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The Biogenesis and Precise Control of RNA m6A Methylation
Open accessAbstract
N6-methyladenosine (m6A) is the most prevalent internal RNA modification in messenger RNA (mRNA) and has been found to be highly conserved and hard-coded in mammals and other eukaryotic species. The importance of m6A on gene expression regulation and cell fate decision has been well acknowledged in the past few years. However, it was only until recently that the mechanisms underlying the biogenesis and decision of m6A modification in cells were illustrated. Here, we review up-to-date knowledge on the biogenesis of RNA m6A modification, including the cis-regulatory element and trans-acting factors that determine general de novo m6A deposition and modulate cell type-specific m6A patterns, and discuss the biological significance of such regulations.
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Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884
N6-methyladenosine-dependent regulation of messenger RNA stability
Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. (2014) · Nature · doi:10.1038/nature12730 · Cited by 4,558
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Wang, X., Zhao, B. S., Roundtree, I. A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., & He, C. (2015) · Cell · doi:10.1016/j.cell.2015.05.014 · Cited by 3,483
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1432 · Cited by 3,433
Dynamic RNA Modifications in Gene Expression Regulation
Roundtree, I. A., Evans, M. E., Pan, T., & He, C. (2017) · Cell · doi:10.1016/j.cell.2017.05.045 · Cited by 3,399
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Huang, H., Weng, H., Sun, W., Qin, X., Shi, H., Wu, H., Zhao, B. S., Mesquita, A., Liu, C., Yuan, C. L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0045-z · Cited by 2,997
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Cited by
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Zhang, H., Liu, J., Zhou, Y., Qu, M., Wang, Y., Guo, K., Shen, R., Sun, Z., Cata, J. P., Yang, S., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.69141 · Cited by 336
Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation
Kan, R. L., Chen, J., & Sallam, T. (2022) · Trends in Genetics · doi:10.1016/j.tig.2021.06.014 · Cited by 308
Self-citationH3K36 trimethylation-mediated biological functions in cancer
Xiao, C., Fan, T., Tian, H., Zheng, Y., Zhou, Z., Li, S., Li, C., & He, J. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01187-2 · Cited by 63
Metadata
- Authors
- Huang, H., Weng, H., & Chen, J.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 36
- Issue
- 1
- Pages
- 44-52
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2994203027
- Cited by
- 304
- References
- 87
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- green
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