The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Engineering Bacteriophages as Versatile Biologics
Abstract
Viruses of bacteria (bacteriophages or phages) are highly evolved nanomachines that recognize bacterial cell walls, deliver genetic information, and kill or transform their targets with unparalleled specificity. For a long time, the use of genetically modified phages was limited to phage display approaches and fundamental research. This is mostly because phage engineering has been a complex and time-consuming task, applicable for only a few well characterized model phages. Recent advances in sequencing technology and molecular biology gave rise to rapid and precise tools that enable modification of less-well-characterized phages. These methods will pave the way for the development of modular designer-phages as versatile biologics that efficiently control multidrug-resistant bacteria and provide novel tools for pathogen detection, drug development, and beyond.
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Cites
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871
Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases
Citorik, R. J., Mimee, M., & Lu, T. K. (2014) · Nature Biotechnology · doi:10.1038/nbt.3011 · Cited by 808
L-form bacteria, cell walls and the origins of life
Errington, J. (2013) · Open Biology · doi:10.1098/rsob.120143 · Cited by 198 · cited 1×
“L-forms are cell-wall-deficient bacteria that divide and grow in osmotically stabilized media [92,93].”
Background
Cited by
Phage therapy: From biological mechanisms to future directions
Strathdee, S. A., Hatfull, G. F., Mutalik, V. K., & Schooley, R. T. (2023) · Cell · doi:10.1016/j.cell.2022.11.017 · Cited by 817
Diversity and Function of Phage Encoded Depolymerases
Knecht, L. E., Veljkovic, M., & Fieseler, L. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02949 · Cited by 359
Dong, X., Pan, P., Zheng, D.-W., Bao, P., Zeng, X., & Zhang, X.-Z. (2020) · Science Advances · doi:10.1126/sciadv.aba1590 · Cited by 282
Enhancing phage therapy through synthetic biology and genome engineering
Lenneman, B. R., Fernbach, J., Loessner, M. J., Lu, T. K., & Kilcher, S. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.11.003 · Cited by 208
Self-citationHigh-throughput mapping of the phage resistance landscape in E. coli
Mutalik, V. K., Adler, B. A., Rishi, H. S., Piya, D., Zhong, C., Koskella, B., Kutter, E. M., Calendar, R., Novichkov, P. S., Price, M. N., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000877 · Cited by 171
Metadata
- Authors
- Kilcher, S., & Loessner, M. J.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 27
- Issue
- 4
- Pages
- 355-367
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2897780900
- Cited by
- 171
- References
- 3
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
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