Fatty acids as antibiofilm and antivirulence agents.
Abstract
Fatty acids (FAs) have emerged as a potential alternative to conventional antibiotics. Since many microbes respond differently to a variety of natural and synthetic FAs, substantial efforts have been made to understand the unique features of FAs that function as antimicrobials at high doses and biofilm inhibitors at low doses. Here, we provide an overview of the emerging antibiofilm properties of FAs and their relations to virulence and quorum sensing, such as diffusible signal factors (DSFs), acyl-homoserine lactones, and autoinducer-2 systems. Several FAs mimic DSFs and control motility, fimbriae, hyphae, and biofilm development as well as virulence characteristics of diverse microbes. The findings of FAs as antibiofilm and antivirulence agents will provide a new paradigm to cope with recalcitrant pathogens.
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Combination of fatty acids with antimicrobials could reduce multidrug-resistant bacteria.
“As natural molecules, fatty acids have great potential and their combination with antimicrobials could reduce multidrug-resistant bacteria (Kumar et al., 2020).”
From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Kumar et al., 2020
Lauric acid inhibits the swarming motility of Proteus mirabilis in a dose-dependent manner and, at higher levels, acts on Clostridium difficile cell membranes and adhesins.
“Kumar et al. (2020) showed that LA inhibits the swarming motility of P. mirabilis in a dose-dependent manner and, at higher levels, acts on Clostridium difficile cell membranes and adhesins.”
From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Kumar et al. (2020)
Lauric acid can inhibit hemolysin expression, extracellular polysaccharide production, and biofilm production through an RsbA-dependent pathway.
“LA can inhibit hemolysin expression, extracellular polysaccharides (EPS) and biofilm production through RsbA (a histidine-containing phosphotransmitter of two-component signaling system) dependent pathway.”
From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Kumar et al., 2020
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References 93 · Cited by 216
- Authors
- Kumar, P., Lee, J.-H., Beyenal, H., & Lee, J.
- Affiliations
- Yeungnam University (KR)
- Washington State University (US)
- Corresponding author
- Lee, Jintae
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 28
- Issue
- 9
- Pages
- 753-768
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W3021703722
- Cited by
- 216
- References
- 93
- Citations by year
- 2026: 22 · 2025: 27 · 2024: 36 · 2023: 44 · 2022: 43 · 2021: 36 · 2020: 8
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea
- Ministry of Education (2014R1A6A1031189)
- Ministry of Agriculture, Food and Rural Affairs (119034-3)
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- fatty acids, antibiofilm agents, anti-virulence agents, biofilm inhibition, quorum sensing, diffusible signal factor, N-acyl homoserine lactones, autoinducer-2, bacterial virulence, bacterial motility, fimbriae, fungal hyphae, antibiotic alternatives
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Bacterial Infections, Fatty Acids, Humans, Virulence, Biofilms, Drug Resistance, Bacterial, Quorum Sensing
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