Cited by 153Bacterial biofilms and quorum sensingGut microbiota and healthEscherichia coli research studies

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Bowel Biofilms: Tipping Points between a Healthy and Compromised Gut?

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Tytgat, Hanne L.P., Nobrega, Franklin L., van der Oost, John, de Vos, Willem M.·2019·Trends in Microbiology

DOI 10.1016/j.tim.2018.08.009

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Abstract

Bacterial communities are known to impact human health and disease. Mixed species biofilms, mostly pathogenic in nature, have been observed in dental and gastric infections as well as in intestinal diseases, chronic gut wounds and colon cancer. Apart from the appendix, the presence of thick polymicrobial biofilms in the healthy gut mucosa is still debated. Polymicrobial biofilms containing potential pathogens appear to be an early-warning signal of developing disease and can be regarded as a tipping point between a healthy and a diseased state of the gut mucosa. Key biofilm-forming pathogens and associated molecules hold promise as biomarkers. Criteria to distinguish microcolonies from biofilms are crucial to provide clarity when reporting biofilm-related phenomena in health and disease in the gut.

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Authors: Tytgat, H. L. P., Nobrega, F. L., van der Oost, J., & de Vos, W. M.
Affiliations: ETH Zurich (CH)
Corresponding author: Tytgat, Hanne L.P.
ORCID: Tytgat, Hanne L.P.
Venue: Trends in Microbiology
Publisher: Elsevier BV
Published: 2019-01
Volume: 27
Issue: 1
Pages: 17-25
ISSN: 0966-842X (ISSN-L)
DOI: 10.1016/j.tim.2018.08.009
OpenAlex: W2890494833
Cited by: 144
References: 62
Citations by year: 2026: 6 · 2025: 20 · 2024: 22 · 2023: 27 · 2022: 19 · 2021: 24 · 2020: 15 · 2019: 10
FWCI: 1.23
Type: journal article
Language: en
Open access: green
research.wur.nl
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Microbiology (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Repository for Publications and Research Data (ETH Zurich) (acceptedVersion, cc-by-nc-nd)
ePrints Soton (University of Southampton) (submittedVersion)
Työväentutkimus Vuosikirja (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
ETH Zürich Research Collection
Funders: ERC grant Microbes Inside (250172)
Soehngen Institute of Anaerobic Microbiology (024.002.002)
The Netherlands Organization for Scientific Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Keywords: polymicrobial biofilms, gut microbiota, intestinal mucosa, biomarkers, microcolonies, intestinal diseases, colon cancer
MeSH terms: Gastrointestinal Microbiome, Bacteria, Bacterial Infections, Colon, Humans, Biomarkers, Biofilms, Microbiota

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Bowel Biofilms: Tipping Points between a Healthy and Compromised Gut?

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