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Cited by 485

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa

Open access
Ramos, Hugo Cruz, Rumbo, Martin, Sirard, Jean-Claude·2004·Trends in Microbiology
DOI 10.1016/j.tim.2004.09.002
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Abstract

Flagella contribute to the virulence of pathogenic bacteria through chemotaxis, adhesion to and invasion of host surfaces. Flagellin is the structural protein that forms the major portion of flagellar filaments. Thus, flagellin consists of a conserved domain that is widespread in bacterial species and is dedicated to filament polymerization. Conversely, mammalian hosts detect the conserved domain on flagellin monomers through Toll-like receptor (TLR) 5, which triggers proinflammatory and adaptive immune responses. This review describes the relationships among flagellin molecular structure, bacterial virulence and host defenses, with special emphasis on mucosal tissues.

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Crossref · 10.1016/j.tim.2004.09.002

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Metadata

Authors
Ramos, H. C., Rumbo, M., & Sirard, J.-C.
Venue
Trends in Microbiology
Publisher
Elsevier BV
Published
2004-11
Volume
12
Issue
11
Pages
509-517
ISSN
0966-842X (ISSN-L)
DOI
10.1016/j.tim.2004.09.002
OpenAlex
W2137003603
Cited by
485
References
56
FWCI
1.29
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa. https://app.cochat.ai/papers/10.1016/j.tim.2004.09.002
The paper
Ramos, H. C., Rumbo, M., & Sirard, J.-C. (2004). Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa. Trends in Microbiology. https://doi.org/10.1016/j.tim.2004.09.002

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.