The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Bowel Biofilms: Tipping Points between a Healthy and Compromised Gut?
Open accessAbstract
Bacterial communities are known to impact human health and disease. Mixed species biofilms, mostly pathogenic in nature, have been observed in dental and gastric infections as well as in intestinal diseases, chronic gut wounds and colon cancer. Apart from the appendix, the presence of thick polymicrobial biofilms in the healthy gut mucosa is still debated. Polymicrobial biofilms containing potential pathogens appear to be an early-warning signal of developing disease and can be regarded as a tipping point between a healthy and a diseased state of the gut mucosa. Key biofilm-forming pathogens and associated molecules hold promise as biomarkers. Criteria to distinguish microcolonies from biofilms are crucial to provide clarity when reporting biofilm-related phenomena in health and disease in the gut.
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Cites
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Flagged first, then by citations
Research works printed but not linked: 1
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Fassarella, M., Blaak, E. E., Penders, J., Nauta, A., Smidt, H., & Zoetendal, E. G. (2020) · Gut · doi:10.1136/gutjnl-2020-321747 · Cited by 818
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Metadata
- Authors
- Tytgat, H. L. P., Nobrega, F. L., van der Oost, J., & de Vos, W. M.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Tytgat, Hanne L.P.
- ORCID
- Tytgat, Hanne L.P.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 27
- Issue
- 1
- Pages
- 17-25
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2890494833
- Cited by
- 144
- References
- 62
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 22 · 2023: 27 · 2022: 19 · 2021: 24 · 2020: 15 · 2019: 10
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Repository for Publications and Research Data (ETH Zurich) (acceptedVersion, cc-by-nc-nd)
- ePrints Soton (University of Southampton) (submittedVersion)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- ETH Zürich Research Collection
- Funders
- ERC grant Microbes Inside (250172)
- Soehngen Institute of Anaerobic Microbiology (024.002.002)
- The Netherlands Organization for Scientific Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Keywords
- polymicrobial biofilms, gut microbiota, intestinal mucosa, biomarkers, microcolonies, intestinal diseases, colon cancer
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Bacterial Infections, Colon, Humans, Biomarkers, Biofilms, Microbiota
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