The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Collateral sensitivity of antibiotic-resistant microbes
Open accessAbstract
Understanding how evolution of microbial resistance towards a given antibiotic influences susceptibility to other drugs is a challenge of profound importance. By combining laboratory evolution, genome sequencing, and functional analyses, recent works have charted the map of evolutionary trade-offs between antibiotics and have explored the underlying molecular mechanisms. Strikingly, mutations that caused multidrug resistance in bacteria simultaneously enhanced sensitivity to many other unrelated drugs (collateral sensitivity). Here, we explore how this emerging research sheds new light on resistance mechanisms and the way it could be exploited for the development of alternative antimicrobial strategies.
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Cites
The Competitive Cost of Antibiotic Resistance in Mycobacterium tuberculosis
Gagneux, S., Long, C. D., Small, P. M., Van, T., Schoolnik, G. K., & Bohannan, B. J. M. (2006) · Science · doi:10.1126/science.1124410 · Cited by 627
Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B
Vincent, B. M., Lancaster, A. K., Scherz-Shouval, R., Whitesell, L., & Lindquist, S. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001692 · Cited by 322 · cited 2×
“As a consequence, strains carrying these mutations were hypersensitive to oxidative stress, temperature, and killing by neutrophils, and they also had defects in filamentation and tissue invasion [29].”
BackgroundPhysiology and Antibiotic Susceptibility of Staphylococcus aureus Small Colony Variants
Baumert, N., von Eiff, C., Schaaff, F., Peters, G., Proctor, R. A., & Sahl, H.-G. (2002) · Microbial Drug Resistance · doi:10.1089/10766290260469507 · Cited by 130
Cited by
Emerging contaminants: A One Health perspective
Wang, F., Xiang, L., Sze-Yin Leung, K., Elsner, M., Zhang, Y., Guo, Y., Pan, B., Sun, H., An, T., Ying, G., et al. (2024) · The Innovation · doi:10.1016/j.xinn.2024.100612 · Cited by 639
The rapid spread of carbapenem-resistant Enterobacteriaceae
Potter, R. F., D’Souza, A. W., & Dantas, G. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.09.002 · Cited by 403
Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides
Lázár, V., Martins, A., Spohn, R., Daruka, L., Grézal, G., Fekete, G., Számel, M., Jangir, P. K., Kintses, B., Csörgő, B., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0164-0 · Cited by 375
Self-citationAntibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?
Domalaon, R., Idowu, T., Zhanel, G. G., & Schweizer, F. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00077-17 · Cited by 285
Dhawan, A., Nichol, D., Kinose, F., Abazeed, M. E., Marusyk, A., Haura, E. B., & Scott, J. G. (2017) · Scientific Reports · doi:10.1038/s41598-017-00791-8 · Cited by 79
Metadata
- Authors
- Pál, C., Papp, B., & Lázár, V.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 23
- Issue
- 7
- Pages
- 401-407
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2164782185
- Cited by
- 270
- References
- 3
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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