Phages to the rescue: in situ editing of the gut microbiota
Open accessAbstract
The gut microbiome contains numerous bacteria tied to our health. However, genetically modifying this community remains a major challenge. Brödel et al. take a critical step by engineering bacteriophages to efficiently deliver gene editors without propagation of the genetic cargo, efficiently introducing edits to bacteria residing in the mouse gut.
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Recent research in other non-PD conditions has highlighted the potential transferability of targeted approaches like engineered symbiotic bacteria, CRISPR-Cas9 technologies, and bacteriophages for targeting specific bacterial populations.
“Recent research in other non-PD conditions has highlighted the potential transferability of targeted approaches like engineered symbiotic bacteria, CRISPR-Cas9 technologies, and bacteriophages for targeting specific bacterial populations [171–173].”
From The gut–brain axis in early Parkinson’s disease: from prodrome to prevention (2025) · cites this paper as [172]
Cites
Krink, N., Nikel, P. I., & Beisel, C. L. (2024) · EMBO Reports · doi:10.1038/s44319-024-00086-w · Cited by 19 · see citing works
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The gut–brain axis in early Parkinson’s disease: from prodrome to prevention
Oliver, P. J., Civitelli, L., & Hu, M. T. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13138-5 · Cited by 42 · see citing works
- Authors
- Kamm, C., & Beisel, C. L.
- Affiliations
- Helmholtz Centre for Infection Research (DE)
- University of Würzburg (DE)
- Corresponding author
- Beisel, Chase L.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2024-10
- Volume
- 32
- Issue
- 10
- Pages
- 934-935
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W4402504758
- Cited by
- 6
- References
- 1
- Citations by year
- 2026: 4 · 2025: 2
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Microbiology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- European Research Council (865973)
- German Research Foundation (BE 6703/1-2, BE 6703/2-1, BE 6703/3-1)
- Topics
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- bacteriophages, CRISPR gene editing, gut microbiota, mouse gut microbiome, microbiome engineering, phage display
- MeSH terms
- Gastrointestinal Microbiome, Gene Editing, Animals, Bacteria, Bacteriophages, Humans, Mice
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