclear Export of MicroRNA Precursors

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MicroRNA maturation: stepwise processing and subcellular localization

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Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

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A pancreatic islet-specific microRNA regulates insulin secretion

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MicroRNA-133 controls cardiac hypertrophy

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MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

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The Diverse Functions of MicroRNAs in Animal Development and Disease

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Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA

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Reduced accumulation of specific microRNAs in colorectal neoplasia.

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Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis

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A Polycistronic MicroRNA Cluster, miR-17-92 , Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation

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Serum MicroRNAs Are Promising Novel Biomarkers

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Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

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Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

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Widespread microRNA repression by Myc contributes to tumorigenesis

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The role of microRNA genes in papillary thyroid carcinoma

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Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues

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Extensive modulation of a set of microRNAs in primary glioblastoma

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A microRNA DNA methylation signature for human cancer metastasis

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Getting to the Root of miRNA-Mediated Gene Silencing

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Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster

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MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb

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microRNAs exhibit high frequency genomic alterations in human cancer

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The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism

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MicroRNAs 103 and 107 regulate insulin sensitivity

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MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

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Extensive post-transcriptional regulation of microRNAs and its implications for cancerPreprint

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miR-133 and miR-30 Regulate Connective Tissue Growth Factor

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Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline

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An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues

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A custom microarray platform for analysis of microRNA gene expression

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<i>miR-375</i> maintains normal pancreatic α- and β-cell mass

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MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-β-induced collagen expression via inhibition of E-box repressors

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Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

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Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease

Corsten, M. F., Dennert, R., Jochems, S., Kuznetsova, T., Devaux, Y., Hofstra, L., Wagner, D. R., Staessen, J. A., Heymans, S., & Schroen, B. (2010) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.110.957415 · Cited by 677 · see citing works

IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

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Therapeutic Inhibition of miR-208a Improves Cardiac Function and Survival During Heart Failure

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MicroRNAs Add a New Dimension to Cardiovascular Disease

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TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN

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Mechanisms of microRNA-mediated gene regulation in animal cells

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Circulating microRNAs as novel biomarkers for diabetes mellitus

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Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study

Kong, L., Zhu, J., Han, W., Jiang, X., Xu, M., Zhao, Y., Dong, Q., Pang, Z., Guan, Q., Gao, L., et al. (2010) · Acta Diabetologica · doi:10.1007/s00592-010-0226-0 · Cited by 529 · see citing works

Rapid Alteration of MicroRNA Levels by Histone Deacetylase Inhibition

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MicroRNAs in cardiovascular disease: an introduction for clinicians

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Plasma miR-208 as a Biomarker of Myocardial Injury

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Targeted Inhibition of miRNA Maturation with Morpholinos Reveals a Role for miR-375 in Pancreatic Islet Development

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Epigenetic inactivation of microRNA gene hsa‐mir‐9‐1 in human breast cancer

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MicroRNA-181b regulates NF-κB–mediated vascular inflammation

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Epigenetic regulation of microRNA expression in colorectal cancer

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The Aquaporin Water Channels

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MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus

Karolina, D. S., Armugam, A., Subramaniam, T., Wong, M. T. K., Lim, S. C., Sum, C. F., & Jeyaseelan, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022839 · Cited by 434 · see citing works

miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells

Ouaamari, A. E., Baroukh, N., Martens, G. A., Lebrun, P., PIPELEERS, D. G., & OBBERGHEN, E. V. (2008) · Diabetes · doi:10.2337/db07-1614 · Cited by 430 · see citing works

Inhibition of miR-25 improves cardiac contractility in the failing heart

Wahlquist, C., Jeong, D., Rojas‐Muñoz, A., Kho, C., Lee, A. A., Mitsuyama, S., van Mil, A., Park, W. J., Sluijter, J. P. G., Doevendans, P. A., et al. (2014) · Nature · doi:10.1038/nature13073 · Cited by 412 · see citing works

MicroRNA‐377 is up‐regulated and can lead to increased fibronectin production in diabetic nephropathy

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Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia

Caporali, A., Meloni, M., Völlenkle, C., Bonci, D., Sala-Newby, G. B., Addis, R., Spinetti, G., Losa, S., Masson, R., Baker, A. H., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.952325 · Cited by 397 · see citing works

Epigenetic Silencing of the Myelopoiesis Regulator microRNA-223 by the AML1/ETO Oncoprotein

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microRNAs in Cardiovascular Diseases

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Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?

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Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA

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miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes

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Podocyte-Selective Deletion of Dicer Induces Proteinuria and Glomerulosclerosis

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miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression

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Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs

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Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

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DNA methylation regulates microRNA expression

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MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic β-Cell Lines*

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Antisense-Mediated Depletion Reveals Essential and Specific Functions of MicroRNAs in Drosophila Development

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Podocyte-Specific Deletion of Dicer Alters Cytoskeletal Dynamics and Causes Glomerular Disease

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Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathwayPreprint

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MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment

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MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages

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MicroRNA‐320 EXPRESSION IN MYOCARDIAL MICROVASCULAR ENDOTHELIAL CELLS AND ITS RELATIONSHIP WITH INSULIN‐LIKE GROWTH FACTOR‐1 IN TYPE 2 DIABETIC RATS

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MicroRNA-29c Is a Signature MicroRNA under High Glucose Conditions That Targets Sprouty Homolog 1, and Its in Vivo Knockdown Prevents Progression of Diabetic Nephropathy

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Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients

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E-Cadherin Expression Is Regulated by miR-192/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor-β

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Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes

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Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

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MicroRNA Dysregulation in Diabetic Ischemic Heart Failure Patients

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A microRNA cluster as a target of genomic amplification in malignant lymphoma

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Long-Term Cardiac-Targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy

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CpG Island Hypermethylation of Tumor Suppressor microRNAs in Human Cancer

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miR‐1/miR‐206 regulate Hsp60 expression contributing to glucose‐mediated apoptosis in cardiomyocytes

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Hypertension in Autosomal-Dominant Polycystic Kidney Disease

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MicroRNA-29a Promotion of Nephrin Acetylation Ameliorates Hyperglycemia-Induced Podocyte Dysfunction

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MicroRNA-155 Silencing Enhances Inflammatory Response and Lipid Uptake in Oxidized Low-Density Lipoprotein-Stimulated Human THP-1 Macrophages

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Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification

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The bantam Gene Regulates Drosophila Growth

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microRNAs and the regulation of glucose and lipid metabolism

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Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells

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Recent Progress in HIV-Associated Nephropathy

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Post-transcriptional Up-regulation of Tsc-22 by Ybx1, a Target of miR-216a, Mediates TGF-β-induced Collagen Expression in Kidney Cells*

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MicroRNA 320a Functions as a Novel Endogenous Modulator of Aquaporins 1 and 4 as Well as a Potential Therapeutic Target in Cerebral Ischemia*

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miR-195 regulates SIRT1-mediated changes in diabetic retinopathy

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Urinary miR-21, miR-29, and miR-93: Novel Biomarkers of Fibrosis

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The MicroRNA-Processing Enzyme Dicer Maintains Juxtaglomerular Cells

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The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity

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MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3

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MicroRNAs in Diabetic Nephropathy: From Biomarkers to Therapy

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Myc: Maestro of MicroRNAs

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miR-200b Precursor Can Ameliorate Renal Tubulointerstitial Fibrosis

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Interplay between HIV-1 infection and host microRNAs

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microRNA-based diagnostics and therapy in cardiovascular disease-Summing up the facts.

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Increased expression of microRNA miR‐326 in type 1 diabetic patients with ongoing islet autoimmunity

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Low‐dose paclitaxel ameliorates fibrosis in the remnant kidney model by down‐regulating miR‐192

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The TGFβ–miR200–MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors

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Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease

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MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation

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Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells

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MiRNA-155 targets myosin light chain kinase and modulates actin cytoskeleton organization in endothelial cells

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Improved repair of dermal wounds in mice lacking micro<scp>RNA</scp>‐155

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Strong reduction of AGO2 expression in melanoma and cellular consequences

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miRNA-548c: A specific signature in circulating PBMCs from dilated cardiomyopathy patients

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Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies

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Nrf2 Pathway in Age-Related Neurological Disorders: Insights into MicroRNAs

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MicroRNA Networks in Pancreatic Islet Cells: Normal Function and Type 2 Diabetes

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Glucocorticoid Receptor Signaling in Diabetes

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Green Tea Prevents NAFLD by Modulation of miR-34a and miR-194 Expression in a High-Fat Diet Mouse Model

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miRNAs as Therapeutic Tools in Alzheimer’s Disease

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Genetically Engineered-MSC Therapies for Non-unions, Delayed Unions and Critical-size Bone Defects

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A comprehensive review on oncogenic miRNAs in breast cancer

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Members of the microRNA-200 family are promising therapeutic targets in cancer

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MicroRNA Schizophrenia: Etiology, Biomarkers and Therapeutic Targets.

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miR-206 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells by targetting glutaminase

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ESAT-6 modulates Calcimycin-induced autophagy through microRNA-30a in mycobacteria infected macrophages

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Hsa_circ_0011385 accelerates the progression of thyroid cancer by targeting miR-361-3p

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Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors

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Diosmin Mitigates Gentamicin-Induced Nephrotoxicity in Rats: Insights on miR-21 and -155 Expression, Nrf2/HO-1 and p38-MAPK/NF-κB Pathways

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MiR‐210‐3p inhibits osteogenic differentiation and promotes adipogenic differentiation correlated with Wnt signaling in ERα‐deficient rBMSCs

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Circulating miRNAs, Small but Promising Biomarkers for Autism Spectrum Disorder

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Pathogenetic analysis of polycystic ovary syndrome from the perspective of omics

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MicroRNA-1270 modulates papillary thyroid cancer cell development by regulating SCAI

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New Possibilities in the Therapeutic Approach to Alzheimer’s Disease

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Circulating miRNA Profiling in Plasma Samples of Ovarian Cancer Patients

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MiR-29a regulates the proliferation, aromatase expression, and estradiol biosynthesis of human granulosa cells in polycystic ovary syndrome

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MicroRNA in localized scleroderma: a review of literature

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Exosome microRNAs in Metabolic Syndrome as Tools for the Early Monitoring of Diabetes and Possible Therapeutic Options

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Epitranscriptomics: A New Layer of microRNA Regulation in Cancer

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Circulating Neuroendocrine Tumor Biomarkers: Past, Present and Future

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MicroRNA-299-3p suppresses proliferation and invasion by targeting VEGFA in human colon carcinoma

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An Insight Into the Mechanism of Plant Organelle Genome Maintenance and Implications of Organelle Genome in Crop Improvement: An Update

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Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential

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Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer’s Disease: Recent Trends and Future Development

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miR-149-5p protects against high glucose-induced pancreatic beta cell apoptosis via targeting the BH3-only protein BIM

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Critical contribution of 3′ non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA

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The Complex Interaction between P53 and miRNAs Joins New Awareness in Physiological Stress Responses

Capaccia, C., Diverio, S., Zampini, D., & Guelfi, G. (2022) · Cells · doi:10.3390/cells11101631 · Cited by 29 · see citing works

miR-15a-5p enhances the malignant phenotypes of colorectal cancer cells through the STAT3/TWIST1 and PTEN/AKT signaling pathways by targeting SIRT4

Deng, J., Wang, H., Liang, Y., Zhao, L., Li, Y., Yan, Y., Zhao, H., Zhang, X., & Zou, F. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110517 · Cited by 29 · see citing works

MicroRNAs and Human Disease

Vega-Martínez, O., Abdel, F., Heeckt, P., Chaves-Martínez, L., Lin-Shiao, E., Valverde-Hernández, J. C., Mora-Rodríguez, R., Alpízar‐Alpízar, W., & Marín‐Müller, C. (2026) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0029869

Dynamic interplay of microRNA in diseases and therapeutic

Kargutkar, N., Hariharan, P., & Nadkarni, A. H. (2022) · Clinical Genetics · doi:10.1111/cge.14256 · Cited by 34 · see citing works

miRNAs in Health and Disease

Kaymaz, T. (2026) · Turkish Journal of Science and Technology · doi:10.55525/tjst.1989356

Sağlık ve Hastalıkta miRNA'lar

Kaymaz, T. (2026) · DergiPark (Istanbul University)

Pleiotropic Effects of MicroRNA in Health and Disease

Dumitras, E. A., Ciocoiu, M., & Grigoraș, I. (2021) · Journal of Medical and Health Studies · doi:10.32996/jmhs.2021.2.2.10