The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection
Open accessAbstract
Human cytomegalovirus (HCMV) infection causes dramatic alterations of intermediary metabolism, similar to those found in tumor cells. In infected cells, glucose carbon is not completely broken down by the tricarboxylic acid (TCA) cycle for energy; instead it is used biosynthetically. This process requires increased glucose uptake, increased glycolysis and the diversion of glucose carbon, in the form of citrate, from the TCA cycle for use in HCMV-induced fatty acid biosynthesis. The diversion of citrate from the TCA cycle (cataplerosis) requires induction of enzymes to promote glutaminolysis, the conversion of glutamine to -ketoglutarate in order to maintain the TCA cycle (anaplerosis) and ATP production. Such changes could result in heretofore uncharacterized pathogenesis, potentially implicating HCMV as a subtle co-factor in many maladies, including oncogenesis. Recognition of the effects of HCMV, and other viruses, on host cell metabolism will provide new understanding of viral pathogenesis and novel avenues for antiviral therapy.
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Cites
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Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
ATP-citrate lyase links cellular metabolism to histone acetylation
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Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
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�ber den Stoffwechsel der Carcinomzelle
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Motta, F., Barone, E., Sica, A., & Selmi, C. (2022) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-022-08941-1 · Cited by 411
Multifaceted roles for lipids in viral infection
Heaton, N. S., & Randall, G. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.03.007 · Cited by 381
Targeting metabolic reprogramming by influenza infection for therapeutic intervention
Smallwood, H. S., Duan, S., Morfouace, M., Rezinciuc, S., Shulkin, B. L., Shelat, A., Zink, E. E., Milasta, S., Bajracharya, R., Oluwaseum, A. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.039 · Cited by 171
Metadata
- Authors
- Yu, Y., Clippinger, A. J., & Alwine, J. C.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 19
- Issue
- 7
- Pages
- 360-367
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2002640020
- Cited by
- 197
- References
- 9
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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