Bacterial contributions to mammalian gut development

Biological roles of oligosaccharides: all of the theories are correct

Varki, A. P. (1993) · Glycobiology · doi:10.1093/glycob/3.2.97 · Cited by 5,229

MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT

Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436

H OW H OST -M ICROBIAL I NTERACTIONS S HAPE THE N UTRIENT E NVIRONMENT OF THE M AMMALIAN I NTESTINE

Hooper, L. V., Midtvedt, T., & Gordon, J. I. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.011602.092259 · Cited by 1,623

Allergy, Parasites, and the Hygiene Hypothesis

Yazdanbakhsh, M., Kremsner, P. G., & van Ree, R. (2002) · Science · doi:10.1126/science.296.5567.490 · Cited by 1,527

Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut

Suau, A., Bonnet, R., Sutren, M., Godon, J.-J., Gibson, G. R., Collins, M. D., & Doré, J. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.11.4799-4807.1999 · Cited by 1,490

Anatomical basis of tolerance and immunity to intestinal antigens

Mowat, A. M. (2003) · Nature reviews. Immunology · doi:10.1038/nri1057 · Cited by 1,414

Developmental microbial ecology of the neonatal gastrointestinal tract

Mackie, R. I., Sghir, A., & Gaskins, H. R. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.5.1035s · Cited by 1,360

Human Fecal Flora: The Normal Flora of 20 Japanese-Hawaiians

Moore, W. E. C., & Holdeman, L. V. (1974) · Applied Microbiology · doi:10.1128/am.27.5.961-979.1974 · Cited by 1,144

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells

Stappenbeck, T. S., Hooper, L. V., & Gordon, J. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202604299 · Cited by 1,095

Angiogenins: a new class of microbicidal proteins involved in innate immunity

Hooper, L. V., Stappenbeck, T. S., Hong, C. V., & Gordon, J. I. (2003) · Nature Immunology · doi:10.1038/ni888 · Cited by 947

A Model of Host-Microbial Interactions in an Open Mammalian Ecosystem

Bry, L., Falk, P. G., Midtvedt, T., & Gordon, J. I. (1996) · Science · doi:10.1126/science.273.5280.1380 · Cited by 607

A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem

Hooper, L. V., Xu, J., Falk, P. G., Midtvedt, T., & Gordon, J. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9833 · Cited by 500

Crohn's disease

Shanahan, F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07284-7 · Cited by 478

Expression of NOD2 in Paneth cells: a possible link to Crohn’s ileitis

Ogura, Y., Lala, S. G., Xin, W., Smith, E., Dowds, T. A., Chen, F. F., Zimmermann, E., Tretiakova, M., Cho, J. H., Hart, J., et al. (2003) · Gut · doi:10.1136/gut.52.11.1591 · Cited by 459

The multifaceted Paneth cell

Porter, E. M., Bevins, C. L., Ghosh, D., & Ganz, T. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8412-z · Cited by 432

Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut

Shroff, K. E., Meslin, K., & Cebra, J. J. (1995) · Infection and Immunity · doi:10.1128/iai.63.10.3904-3913.1995 · Cited by 395

Inflammatory bowel disease and domestic hygiene in infancy

Gent, A. E., Hellier, M. D., Grace, R. H., Swarbrick, E. T., & Coggon, D. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91841-4 · Cited by 351

Segmented Filamentous Bacteria Are Indigenous Intestinal Bacteria That Activate Intraepithelial Lymphocytes and Induce MHC Class II Molecules and Fucosyl Asialo GM1 Glycolipids on the Small Intestinal Epithelial Cells in the Ex‐Germ‐Free Mouse

Umesaki, Y., Okada, Y., Matsumoto, S., Imaoka, A., & Setoyama, H. (1995) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1995.tb02242.x · Cited by 346

Unseen Forces: The Influence of Bacteria on Animal Development

McFall‐Ngai, M. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0522 · Cited by 299

[Crohn's disease].

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Examining the Role of Paneth Cells in the Small Intestine by Lineage Ablation in Transgenic Mice

Garabedian, E. M., Roberts, L. J., McNevin, M. S., & Gordon, J. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23729 · Cited by 279

Differential Roles of Segmented Filamentous Bacteria and Clostridia in Development of the Intestinal Immune System

Umesaki, Y., Setoyama, H., Matsumoto, S., Imaoka, A., & Itoh, K. (1999) · Infection and Immunity · doi:10.1128/iai.67.7.3504-3511.1999 · Cited by 271

Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus.

Umesaki, Y., Setoyama, H., Matsumoto, S., & Okada, Y. (1993) · PubMed Central · Cited by 270

The hygiene hypotheslis revised: is the rising frequency of allergy due to changes in the intestinal flora?

Wold, A. E. (1998) · Allergy · doi:10.1111/j.1398-9995.1998.tb04953.x · Cited by 263

Glycans as legislators of host-microbial interactions: spanning the spectrum from symbiosis to pathogenicity

Hooper, L. V., & Gordon, J. I. (2001) · Glycobiology · doi:10.1093/glycob/11.2.1r · Cited by 263

In Vivo Modulation of Cytolytic Activity and Thy-1 Expression In TCR-γδ + Intraepithelial Lymphocytes

Lefrançois, L., & Goodman, T. G. (1989) · Science · doi:10.1126/science.2564701 · Cited by 256

Dietary intake, energy metabolism, and excretory losses of adult male germfree Wistar rats.

Wöstmann, B. S. J., Larkin, C. J., Moriarty, A., & Bruckner-Kardoss, E. (1983) · PubMed · Cited by 228

Gastrointestinal Microflora in Mammalian Nutrition

Savage, D. C. (1986) · Annual Review of Nutrition · doi:10.1146/annurev.nu.06.070186.001103 · Cited by 197

An important regulatory role for CD4 + CD8αα T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease

Das, G., Augustine, M. M., Das, J., Bottomly, K., Ray, P., & Ray, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831037100 · Cited by 197

THE GERMFREE ANIMAL IN NUTRITIONAL STUDIES

Wostmann, B. S. (1981) · Annual Review of Nutrition · doi:10.1146/annurev.nu.01.070181.001353 · Cited by 188

Bacterial symbionts induce host organ morphogenesis during early postembryonic development of the squid Euprymna scolopes

Montgomery, M. K., & McFall‐Ngai, M. (1994) · Development · doi:10.1242/dev.120.7.1719 · Cited by 175

Germ-free and Colonized Mice Generate the Same Products from Enteric Prodefensins

Pütsep, K., Axelsson, L.-G., Boman, A., Midtvedt, T., Normark, S. J., Boman, H. G., & Andersson, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007816200 · Cited by 140

Vibrio fischeri lipopolysaccharide induces developmental apoptosis, but not complete morphogenesis, of the Euprymna scolopes symbiotic light organ.

Foster, J. S., Apicella, M., & McFall-Ngai, M. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9868 · Cited by 140

Transit time of epithelial cells in the small intestines of germfree mice and ex-germfree mice associated with indigenous microorganisms

Savage, D. C., Siegel, J. E., Snellen, J. E., & Whitt, D. D. (1981) · Applied and Environmental Microbiology · doi:10.1128/aem.42.6.996-1001.1981 · Cited by 118

Induction of a Gradual, Reversible Morphogenesis of Its Host’s Epithelial Brush Border by Vibrio fischeri

Lamarcq, L. H., & McFall‐Ngai, M. (1998) · Infection and Immunity · doi:10.1128/iai.66.2.777-785.1998 · Cited by 79

Induction of apoptosis by cooperative bacteria in the morphogenesis of host epithelial tissues

Foster, J. S., & McFall‐Ngai, M. (1998) · Development Genes and Evolution · doi:10.1007/s004270050185 · Cited by 77

The Neonatal Development of Intraepithelial and LaminaPropria Lymphocytes in the Murine Small Intestine

ter Steege, J. C. A., Buurman, W. A., & Forget, P. (1996) · Journal of Immunology Research · doi:10.1155/1997/34891 · Cited by 66

II. The yin and yang of T cells in intestinal inflammation: pathogenic and protective roles in a mouse colitis model

Winter, H. A. M. D., Cheroutre, H., & Kronenberg, M. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.6.g1317 · Cited by 61

Role of passive and adaptive immunity in influencing enterocyte-specific gene expression

Jenkins, S., Wang, J., MUKTA, V., Vela, J. L., Sahagun, O., Gabbay, P., Hoang, L., Diaz, R. L., Aranda, R., & Martı́n, M. G. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00130.2003 · Cited by 49

It's the ecology, stupid!

Dusheck, J. (2002) · Nature · doi:10.1038/418578a · Cited by 32

Nutritional and developmental regulation of glycosylation processes indigestive organs

Biol, M.-C., Martin, A., & Louisot, P. (1992) · Biochimie · doi:10.1016/0300-9084(92)90180-m · Cited by 28

The Neonatal Gastrointestinal Tract

Neu, J., & Li, N. (2003) · NeoReviews · doi:10.1542/neo.4-1-e7 · Cited by 27

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029

An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System

Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910

The gut microbiota influences blood-brain barrier permeability in mice

Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530

The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing

Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361

The NIH Human Microbiome ProjectPreprint

The NIH HMP Working Group, Peterson, J. L., Garges, S., Giovanni, M. Y., McInnes, P., Wang, L., Schloss, J. A., Bonazzi, V. R., McEwen, J. E., Wetterstrand, K. A., et al. (2009) · Genome Research · doi:10.1101/gr.096651.109 · Cited by 2,168

Host-microbial interaction in the mammalian intestine and their metabolic role inside

Dipendra Raj, P., eya, Souza, R. D., Rahman, M. M., Akhter, S., Kim, H.-J., & Hong, S.-T. (2012) · Biomedical Research-tokyo · Cited by 13

Bacteria and early human development

Wilks, M. (2007) · Early Human Development · doi:10.1016/j.earlhumdev.2007.01.007 · Cited by 40

Commensal bacteria and epithelial cross talk in the developing intestine

Rautava, S., & Walker, W. A. (2007) · Current Gastroenterology Reports · doi:10.1007/s11894-007-0047-7 · Cited by 56

Why bacteria matter in animal development and evolution

Fraune, S., & Bosch, T. C. G. (2010) · BioEssays · doi:10.1002/bies.200900192 · Cited by 321

Microbes and the Developing Gastrointestinal Tract

Neu, J., Douglas‐Escobar, M., & Lopez, M. (2007) · Nutrition in Clinical Practice · doi:10.1177/0115426507022002174 · Cited by 82